Effects of Sub-Acute Exposure to Rhodium (as Rh (III) chloride hydrate) on Cytokines in Female Wistar Rats

Iavicoli, Ivo; Sgambato, Alessandro; Fontana, Luca; Marinaccio, Alessandro; Leso, Veruscka; Corbi, Maddalena; Bergamaschi, Antonio; Calabrese, Edward J.

doi:10.1007/s00128-012-0720-x

Cited by 6 publications

(1 citation statement)

References 19 publications

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“…Only few reports on the (predominantly immunosuppressive) influence of Rh on the immune system exist. Hence, exposure of female Wistar rats to Rh(III) chloride (RhCl 3 ) via drinking water revealed a generalized decrease of cytokine levels in the serum, with the exception of IL-1α and IL-2, 833 suggesting an anti-inflammatory role of this Rh salt. Similar inhibitory effects on cytokine production (including IFN-γ, TNF-α, and IL-5) have been observed in PBMC, using the complex ammonium hexachloridorhodate ((NH 4 ) 3 [RhCl 6 ]) or the salt RhCl 3 , 834 again indicating these compounds to exert rather inhibitory effects on immune cells.…”

Section: Rhodium (Rh)mentioning

confidence: 99%

Metal Drugs and the Anticancer Immune Response

et al. 2018

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The immune system deploys a multitude of innate and adaptive mechanisms not only to ward off pathogens but also to prevent malignant transformation ("immune surveillance"). Hence, a clinically apparent tumor already reflects selection for those malignant cell clones capable of evading immune recognition ("immune evasion"). Metal drugs, besides their well-investigated cytotoxic anticancer effects, massively interact with the cancer-immune interface and can reverse important aspects of immune evasion. This topic has recently gained intense attention based on combination approaches with anticancer immunotherapy (e.g., immune checkpoint inhibitors), a strategy recently delivering first exciting results in clinical settings. This review summarizes the promising but still extremely fragmentary knowledge on the interplay of metal drugs with the fidelity of anticancer immune responses but also their role in adverse effects. It highlights that, at least in some cases, metal drugs can induce long-lasting anticancer immune responses. Important steps in this process comprise altered visibility and susceptibility of cancer cells toward innate and adaptive immunity, as well as direct impacts on immune cell populations and the tumor microenvironment. On the basis of the gathered information, we suggest initiating joint multidisciplinary programs to implement comprehensive immune analyses into strategies to develop novel and smart anticancer metal compounds.

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Section: Rhodium (Rh)mentioning

confidence: 99%

Metal Drugs and the Anticancer Immune Response

et al. 2018

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Ruthenium, Rhodium, Palladium, and Osmium

Graham¹,

Haley

2023

Patty's Toxicology

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Ruthenium, rhodium, palladium, and osmium are four of the six platinum group metals (the other two are iridium and platinum). These naturally occurring metals are often found in the environment (e.g., airborne) due to their use in vehicle exhaust catalysts and consequent release in car exhaust from catalytic converters. The toxicity, absorption, distribution, and excretion of ruthenium, rhodium, palladium, and osmium and/or their complexes are generally dependent on the route of exposure/administration. These compounds also tend to be skin and eye irritants. Sensitization is often a concern when handling and/or exposed to these metals in the occupational setting as sensitization reactions to each of these metals and/or their complexes (aside from osmium) have been reported. Additionally, cross‐reactions (positive prick tests) in humans have been observed to platinum, palladium, iridium, and rhodium as well as to palladium and nickel. Environmental monitoring studies for several of these metals have found that the (airborne) levels are expected to be below the values thought to cause adverse health effects in humans.

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Biomonitoring of Platinum Group Elements (PGEs) in Occupational Medicine

Iavicoli

Leso

2014

Environmental Science and Engineering

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Platinum, palladium, rhodium and iridium are platinum group elements (PGEs) employed in several industrial, chemical, and electronic applications and as active catalyst materials in automotive converters. However, despite the widespread use of these metals and their increasing emission into the environment due to the abrasion of catalytic devices, little is known of their toxic effects. Considerable concern has therefore arisen over the potential health risks for the general population and particularly for workers exposed to PGEs during production and recycling activities or via traffic emissions. Consequently, biological monitoring is important in order to assess PGE exposure, early effects and susceptibility factors so that occupational risks can be adequately evaluated and managed. This chapter aims to evaluate potential biomarkers of occupational PGE exposure and discuss issues regarding future research aimed at determining indicators of early PGE effects and susceptibility, and focus on the relevance and feasibility of these potential biomarkers in occupational health practice

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Effects of Sub-Acute Exposure to Rhodium (as Rh (III) chloride hydrate) on Cytokines in Female Wistar Rats

Cited by 6 publications

References 19 publications

Metal Drugs and the Anticancer Immune Response

Metal Drugs and the Anticancer Immune Response

Ruthenium, Rhodium, Palladium, and Osmium

Biomonitoring of Platinum Group Elements (PGEs) in Occupational Medicine

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