Effects of structural modification of anti-inflammatory steroidal antedrug on pro-inflammatory mediators and inhibitory cytokines in human alveolar epithelial cells
Abstract:The anti-inflammatory effects of the new steroidal antedrug, 21-acetyloxy-9α-fluoro-11β-hydroxyl-3, 20-dioxo-1, 4-pregnadieno-[16α, 17α-d] isoxazoline (FP-ISO-21AC), on nitric oxide (NO) and interleukin 8 (IL-8) production, were investigated together with its parent steroid prednisolone (PRED). PRED is one of the anti-inflammatory steroids but has systemic side effects which limit the use of it. PRED was modified with 'antedrug concept' to create safer drugs that attack problems such as inflammation, then quic… Show more
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