Effects of structural factors on the spasmolytic activity in a series of derivatives of imidazole and benzimidazole

Synthesis and Analgesic Activity of 1-(1-Piperidinyl)methyl-2-(4-substituted styryl)-5-chlorobenzimidazole Derivatives

“…It is well known that alkylaminoalkyl groups at position 1 of 2-benzylbenzimidazoles confer analgesic activity to these derivatives (Hunger et al 1960). It was reported that some 1-substituted-2styrylbenzimidazole derivatives also had signi®cant analgesic, anti-in¯ammatory and antispasmodic activity (Hoffmann & Hunger 1962;Kamissarov et al 1982). These ®ndings have prompted us to synthesize 1-(1-piperidinyl)methyl-2-(4-substituted styryl)-5-chlorobenzimidazole derivatives, and investigate their analgesic activity.…”