Effects of subclinical pregnancy toxemia on immune responses in sheep

Lacetera, Nicola; Bernabucci, U.; Ronchi, Bruno; Nardone, A.

doi:10.2460/ajvr.2001.62.1020

Cited by 56 publications

(54 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During the Re-Fed period, NEFA concentration returned to initial levels. An increase in plasma concentration of NEFA is usually associated with impaired immune function both in cow (Burvenich et al, 2007) and sheep (Lacetera et al, 2001(Lacetera et al, , 2002, that could increase incidence of mastitis (Janosi et al, 2003) and milk SCC (Nyman et al, 2008). In our experiment, milk SCC was not statistically influenced by sampling (P=0.126).…”

Section: Bcssupporting

confidence: 50%

Effects of short-term feed restriction on milk yield and composition, and hormone and metabolite profiles in mid-lactation Sarda dairy sheep with different body condition score

Pulina

Nudda

Battacone

et al. 2012

Italian Journal of Animal Science

View full text Add to dashboard Cite

Section: Bcssupporting

confidence: 50%

Effects of short-term feed restriction on milk yield and composition, and hormone and metabolite profiles in mid-lactation Sarda dairy sheep with different body condition score

Pulina

Nudda

Battacone

et al. 2012

Italian Journal of Animal Science

View full text Add to dashboard Cite

“…Vale ressaltar que apesar das diferenças estatísticas observadas, os valores de β-hidroxibutirato situaram-se dentro da normalidade para a espécie, ou seja, abaixo de 0,6mmol/L, indicando não ter ocorrido lipomobilização nas ovelhas estudadas (Contreras et al 2000). Valores semelhantes aos observados neste trabalho, também foram relatados por Brito (2004) ao longo da lactação e Lacetera et al (2001), que encontraram índices de β-hidroxibutirato entre 0,32mmol/L e 0,42mmol/L em ovelhas saudáveis, diferentemente das ovelhas com toxemia da prenhez (0,89mmol/L a 1,30mmol/L).…”

Section: Perfil Metabólico E Enzimáticounclassified

“…Acomete tanto ovelhas quanto cabras e está associada com subnutrição e particularmente condição de obesidade destas espécies a partir da segunda gestação de dois ou mais fetos (NRC 1985, Sargison et al 1994, Rook 2000, Lacetera et al 2001. Este distúrbio caracteriza-se por hipoglicemia, cetose e acidose metabólica, podendo apresentar sinais clínicos de doença nervosa e digestiva, que culminam freqüentemente com a morte do animal (Afonso 2006, Schlumbohm & Harmeyer 2008.…”

Section: Introductionunclassified

Efeito da administração de propileno glicol e cobalto associado à vitamina B12 sobre o perfil metabólico e a atividade enzimática de ovelhas da raça Santa Inês no periparto

et al. 2012

View full text Add to dashboard Cite

Pesq. Vet. Bras. 32(Supl. The aim of this study was to evaluate the influence of the administration of propylene glycol and cobalt associated with vitamin B12 on the metabolic profile and enzymatic activity of Santa Inês ewes in the peripartum period. A total of 18 pregnant ewes, weighing around 40kg were used. Approximately 30 days before the expected date of delivery were randomly separated into three groups and administered supplements as follows: (G1/n = 6) group received propylene glycol (30mL orally daily); (G2/n = 6) group receiving cobalt (1mg cobalt chloride 1%, orally daily) associated with vitamin B12 (2mg intramuscular weekly) and (G3/n = 6) control group. Blood samples from ewes to evaluate the enzymatic and metabolic profile (glucose, β-hydroxybutyrate, BHB, NEFA, total protein, albumin, urea, creatinine, AST, GGT, ALP and CK) were taken 30 days before the date set for delivery, one week before (ante partum), delivery at 24h, 72h, 5 days, 15 days and 30 days after delivery. ketonuria was not observed in pre partum. The administration of supplements had no effect on the metabolic profile, protein and energy, and no liver disorders was observed in peripartum.

show abstract

“…Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation as already described (Lacetera et al 2001) with minor modifications. Briefly, blood diluted in phosphate-buffered saline (PBS, Sigma, Milano, Italy) was layered over Ficoll-Paque PLUS (APB, Milano, Italy) and centrifuged.…”

Section: Isolation Of Peripheral Blood Mononuclear Cellsmentioning

confidence: 99%

The Hsp72 response in peri-parturient dairy cows: relationships with metabolic and immunological parameters

Catalani

Amadori

Vitali

et al. 2010

Cell Stress and Chaperones

Self Cite

View full text Add to dashboard Cite

The study was aimed at assessing whether the peri-parturient period is associated with changes of intracellular and plasma inducible heat shock proteins (Hsp) 72 kDa molecular weight in dairy cows, and to establish possible relationships between Hsp72, metabolic, and immunological parameters subjected to changes around calving. The study was carried out on 35 healthy periparturient Holstein cows. Three, two, and one week before the expected calving, and 1, 2, 3, 4, and 5 weeks after calving, body conditions score (BCS) was measured and blood samples were collected to separate plasma and peripheral blood mononuclear cells (PBMC). Concentrations of Hsp72 in PBMC and plasma increased sharply after calving. In the post-calving period, BCS and plasma glucose declined, whereas plasma nonesterified fatty acids (NEFA) and tumor necrosis factor-alpha increased. The proliferative responses of PBMC to lipopolysaccharide (LPS) declined progressively after calving. The percentage of PBMC expressing CD14 receptors and Toll-like receptors (TLR)-4 increased and decreased in the early postpartum period, respectively. Correlation analysis revealed significant positive relationships between Hsp72 and NEFA, and between PBMC proliferation in response to LPS and the percentage of PBMC expressing TLR-4. Conversely, significant negative relationships were found between LPS-triggered proliferation of PBMC and both intracellular and plasma Hsp72. Literature data and changes of metabolic and immunological parameters reported herein authorize a few interpretative hypotheses and encourage further studies aimed at assessing possible cause and effect relationships between changes of PBMC and circulating Hsp72, metabolic, and immune parameters in dairy cows.

show abstract

Effects of subclinical pregnancy toxemia on immune responses in sheep

Abstract: Results suggest that subclinical PT may be associated with impairments in cell-mediated and humoral immune responses in sheep.

Cited by 56 publications

References 22 publications

Effects of short-term feed restriction on milk yield and composition, and hormone and metabolite profiles in mid-lactation Sarda dairy sheep with different body condition score

Effects of short-term feed restriction on milk yield and composition, and hormone and metabolite profiles in mid-lactation Sarda dairy sheep with different body condition score

Efeito da administração de propileno glicol e cobalto associado à vitamina B12 sobre o perfil metabólico e a atividade enzimática de ovelhas da raça Santa Inês no periparto

The Hsp72 response in peri-parturient dairy cows: relationships with metabolic and immunological parameters

Contact Info

Product

Resources

About