Effects of Substance P on Pancreatic Exocrine Secretion Stimulated by Secretin, Dopamine and Cholecystokinin in Dogs

Iwatsuki, Kazuhiko; Yamagishi, F; Chiba, Shigetoshi

doi:10.1111/j.1440-1681.1986.tb02395.x

Cited by 13 publications

(5 citation statements)

References 22 publications

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“…In vivo studies have also provided conflicting data. Substance P stimulated basal amylase secretion (86) and potentiated CCK-and caerulein-stimulated amylase secretion in some dog studies (66,73,155), but others reported inhibited secretin-and caeruleinstimulated exocrine secretion (66,86). Similarly, substance P inhibited both CCK-stimulated amylase secretion and secretinstimulated flow of pancreatic juice in the isolated vascular perfused rat pancreas (81).…”

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 92%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

105

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Although the role of the islets in the regulation of acinar cell function seemed a mystery to investigators who observed their dispersion among pancreatic acini, over time an appreciation for this intricate and unique structural arrangement has developed. The last three decades have witnessed a steadily growing understanding of the interrelationship of the endocrine and the exocrine pancreas. The islet innervation and vascular anatomy have been more fully characterized and provide an appropriate background for our current understanding. The interrelationship between the endocrine and exocrine pancreas is mediated by islet-derived hormones such as insulin and somatostatin, other humoral factors including pancreastatin and ghrelin, and also neurotransmitters (nitric oxide, peptide YY, substance P, and galanin) released by the nerves innervating the pancreas. Although considerable progress has been achieved, further work is required to fully delineate the complex interplay of the numerous mechanisms involved. This review aims to provide a comprehensive update of the current literature available, bringing together data gleaned from studies addressing the actions of individual hormones, humoral factors, and neurotransmitters on the regulation of amylase secretion from the acinar cell. This comprehensive view of the islet-acinar axis of the pancreas while acknowledging the dominant role played by insulin and somatostatin on exocrine secretion sheds light on the influence of the various neuropeptides on amylase secretion.

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Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 92%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

105

View full text Add to dashboard Cite

show abstract

“…The undecapeptide SP has been shown to inhibit secretin-stimulated secretion from the pancreas of the dog (11,15) and rat (12). SP-like immunoreactivity has been identified in the pancreas of the dog, rat, and mouse (21), although it has not been localized around the ducts (24).…”

mentioning

confidence: 99%

Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger

Hegyi¹,

Gray²,

Argent³

2003

American Journal of Physiology-Cell Physiology

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The stimulatory pathways controlling HCO 3 Ϫ secretion by the pancreatic ductal epithelium are well described. However, only a few data are available concerning inhibitory mechanisms, which may play an important role in the physiological control of the pancreas. The aim of this study was to investigate the cellular mechanism by which substance P (SP) inhibits pancreatic ductal HCO 3 Ϫ secretion. Small intra/interlobular ducts were isolated from the pancreas of guinea pigs. During overnight culture the ducts seal to form a closed sac. Transmembrane HCO 3 Ϫ fluxes were calculated from changes in intracellular pH (measured using the pH-sensitive dye BCECF) and the buffering capacity of the cells. We found that secretin can stimulate HCO 3 Ϫ secretion in guinea pig pancreatic ducts about fivefold and that this effect could be totally blocked by SP. The inhibitory effect of SP was relieved by spantide, an SP receptor antagonist. SP had no effect on the activity of basolateral Na ϩ -HCO 3 Ϫ cotransporters and Na ϩ /H ϩ exchangers. However, the peptide did inhibit a Cl Ϫ -dependent HCO 3

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“…− and fluid secretion. Substance P strongly inhibits in vivo pancreatic fluid secretion in multiple species such as the dog, 181,182 rat, and mouse. 183 Moreover, SP inhibits both basal-and secretin-stimulated fluid secretion of isolated rat and guinea pig pancreatic ducts in vitro, 146,184 suggesting a direct action of SP on pancreatic duct cells.…”

Section: Substance Pmentioning

confidence: 99%

The Physiology and Pathophysiology of Pancreatic Ductal Secretion

Pallagi¹,

Hegyi²,

Rakonczay³

2015

Pancreas

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The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to 140 mM NaHCO3, which is essential for normal digestion. This article provides an overview of the basics of pancreatic ductal physiology and pathophysiology. In the first part of the article, we discuss the ductal electrolyte and fluid transporters and their regulation. The central role of cystic fibrosis transmembrane conductance regulator (CFTR) is highlighted, which is much more than just a Cl channel. We also review the role of pancreatic ducts in severe debilitating diseases such as cystic fibrosis (caused by various genetic defects of cftr), pancreatitis, and diabetes mellitus. Stimulation of ductal secretion in cystic fibrosis and pancreatitis may have beneficial effects in their treatment.

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Effects of Substance P on Pancreatic Exocrine Secretion Stimulated by Secretin, Dopamine and Cholecystokinin in Dogs

Cited by 13 publications

References 22 publications

The islet-acinar axis of the pancreas: more than just insulin

The islet-acinar axis of the pancreas: more than just insulin

Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger

The Physiology and Pathophysiology of Pancreatic Ductal Secretion

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