Effects of Supplementation of<i>Bacillus subtilis</i>LS 1–2 Grown on Citrus-juice Waste and Corn-Soybean Meal Substrate on Performance and Gut Health of Weaning Pigs

Lee, S.H.; Ingale, S.L.; Kim, J.S.; Kim, K.H.; Lokhande, Anushka; Kwon, I.K.; Kim, Y.H.; Chae, B. J.

doi:10.5958/0974-181x.2014.01332.8

Cited by 2 publications

(3 citation statements)

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“…Results revealed in the current study indicate that supplementation of Bacillus subtilis improved growth rate, reduced gut permeability, and may modify intestinal health of weaned pigs experimentally challenged with F18 E. coli. These findings are in agreement with previous published research, showing an improvement of growth performance and health status in piglets fed different strains of Bacillus subtilis [27][28][29]. The potential mechanisms related to those benefits may include but are not limited to: 1) supplementation of Bacillus subtilis (DSM 25841) improved gut integrity by enhancing gut barrier function and reducing gut permeability in the jejunum; 2) supplementation of Bacillus subtilis regulated intestinal immunity of weaned pigs; 3) inclusion of Bacillus subtilis modulated the gut microbiome and their metabolites.…”

Section: Discussionsupporting

confidence: 94%

“…Other potential mechanisms may also be related to the enhanced growth rate by feeding Bacillus subtilis. As an example, Bacillus-based DFM may enhance growth performance of weaned pigs by improving digestibility of energy and nutrients [29,54]. In particular, Bacillus-based DFM may increase fiber degradation in the intestinal tract of pigs [11,55].…”

Section: Discussionmentioning

confidence: 99%

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Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli

Kim

Xiong

et al. 2019

J Animal Sci Biotechnol

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Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials (DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis (DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli (E. coli). Results: The F18 E. coli infection reduced (P < 0.05) growth performance and intestinal villi height, whereas increased (P < 0.05) diarrhea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation (PI) (P < 0.05) and d 0 to 11 PI (P = 0.058). Supplementation of high dose of Bacillus subtilis reduced (P < 0.05) both transcellular and paracellular permeability on d 5 and d 11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated (P < 0.05) the mRNA expression of SLC5A10 (soluble carrier family 5 member 10) and MUC2 (mucin 2) on d 5 PI, but down-regulated (P < 0.05) expression of SLC5A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated (P < 0.05) the mRNA expression of CFTR and ZO1 on d 5 PI and SLC5A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased (P < 0.05) the mRNA expression of several immune genes (IL1A, IL1B, and IL7 on d 5 PI, and IL1B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1A on d 5 PI (P = 0.07) and IL6 on d 11 PI (P < 0.05) in ileal mucosa of E. coli infected pigs. Conclusions: Supplementation of Bacillus subtilis (DSM 25841) enhanced growth rate and improved gut barrier function of weaned pigs experimentally infected with a pathogenic E. coli.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli

Kim

Xiong

et al. 2019

J Animal Sci Biotechnol

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“…The growth performance of DFM piglets is better than those of CON, ABO and ENZ piglets, which may be due to better nutrient digestion and absorption. In agreement with our results, Lee et al [44] reported linear effects of B. subtilis on VH and VCR, which are generally associated with better nutrient utilization. However, some authors found that villi integrity was not affected by DFM compared to CON.…”

Section: Discussionsupporting

confidence: 93%

Effect of a Multi-Species Direct-Fed Microbial on Growth Performance, Nutrient Digestibility, Intestinal Morphology and Colonic Volatile Fatty Acids in Weanling Pigs

Kongpanna,

Doerr,

Nilubol

et al. 2024

Animals

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The potentials of ABO replacer of ENZ and DFM on growth performance, AID, colonic VFAs, gut morphology, fecal score and diarrhea incidence were evaluated. We randomly assigned 120 piglets to four experimental diets that included: (1) control diet (CON), fed the basal ration; (2) ABO was added at 250 ppm of in-feed ABO; (3) ENZ was added at a rate of 3 kg/ton feed; (4) DFM was added with 50 × 106 cfu/g of Bacillus subtilis and 2 × 106 cfu/g of Lactobacillus spp. at a rate of 1.2 kg/ton feed. A complete randomized design used six pens per treatment with five pigs per pen. Pigs had ad libitum access to feed and water throughout the 6-week trial. Feed intake and BW were recorded on weeks 0, 2, 4 and 6, as well as fecal scores and diarrhea incidences (visually recorded and calculated). At weeks 2 and 4, a sub-sample of pigs (n = 6) was sacrificed for intestinal morphology, enzyme activity and VFAs. The results of the study demonstrated that DFM piglets showed increased final BW (3 kg) (p < 0.001) vs. CON. Likewise, ADG was positively affected by the incorporation of ABO, ENZ and DFM in the diets, with an average increase of 8 to 17% on ADG compared with CON (p < 0.001). The AID of gross energy, organic matter, CP and EAAs in piglets fed ENZ and DFM were significantly higher (p < 0.05) than those of CON and ABO at weeks 2 and 4. Inclusion of DFM increased intestinal morphology, enzymatic activities and propionic and butyric acid more than in pigs fed CON, ABO and ENZ (p < 0.05). The fecal score and diarrhea incidence generally decreased over time in pigs fed DFM (p < 0.05). These findings indicate that dietary supplementation with DFM has better effects at any period on growth performance, CP and AA digestibility and beneficially altered the intestinal health in weanling piglets.

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Effects of Supplementation ofBacillus subtilisLS 1–2 Grown on Citrus-juice Waste and Corn-Soybean Meal Substrate on Performance and Gut Health of Weaning Pigs

Cited by 2 publications

References 0 publications

Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli

Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli

Effect of a Multi-Species Direct-Fed Microbial on Growth Performance, Nutrient Digestibility, Intestinal Morphology and Colonic Volatile Fatty Acids in Weanling Pigs

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