Effects of Subcortical Cerebral Infarction on Cortical Glucose Metabolism and Cognitive Function

Abstract

These results demonstrate that subcortical infarction produces global cerebral hypometabolism, which is related to the clinical status of the patients. In addition, specific frontal lobe hypometabolism also appears to be a feature of subcortical infarction. Taken together, both global and regional effects on cortical function mediate the production of clinical symptoms in patients with subcortical strokes.

Mild Cognitive Impairment after Lacunar Infarction: Voxel-Based Morphometry and Neuropsychological Assessment

“…These findings might be interpreted as corroborating and extending findings from the functional neuroimaging literature on the remote effects of subcortical damage beyond the immediate area of infarction [28, 29]. Hence, in addition to the aforementioned subcortical abnormalities in the basal ganglia, our results indicate that regional gray-matter damage contributes to the cognitive picture of MCI-V.…”

Mild Cognitive Impairment after Lacunar Infarction: Voxel-Based Morphometry and Neuropsychological Assessment

“…These findings might be interpreted as corroborating and extending findings from the functional neuroimaging literature on the remote effects of subcortical damage beyond the immediate area of infarction [28, 29]. Hence, in addition to the aforementioned subcortical abnormalities in the basal ganglia, our results indicate that regional gray-matter damage contributes to the cognitive picture of MCI-V.…”

EEG in Silent Small Vessel Disease

“…Subcortical lacunar infarcts and white matter lesions regardless of their location impair frontal lobe function (Reed et al, 2004;Tullberg et al, 2004) with a negative impact on cognitive status (Kuczynski et al, 2008;Kwan et al, 1999;Reed et al, 2001), consistent with the hypothesis of disruption of frontosubcortical circuits in subcortical vascular cognitive impairment (Cummings, 1994). Cognitive impairment secondary to subcortical infarcts is often accompanied by generalized cortical blood flow and metabolic changes (De Reuck et al, 1998;Sultzer et al, 1995).…”

Membranous lipodystrophy presenting with palilalia: a PET study of cerebral glucose metabolism

“…Our PET study disclosed clearly decreased regional cerebral glucose metabolism in the bilateral frontal white matter and hypometabolism in the thalamus and the basal ganglia to a lesser degree, all predominantly on the right. Recently, the PET study revealed that subcortical cerebral infarction manifesting cognitive impairment was associated with frontal lobe hypometabolism (6). These ®ndings support the notion that impairment of frontal subcortical structures and frontal lobe dysfunction might produce these symptoms in NHD.…”

Mild Cognitive Impairment after Lacunar Infarction: Voxel-Based Morphometry and Neuropsychological Assessment

“…These findings might be interpreted as corroborating and extending findings from the functional neuroimaging literature on the remote effects of subcortical damage beyond the immediate area of infarction [28, 29]. Hence, in addition to the aforementioned subcortical abnormalities in the basal ganglia, our results indicate that regional gray-matter damage contributes to the cognitive picture of MCI-V.…”

EEG in Silent Small Vessel Disease

“…Subcortical lacunar infarcts and white matter lesions regardless of their location impair frontal lobe function (Reed et al, 2004;Tullberg et al, 2004) with a negative impact on cognitive status (Kuczynski et al, 2008;Kwan et al, 1999;Reed et al, 2001), consistent with the hypothesis of disruption of frontosubcortical circuits in subcortical vascular cognitive impairment (Cummings, 1994). Cognitive impairment secondary to subcortical infarcts is often accompanied by generalized cortical blood flow and metabolic changes (De Reuck et al, 1998;Sultzer et al, 1995).…”

Membranous lipodystrophy presenting with palilalia: a PET study of cerebral glucose metabolism

“…Our PET study disclosed clearly decreased regional cerebral glucose metabolism in the bilateral frontal white matter and hypometabolism in the thalamus and the basal ganglia to a lesser degree, all predominantly on the right. Recently, the PET study revealed that subcortical cerebral infarction manifesting cognitive impairment was associated with frontal lobe hypometabolism (6). These ®ndings support the notion that impairment of frontal subcortical structures and frontal lobe dysfunction might produce these symptoms in NHD.…”

Mild Cognitive Impairment after Lacunar Infarction: Voxel-Based Morphometry and Neuropsychological Assessment

“…These findings might be interpreted as corroborating and extending findings from the functional neuroimaging literature on the remote effects of subcortical damage beyond the immediate area of infarction [28, 29]. Hence, in addition to the aforementioned subcortical abnormalities in the basal ganglia, our results indicate that regional gray-matter damage contributes to the cognitive picture of MCI-V.…”

EEG in Silent Small Vessel Disease

“…Subcortical lacunar infarcts and white matter lesions regardless of their location impair frontal lobe function (Reed et al, 2004;Tullberg et al, 2004) with a negative impact on cognitive status (Kuczynski et al, 2008;Kwan et al, 1999;Reed et al, 2001), consistent with the hypothesis of disruption of frontosubcortical circuits in subcortical vascular cognitive impairment (Cummings, 1994). Cognitive impairment secondary to subcortical infarcts is often accompanied by generalized cortical blood flow and metabolic changes (De Reuck et al, 1998;Sultzer et al, 1995).…”

Membranous lipodystrophy presenting with palilalia: a PET study of cerebral glucose metabolism

“…Our PET study disclosed clearly decreased regional cerebral glucose metabolism in the bilateral frontal white matter and hypometabolism in the thalamus and the basal ganglia to a lesser degree, all predominantly on the right. Recently, the PET study revealed that subcortical cerebral infarction manifesting cognitive impairment was associated with frontal lobe hypometabolism (6). These ®ndings support the notion that impairment of frontal subcortical structures and frontal lobe dysfunction might produce these symptoms in NHD.…”