Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats

Guo, Xiaorui; Lu, Huiying; Liu, Chunxiang; Zhang, Yi; Bi, Liangjia

doi:10.2147/dddt.s363766

Cited by 3 publications

(2 citation statements)

References 54 publications

(66 reference statements)

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“…Hence, thirty-six albino Wistar rats (35 days old) [23] of either sex, weighing 180-200 g [24], were procured from the University of Veterinary and Animal Sciences, Lahore, Pakistan for this study. Animals that were pregnant or died during the study period were excluded [25].…”

Section: Methodsmentioning

confidence: 99%

Histological evaluation of wound healing by topical phenytoin application on extraction socket: anin vivostudy in albino Wistar rats

Christopher¹,

Fazal²,

Mehdi

et al. 2023

J Oral Med Oral Surg

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Objective: To investigate the effects of topical phenytoin application on wound healing of extraction socket of albino Wistar rats. Materials and methods: Thirty-six albino Wistar rats were randomly divided into Group A (control), B (1% phenytoin mucoadhesive paste), and C (mucoadhesive paste without phenytoin). All animals were anesthetized followed by first molar extraction. Group A did not receive any agent, whereas, Group B and C received daily application of their respective pastes. Four animals from each group were sacrificed on day 7, 14, and 21 and analyzed histologically. Results: No significant difference was found in blood vessel count among the groups. Statistical increase in percentage of fibroblast in Group B was found as compared with other groups at day 7, whereas, no significant difference was found among groups at day 14. Day 21 showed significant decrease in percentage of fibroblasts in Group B (p-value < 0.001) as compared with Group A and C. Increase in percentage of bone trabeculae in Group B was observed on day 7, 14, and 21 with a significant difference (p-value < 0.05) as compared to Group A and C. Conclusion: Topical application of phenytoin promoted fibroblast proliferation and bone trabeculae formation during healing of extraction socket in rats.

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Section: Methodsmentioning

confidence: 99%

Histological evaluation of wound healing by topical phenytoin application on extraction socket: anin vivostudy in albino Wistar rats

Christopher¹,

Fazal²,

Mehdi

et al. 2023

J Oral Med Oral Surg

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“…The article [7]: 36 rats were divided into two groups: the first group of mice ( 18) -after tooth extraction, they were injected with super active platelet lysate; the second group (18) -control group, after extraction, 2 ml of saline was injected. According to the MRI results, it was concluded that in the first group, bone tissue deposition was noticed 10 days after tooth extraction, but in the control group there was no such bone volume as in the first group.…”

Section: The Use Of Super Active Platelet Lysate As a Stimulating Sub...mentioning

confidence: 99%

Methods of socket preservation: literature review

Voronov,

Melikova,

Fokina

et al. 2023

Èndodontiâ today

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Aim. To analyze different methods of socket preservation. This procedure plays important role in the placement of implants, since due to this procedure, the bone that was left after the tooth extraction is going to be preserved. Also this procedure promote bone formation that is very significant for the reliable placement of implants. Materials and methods. Was produced the study of the publications from PubMed, Cyberleninka , Google Scholar during the systematic review of the literature.Selected and included articles, the content of which concerns different methods of the socket preservation and their role on the bone tissue. Results: 78 publications were reviewed. After analyzing the literature for inclusion criteria, the total number of publications has become 50. Conclusions. According to the analyzed data, there are different methods of the socket preservation that lead to a successful result. However there are some methods that lead to a deterioration result for some patients. Therefore, at this moment investigating different methods of the socket preservation is not ended.

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Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction

Yang

Liu

et al. 2022

Front. Endocrinol.

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Diabetes mellitus is a common systematic chronic disease amongst dental patients. The elevated glucose microenvironment can prolong the healing of tooth extraction sockets. Therefore, the promotion of healing up tooth extraction sockets is of great clinical importance to the patients with diabetes mellitus. The current evidence indicates the mechanism of the recovery period of extraction sockets in hyperglycaemia conditions from physiological, inflammation, immune, endocrine and neural aspects. New advancements have been made in varied curative approaches and drugs in the management of wound healing of tooth extraction sockets in diabetes. However, most of the interventions are still in the stage of animal experiments, and whether it can be put into clinical application still needs further explorations. Specifically, our work showed topical administration of plasma-rich growth factor, advanced platelet-rich fibrin, leukocyte- and platelet-rich fibrin and hyaluronic acid as well as maxillary immediate complete denture is regarded as a promising approach for clinical management of diabetic patients requiring extractions. Overall, recent studies present a blueprint for new advances in novel and effective approaches for this worldwide health ailment and tooth extraction sockets healing.

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Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats

Cited by 3 publications

References 54 publications

Histological evaluation of wound healing by topical phenytoin application on extraction socket: anin vivostudy in albino Wistar rats

Histological evaluation of wound healing by topical phenytoin application on extraction socket: anin vivostudy in albino Wistar rats

Methods of socket preservation: literature review

Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction

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