Effects of Strobilanthes crispus Juice on Wound Healing and Antioxidant Enzymes in Normal and Streptozotocin-Induced Diabetic Rats

Norfarizan-Hanoon, N. A.; Asmah, R.; Rokiah, M. Y.; Fauziah, O.; Faridah, Hayyun Durrotul

doi:10.3923/jbs.2009.662.668

Cited by 12 publications

(11 citation statements)

References 29 publications

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“…Next, we examined the expression levels of the main antioxidant enzymes involved in O À 2 /H 2 O 2 scavenging and found decreased levels of MnSOD and GSH-Px protein expression in the skin of diabetic rats. Consistently, different animal [30,31] and human [36] models indicated dysfunction/inactivation of MnSOD and GSH-Px in the diabetic skin. Rising hyperglycemia is known to increase oxidative pressure in tissues through overproduction of O À 2 [4,22,37] and by impaired O À 2 /H 2 O 2 scavenging capacity [36,38,39].…”

Section: Discussionsupporting

confidence: 52%

“…Some therapeutic effect achieved by herbal/fungal (Strobilanthes crispus extracts or Ganoderma lucidum polysaccharide) and other natural products, like xanthohumol, in the treatment of diabetic skin complications at least in part involves suppression of cutaneous antioxidant enzymes inactivation and protein nitration [30][31][32]. Besides, a systemic administration of L-arginine induced regeneration of b cells in rats treated with alloxan [27] and improved healing capacity of skin in aged individuals [33], while a study of Luo et al [22] showed that gene therapy of eNOS or MnSOD accelerated healing in the skin of type I diabetic mice.…”

Section: Discussionmentioning

confidence: 99%

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Targeting the superoxide/nitric oxide ratio byL-arginine and SOD mimic in diabetic rat skin

Janković

Ferreri

Filipović

et al. 2016

Free Radical Research

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Setting the correct ratio of superoxide anion (O) and nitric oxide (NO) radicals seems to be crucial in restoring disrupted redox signaling in diabetic skin and improvement of NO physiological action for prevention and treatment of skin injuries in diabetes. In this study we examined the effects of L-arginine and manganese(II)-pentaazamacrocyclic superoxide dismutase (SOD) mimic - M40403 in diabetic rat skin. Following induction of diabetes by alloxan (blood glucose level ≥12 mMol l) non-diabetic and diabetic male Mill Hill hybrid hooded rats were divided into three subgroups: (i) control, and receiving: (ii) L-arginine, (iii) M40403. Treatment of diabetic animals started after diabetes induction and lasted for 7 days. Compared to control, lower cutaneous immuno-expression of endothelial NO synthase (eNOS), heme oxygenase 1 (HO1), manganese SOD (MnSOD) and glutathione peroxidase (GSH-Px), in parallel with increased NFE2-related factor 2 (Nrf2) and nitrotyrosine levels characterized diabetic skin. L-arginine and M40403 treatments normalized alloxan-induced increase in nitrotyrosine. This was accompanied by the improvement/restitution of eNOS and HO1 or MnSOD and GSH-Px protein expression levels in diabetic skin following L-arginine, i.e. SOD mimic treatments, respectively. The results indicate that L-arginine and M40403 stabilize redox balance in diabetic skin and suggest the underlying molecular mechanisms. Restitution of skin redox balance by L-arginine and M40403 may represent an effective strategy to ameliorate therapy of diabetic skin.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Targeting the superoxide/nitric oxide ratio byL-arginine and SOD mimic in diabetic rat skin

Janković

Ferreri

Filipović

et al. 2016

Free Radical Research

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“…Comparable results were obtained with S. crispa juice in diabetic and normal rats [45]. Interestingly, the fresh juice from S. crispa leaf stimulated the healing of incision wounds on the back of normal and streptozotocin-induced hyperglycemic rats [46]. These observations are in accordance with the stimulatory effects of a topically applied ethanol extract of S. crispa leaf on excision wounds in the posterior neck area rats [47].…”

Section: Acanthaceae -Strobilanthes Crispa Blumesupporting

confidence: 61%

The Contribution of Javanese Pharmacognosy to Suriname’s Traditional Medicinal Pharmacopeia: Part 1

Mans¹,

Friperson²,

Djotaroeno³

et al. 2022

Natural Drugs From Plants

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The Republic of Suriname (South America) is among the culturally, ethnically, and religiously most diverse countries in the world. Suriname’s population of about 600,000 consists of peoples from all continents including the Javanese who arrived in the country between 1890 and 1939 as indentured laborers to work on sugar cane plantations. After expiration of their five-year contract, some Javanese returned to Indonesia while others migrated to The Netherlands (the former colonial master of both Suriname and Indonesia), but many settled in Suriname. Today, the Javanese community of about 80,000 has been integrated well in Suriname but has preserved many of their traditions and rituals. This holds true for their language, religion, cultural expressions, and forms of entertainment. The Javanese have also maintained their traditional medical practices that are based on Jamu. Jamu has its origin in the Mataram Kingdom era in ancient Java, some 1300 years ago, and is mostly based on a variety of plant species. The many Jamu products are called jamus. The first part of this chapter presents a brief background of Suriname, addresses the history of the Surinamese Javanese as well as some of the religious and cultural expressions of this group, focuses on Jamu, and comprehensively deals with four medicinal plants that are commonly used by the Javanese. The second part of this chapter continues with an equally extensive narrative of six more such plants and concludes with a few remarks on the contribution of Javanese jamus to Suriname’s traditional medicinal pharmacopeia.

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“…Phenolic acids have also been found to have antimicrobial and radical scavenging properties. Plants such as Ageratum conyzoides , Punica granatum , Strobilanthes crispus ,etc contain tannins and gallic acid and have tremendous wound‐healing properties. Free radicals scavenging antioxidant properties of sterols and polyphenols make it useful to reduce lipid peroxidation and reduction in necrosis of cells along with improvement in vascularity…”

Section: Wound‐healing Constituents From Medicinal Herbsmentioning

confidence: 99%

Recent advances on herb‐derived constituents‐incorporated wound‐dressing materials: A review

Thomas

2019

Polymers for Advanced Techs

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Since ancient times, wound dressings have evolved with persistent and substantial changes. Several efforts have been made toward the development of new dressing materials, which can meet the demanding conditions for the treatment of skin wounds. Currently, many studies have been focused on the production and designing of herb‐incorporated wound dressings. Herb‐derived constituents are more effective than conventional medicines because of their nontoxic nature and can be administered over long periods. Herbal medicines in wound healing provide a suitable environment for aiding the natural course of healing. This review mainly focuses on the diverse approaches that have been developed to produce a wound dressing material, which can deliver herb‐derived bioactive constituents in a controlled manner. This review also discusses the common wound‐dressing materials available, basic principles of wound healing, and wound‐healing agents from medicinal plants.

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Effects of Strobilanthes crispus Juice on Wound Healing and Antioxidant Enzymes in Normal and Streptozotocin-Induced Diabetic Rats

Cited by 12 publications

References 29 publications

Targeting the superoxide/nitric oxide ratio byL-arginine and SOD mimic in diabetic rat skin

Targeting the superoxide/nitric oxide ratio byL-arginine and SOD mimic in diabetic rat skin

The Contribution of Javanese Pharmacognosy to Suriname’s Traditional Medicinal Pharmacopeia: Part 1

Recent advances on herb‐derived constituents‐incorporated wound‐dressing materials: A review

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