Effects of Structure on the Solubility of UV Filters

Olmo, Marc del; Navarro, Àngel; García, C.; Ehara, Taro; Beltran, L.

doi:10.3390/cosmetics9030060

Cited by 4 publications

(2 citation statements)

References 16 publications

(21 reference statements)

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“…There were concerns regarding whether MAA water solubility could present an additional challenge when using these molecules within sunscreen formulations for UVR protection during aquatic activities [18]. However, the main component of all sunscreens is water, and it is critical to have appropriate solubilization of these UV filters [82]. For example, other sunscreen formulations successfully used water-soluble synthetic UV filters such as benzophenone-4 [83], indicating that the hydrophilic nature of MAAs should not prevent their use in sunscreen products.…”

Section: Natural Uv-absorbing Compoundsmentioning

confidence: 99%

Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens

et al. 2023

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Human skin needs additional protection from damaging ultraviolet radiation (UVR: 280–400 nm). Harmful UVR exposure leads to DNA damage and the development of skin cancer. Available sunscreens offer chemical protection from detrimental sun radiation to a certain extent. However, many synthetic sunscreens do not provide sufficient UVR protection due to the lack of photostability of their UV-absorbing active ingredients and/or the lack of ability to prevent the formation of free radicals, inevitably leading to skin damage. In addition, synthetic sunscreens may negatively affect human skin, causing irritation, accelerating skin aging and even resulting in allergic reactions. Beyond the potential negative effect on human health, some synthetic sunscreens have been shown to have a harmful impact on the environment. Consequently, identifying photostable, biodegradable, non-toxic, and renewable natural UV filters is imperative to address human health needs and provide a sustainable environmental solution. In nature, marine, freshwater, and terrestrial organisms are protected from harmful UVR through several important photoprotective mechanisms, including the synthesis of UV-absorbing compounds such as mycosporine-like amino acids (MAAs). Beyond MAAs, several other promising, natural UV-absorbing products could be considered for the future development of natural sunscreens. This review investigates the damaging impact of UVR on human health and the necessity of using sunscreens for UV protection, specifically UV-absorbing natural products that are more environmentally friendly than synthetic UV filters. Critical challenges and limitations related to using MAAs in sunscreen formulations are also evaluated. Furthermore, we explain how the genetic diversity of MAA biosynthetic pathways may be linked to their bioactivities and assess MAAs’ potential for applications in human health.

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Section: Natural Uv-absorbing Compoundsmentioning

confidence: 99%

Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens

et al. 2023

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“…Sunscreens used for the protection of human skin against the harmful effects of solar radiation contain high concentrations of UV-absorbing molecules [1,2]. For the use Extended author information available on the last page of the article in sunscreens, such UV filters must be approved by the responsible authorities after toxicological assessment.…”

Section: Introductionmentioning

confidence: 99%

Spectra and photorelaxation of tris-biphenyl-triazine-type UV absorbers: from monomers to nanoparticles

Naumov

Herzog²,

Abel

2023

Photochem Photobiol Sci

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Water-insoluble organic UV filters like tris-biphenyl-triazine (TBPT) can be prepared as aqueous dispersions of nanoparticles. The particles consist of the respective UV absorber molecules and show strong UV absorbance. Since there is a certain solubility of such UV absorbers in organic solvents, it is possible to measure the absorbance spectrum also in solution, for instance in ethanol or dioxane. The UV spectrum of the aqueous dispersion shows a slight hypsochromic shift of the original band with an additional shoulder at longer wavelengths. For the understanding of the observed changes of UV–Vis spectra of this UV absorber, either dissolved in an organic solvent or dispersed as nanoparticles in water, DFT calculations were carried out with the respective monomer and aggregates of TBPT molecules in the different media. The calculated UV–Vis spectra of isolated, that means dissolved, TBPT molecules in ethanol and in dioxane agree well with experimentally observed ones. The observed changes in the shape of experimental UV–Vis spectra in aqueous dispersion cannot be explained with a solvent effect only. It was found that the studied molecules could form stable energetically favorable π-stacked aggregates, which show UV–Vis spectra in reasonable agreement with those experimentally observed in aqueous dispersion. Such aggregates of TBPT are most likely the reason for the observed additional shoulder in the UV/vis absorbance spectrum. In addition, the mechanism of the photochemical deactivation of excited TBPT molecules was studied in detail with TD DFT in dioxane and in water. Graphical abstract

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The use of natural extracts with photoprotective activity: a 2015–2023 patent prospection

Oliveira,

de Souza Batista,

de Castro

et al. 2024

Photochem Photobiol Sci

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Effects of Structure on the Solubility of UV Filters

Cited by 4 publications

References 16 publications

Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens

Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens

Spectra and photorelaxation of tris-biphenyl-triazine-type UV absorbers: from monomers to nanoparticles

The use of natural extracts with photoprotective activity: a 2015–2023 patent prospection

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