Effects of Supplementary Seleno-L-methionine on Atopic Dermatitis-Like Skin Lesions in Mice

Arakawa, Takeshi; Sugiyama, Takahiro; Matsuura, Haruka; Okuno, Tomofumi; Ogino, Hirofumi; Sakazaki, Fumitoshi; Ueno, Hitoshi

doi:10.1248/bpb.b18-00349

Cited by 8 publications

(7 citation statements)

References 43 publications

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“…However, this remains speculative as we did not measure B-cell activation markers. In a murine model for atopic dermatitis, oral administration of Se suppressed the development of atopic dermatitis-like skin lesions, lowered total IgE levels, reduced skin expression of IL-4 and led to a lower number of mast cells in the skin [ 36 ]. In our current study, we observed a significantly lower expression of serum mMCP-1 in mice that were fed the high Se diet, suggesting that mast cells may be affected also by this dietary intervention with Se.…”

Section: Discussionmentioning

confidence: 99%

Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy

et al. 2021

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Cow’s milk allergy is a common food allergy in infants, and is associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one of the essential micronutrients for humans and animals, is an important bioelement which can influence both innate and adaptive immune responses. However, the effects of Se on food allergy are still largely unknown. In the current study it was investigated whether dietary Se supplementation can inhibit whey-induced food allergy in an animal research model. Three-week-old female C3H/HeOuJ mice were intragastrically sensitized with whey protein and cholera toxin and randomly assigned to receive a control, low, medium or high Se diet. Acute allergic symptoms, allergen specific immunoglobulin (Ig) E levels and mast cell degranulation were determined upon whey challenge. Body temperature was significantly higher in mice that received the medium Se diet 60 min after the oral challenge with whey compared to the positive control group, which is indicative of impaired anaphylaxis. This was accompanied by reductions in antigen-specific immunoglobulins and reduced levels of mouse mast cell protease-1 (mMCP-1). This study demonstrates that oral Se supplementation may modulate allergic responses to whey by decreasing specific antibody responses and mMCP-1 release.

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Section: Discussionmentioning

confidence: 99%

Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy

et al. 2021

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“…Regarding the latter suggested urushiol-mediated immunogenic mechanisms, isolated CD8+ T cells from skin lesions of urushiol sensitized human subjects favor their role in the effector phase of contact dermatitis produced by poison ivy (Kalish and Johnson, 1990). Current studies indicate that IL-4 is an important downregulator during the elicitation phase of contact sensitivity (CS), demonstrated by the presence of high levels of IL-4 mRNA in the dermis and epidermis following skin challenge with trinitrochlorobenzene (TNCB) (Asada et al, 1997; Arakawa et al, 2018). Also, mice treated with anti-IL-4 mAb shortly before ear challenge showed increased ear swelling responses, this being accompanied by enhanced IFNγ, IL-2, and IL-12 mRNA signals in the dermis.…”

Section: Discussionmentioning

confidence: 99%

Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma

et al. 2019

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Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some synthetic compounds, such as diphenylcyclopropenone (DPCP), are capable of triggering a DTH response in cutaneous malignancies and also to induce clinically relevant effects against melanoma. In this work, we evaluated Litre extract (LExT), a standardized extract of a Chilean stinging plant, Lithraea caustic (Litre). As Litre plant is known to induce DTH, we used a murine B16 melanoma model to compare the topical and intratumor efficacy of LExT with synthetic DTH inducers (DPCP and 2,4-dinitrochlorobenzene [DNCB]). LExt contained mainly long chain catechols and sesquiterpenes. The intratumor injection of LExT induced a significant delay in tumor growth, similarly topical treatment of an established tumor with 0.1% LExT ointment induced a growth delay and even tumor regression in 15% of treated animals. No significant changes were observed on the T-cell populations associated to LExT treatment, and neither DNCB nor DPCP were capable to induce none of the LExT-induced antitumoral effects. Interestingly, our results indicate that LExT induces an antitumor response against melanoma in a mouse model and could bring a new –and affordable- treatment for melanoma in humans.

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“…Selenium substitutions of L-Methionine are known as L-Selenomethionine or L-Selenoneine. These amino acids have high antioxidant activities, and L-Selenomethionine can suppress allergic dermatitis 11 . Thus, the high value for L-Methionine was likely due to the existence of L-Selenomethionine and L-Selenoneine.…”

Section: Analysis Of Amino Acids By Uhplcmentioning

confidence: 99%

Evaluation of Antioxidant Activity and Amino Acids in the Mucus of Mackerel for Cosmetic Applications

Tagami

Kuwahara

2020

J. Oleo Sci.

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IntroductionThe stratum corneum of the skin is located at the boundary between the inside of the skin and outside environment, functioning as a barrier against stimulation from the outside environment. When barrier function decreases, the water retained in the stratum corneum evaporates, leading to dry skin, which can cause inflammation and itching. This study is based on interview survey results that revealed improvement in symptoms such as atopic dermatitis and rough, itchy hands in people who had been handling mackerel for a long time. Previous studies of fish mucus reported the structure and functions of glycoprotein lectins, mucin, antioxidant, and antimicrobial peptides 1 4 . Glycoprotein, lectins, and mucin are high-molecular-weight materials, whereas antioxidants and antimicrobial peptides are low-molecular-weight materials. The mucus of fish is predominantly composed of the mucins of glycoprotein, whose amino acid compositions differ depending on the species 5 . Antioxidants and antimicrobial peptides are less susceptible to heat denaturation than proteins such as lectins and mucins.

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Effects of Supplementary Seleno-L-methionine on Atopic Dermatitis-Like Skin Lesions in Mice

Cited by 8 publications

References 43 publications

Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy

Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy

Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma

Evaluation of Antioxidant Activity and Amino Acids in the Mucus of Mackerel for Cosmetic Applications

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