Effects of superfine grinding on physicochemical and antioxidant properties of Lycium barbarum polysaccharides

Zhang, Min; Fang, Wang; Liu, Rui; Tang, Xiuli; Zhang, Qian; Zhang, Zesheng

doi:10.1016/j.lwt.2014.04.020

Cited by 94 publications

(72 citation statements)

References 35 publications

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“…Zhang defined that superfine powder as small size solid particles from 4 µm to 200 µm [14]. It is usually used in different fields such as food industry.…”

Section: Introductionmentioning

confidence: 99%

Effect of Superfine Grinding on the Phytochemicals and Antioxidant Activities of Mulberry Leaves

Mena¹

2016

SJPH

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Abstract:In this study, two species of mulberry leaves were used as materials and four different size powders (about 20-115 µm, 15-20 µm, 10-15 µm and <10 µm) were prepared. The effects of superfine grinding (SG) on the extraction of active components from mulberry leaves (MLs) and their antioxidant activities were investigated. The results indicated that the contents of the active component such as polyphenol, polysaccharides, alkaloids were increased markedly with the decreasing in the particle size, but there was a bit difference in flavonoids. Additionally, the antioxidants properties of MLs treated on 1,1-diphel-2-picrylhydraxyl (DPPH) radical scavenging activity and ferric reducing antioxidant power (FRAP) were also increased, but the scavenging activity in hydroxyl radical scavenging assay (HAS) decreased in the size of D10. These results indicated that SG could improve the extraction efficiency of active components from MLs and make its antioxidant activity enhance, implying that SG can be an effective way to improve the quality and functionality of MLs in foodstuff and pharmacological field.

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“…Zhang defined that superfine powder as small size solid particles from 4 µm to 200 µm [14]. It is usually used in different fields such as food industry.…”

Section: Introductionmentioning

confidence: 99%

Effect of Superfine Grinding on the Phytochemicals and Antioxidant Activities of Mulberry Leaves

Mena¹

2016

SJPH

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“…24 Modern scientific research and experiments have proved that polysaccharides are the main bioactive constituents in L. barbarum. 25 It has also been proved that L. barbarum polysaccharides (LBP) possess various bioactivities, including immunomodulatory, [26][27][28] antioxidant, 29 antitumor, 30,31 and hypoglycemic activities. 32 However, LBP also have some disadvantageous characteristics, such as low bioavailability and limited formulation methods, which limit its development for future clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Simple nanoliposomes encapsulating <em>Lycium barbarum</em> polysaccharides as adjuvants improve humoral and cellular immunity in mice

Sun

Zhou³

et al. 2017

IJN

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The success of subunit vaccines has been hampered by the problems of weak or short-term immunity and the lack of availability of nontoxic, potent adjuvants. It would be desirable to develop safe and efficient adjuvants with the aim of improving the cellular immune response against the target antigen. In this study, the targeting and sustained release of simple nanoliposomes containing Lycium barbarum polysaccharides (LBP) as an efficacious immune adjuvant to improve immune responses were explored. LBP liposome (LBPL) with high entrapment efficiency (86%) were obtained using a reverse-phase evaporation method and then used to encapsulate the model antigen, ovalbumin (OVA). We demonstrated that the as-synthesized liposome loaded with OVA and LBP (LBPL-OVA) was stable for 45 days and determined the encapsulation stability of OVA at 4°C and 37°C and the release profile of OVA from LBPL-OVA was investigated in pH 7.4 and pH 5.0. Further in vivo investigation showed that the antigen-specific humoral response was correlated with antigen delivery to the draining lymph nodes. The LBPL-OVA were also associated with high levels of uptake by key dendritic cells in the draining lymph nodes and they efficiently stimulated CD4 + and CD8 + T cell proliferation in vivo, further promoting antibody production. These features together elicited a significant humoral and celluar immune response, which was superior to that produced by free antigen alone.

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“…These compounds present antioxidant effects by inhibiting production of oxygen radicals, and scavenging hydroxyl radicals (OH•) and superoxide anion (O 2 -•) [3]. Lycium barbarum is the dry fruit of Lycium barbarum belonging to Solanaceae.…”

Section: Introductionmentioning

confidence: 99%

Preparation of polysaccharide loaded collagen membrane with anti-oxidative activity

Shu

Ding

et al. 2015

BME

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Abstract. The scavenging activity of polysaccharides from Lycium barbarum, Lentinus edodes and Ganoderma Lucidum Karst to DPPH free radicals was investigated. It was found that among the three polysaccharides, Lycium barbarum polysaccharides (LBP) exhibits the best scavenging activity. Polysaccharide loaded collagen membranes were prepared by mixing LBP with collagen, starch, glycerol, sodium carboxymethyl cellulose and glutaraldehyde. In vitro drug release from membranes was evaluated. With increasing the immersion time, the release rate first increases and then slows down. Meanwhile, the scavenging activity to DPPH radicals exhibits similar variation, in agreement with a good release effect of the membrane. The optimal formulation of collagen membrane and preparation parameters were obtained considering the overall properties and the scavenging activity to radicals.

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Effects of superfine grinding on physicochemical and antioxidant properties of Lycium barbarum polysaccharides

Cited by 94 publications

References 35 publications

Effect of Superfine Grinding on the Phytochemicals and Antioxidant Activities of Mulberry Leaves

Effect of Superfine Grinding on the Phytochemicals and Antioxidant Activities of Mulberry Leaves

Simple nanoliposomes encapsulating <em>Lycium barbarum</em> polysaccharides as adjuvants improve humoral and cellular immunity in mice

Preparation of polysaccharide loaded collagen membrane with anti-oxidative activity

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