Effects of Suppository Acetaminophen, Bupivacaine Wound Infiltration, and Caudal Block With Bupivacaine on Postoperative Pain in Pediatric Inguinal Herniorrhaphy

Jahromi, S A Hosseini; poor, Sadegh Sadeghi; Valami, S M Hosseini; Javadi, Amir

doi:10.5812/aapm.3551

Cited by 23 publications

(16 citation statements)

References 13 publications

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“…Both interventions were performed after surgery in two studies [13, 14, 17]; however the other 4 studies performed caudal preoperatively and infiltration postoperatively [14–16, 18]. Except for Lafferty and colleagues (only orchidopexy) [14], all included hernia surgeries only.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Caudal Block as Compared to Noncaudal Regional Techniques for Inguinal Surgeries in Children

Shanthanna

Singh

Guyatt

2014

BioMed Research International

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This systematic review and meta-analysis were designed to compare the analgesic effectiveness and adverse effects with the use of caudal analgesia as compared to noncaudal regional analgesia techniques in children undergoing inguinal surgeries. MEDLINE, EMBASE, and CENTRAL (Cochrane) databases were searched for randomized control trials published in English language from 1946 up to 2013. Use of rescue analgesia and adverse effects were considered as primary and secondary outcomes, respectively. Outcomes were pooled using random effects model and reported as risk ratio (RR) with 95% CI. Out of 3240 hits and 24 reports for final selection, 17 were included in this review. Caudal analgesia was found to be better in both early (RR = 0.81 [0.66, 0.99], P = 0.04) and late (RR = 0.81 [0.69, 0.96], P = 0.01) periods, but with a significant risk of motor block and urinary retention. According to GRADE, the quality of evidence was moderate. Although potentially superior, caudal analgesia increases the chance of motor block and urinary retention. There are limited studies to demonstrate that the technical superiority using ultrasound translates into better clinical success with the inguinal nerve blocks.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Caudal Block as Compared to Noncaudal Regional Techniques for Inguinal Surgeries in Children

Shanthanna

Singh

Guyatt

2014

BioMed Research International

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“…Also another study by Hosseini Jahromi et al (25) evaluated the effects of suppository Acetaminophen, Bupivacaine Wound Infiltration, and Caudal Block with Bupivacaine on postoperative pain in management of inguinal herniorrhaphy in children, and it was seen that bupivacaine infiltration and caudal block with bupivacaine provide better analgesia than suppository acetaminophen. However in our study also the combination treatment resulted in a better analgesic response.…”

Section: Discussionmentioning

confidence: 99%

Analgesic Efficacy of Diclofenac and Paracetamol vs. Meperidine in Cesarean Section

et al. 2013

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Background:One of the most important complications in cesarean surgery is postoperative pain, and different ways have been proposed to control it.Objectives:The purpose of this study was to determine the efficacy of Diclofenac and Paracetamol combination in comparison with Meperidine on postoperative pain after cesarean surgery.Patients and Methods:One hundred and twenty women candidates for elective cesarean section under spinal anesthesia categorized as ASA class I were selected and randomly assigned to receive either Diclofenac suppository at the end of the operation and thereafter 1 gram infused bolus of Paracetamol (group A), or 20 mg bolus of Meperidine after transition to recovery room (group B) to control postoperative pain.Results:Postoperative pain was present in recovery in 38.3% and 23.3% in groups B and A, respectively (P = 0.009). Postoperative pain was seen after six hours of operation in 38.7% and 16.7% in groups B and A, respectively (P = 0.010). Postoperative pain was present after 12 hours of operation in 38.3% and 15% in groups B and A, respectively (P = 0.002). The additive Meperidine use was the same between the two groups in recovery (P > 0.05). The additive Meperidine use was seen after six hours of operation in 26.7% and 6.7% in groups B and A, respectively (P = 0.013). The additive Meperidine use was seen after 12 hours of operation in 16.7% and none of the patients in groups B and A, respectively (P = 0.004). The frequency of drug adverse effects was the same between the two groups (P > 0.05).Conclusions:Totally, according to the obtained results it may be concluded that Paracetamol and Diclofenac combination would have a better efficacy in postoperative pain control and need reduction to additive analgesia compared to Meperidine.

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“…It has always been a serious challenge in medicine, as it has an important protective role in avoiding, or treating, genuine or potential tissue damage ( 1 , 2 ). Although numerous agents, such as non-steroidal anti-inflammatory or opioid drugs are primarily used to control pain ( 3 - 6 ), these sometimes have many adverse effects and cause gastrointestinal and renal disorders. Therefore, most people would prefer new drugs that have fewer side effects and which are cheaper and easily available ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain in Male Rats

2016

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Background:The drive toward the use of medicinal plants has been increasing in recent years. They have few side effects and a large variety of efficient components.Objectives:This study was designed to investigate the analgesic effects of hydroalcoholic Rhus coriaria leaf extract (HRCLE) in a rat model.Materials and Methods:A total of 42 adult male rats were divided into seven groups: a control group (the animals did not receive any drug), three HRCLE groups, (receiving 80, 100, and 300 mg/kg, intraperitoneally [ip]), a morphine group (1 mg/kg, ip) an aspirin group (1 mg/kg, ip), and a group that received 300 mg/kg of HRCLE plus naloxone (1 mg/kg, ip). The analgesic effects of HRCLE were assessed via writhing, tail flick, and formalin tests, and the data obtained were compared with the control group using one-way analysis of variance and Tukey post hoc tests.Results:HRCLE signiﬁcantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at the 100 mg/kg dose (in the chronic phase) and at the 300 mg/kg dose (in the chronic-acute phase) in the formalin test. Interestingly, the greatest effect was observed at the 300 mg/kg HRCLE dose in the tail flick test. Simultaneous utilization of naloxone and HRCLE inhibited the anti-nociceptive effect of the extract in all tests. It is worth mentioning that aspirin and morphine revealed anti-nociceptive effects in all tests.Conclusions:Our findings suggest that the analgesic effect of HRCLE may be mediated via both peripheral and central mechanisms. The presence of flavonoids might be responsible for the anti-nociceptive activity of this plant.

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Effects of Suppository Acetaminophen, Bupivacaine Wound Infiltration, and Caudal Block With Bupivacaine on Postoperative Pain in Pediatric Inguinal Herniorrhaphy

Cited by 23 publications

References 13 publications

A Systematic Review and Meta-Analysis of Caudal Block as Compared to Noncaudal Regional Techniques for Inguinal Surgeries in Children

A Systematic Review and Meta-Analysis of Caudal Block as Compared to Noncaudal Regional Techniques for Inguinal Surgeries in Children

Analgesic Efficacy of Diclofenac and Paracetamol vs. Meperidine in Cesarean Section

Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain in Male Rats

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