Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague–Dawley rat strains

Grakalic, Ivana; Schindler, Charles W.; Baumann, Michael H.; Rice, Kenner C.; Riley, Anthony L.

doi:10.1007/s00213-006-0562-5

Cited by 34 publications

(24 citation statements)

References 51 publications

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“…Results from Experiment 1 suggest that acute stress enhances the rewarding effects of lower nicotine doses as expressed by a reduction in the number of conditioning trials needed to produce CPP. N-NP (controls: S-NP) conditioning with nicotine (0.6 mg/kg, s.c.) or saline in the initially non-preferred side of the CPP apparatus, S-P conditioning with saline in the initially preferred side of the CPP apparatus Such results are in line with studies showing that a single stressor exposure 24 h before conditioning enhances amphetamine (Capriles and Cancela 1999), morphine (Dai et al 2006;Grakalic et al 2006;Will et al 1998), and oxycodone (Der-Avakian et al 2007) CPP. Findings from preclinical studies indicate that acute stress plays an important role in relapse to nicotine seeking as measured by reinstatement of nicotine CPP (Leão et al 2009) and self-administration (Bruijnzeel et al 2009;Buczek et al 1999;Zislis et al 2007).…”

Section: Discussionsupporting

confidence: 89%

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Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

2011

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Section: Discussionsupporting

confidence: 89%

“…Acute stress enhances the rewarding effects of several addictive drugs in rodents as measured using conditioned place preference (CPP) (Capriles and Cancela 1999;Dai et al 2006;Der-Avakian et al 2007;Grakalic et al 2006;Matsuzawa et al 1998a, b;Will et al 1998). The mechanisms by which this occurs have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 97%

Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

2011

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“…The relationship between HPA activity and drug withdrawal-induced behavior alteration and changes in the brain stress system has not been elucidated, and contradictory results have been shown. For example, morphine-induced conditioned place preference was decreased by antalarmin, whereas this antagonist did not antagonize the increase in plasma corticosterone levels (Grakalic et al, 2006), which suggests that the changes in place preference conditioning induced by CRF1R blockade are not related to changes in HPA activity. In addition, CRF1R has been shown to play a major role in mediating the effects of CRF on behavioral responses to lorazepam withdrawal but not some of the neuroendocrine effects.…”

Section: Discussionmentioning

confidence: 91%

Effects of Corticotropin-Releasing Factor Receptor-1 Antagonists on the Brain Stress System Responses to Morphine Withdrawal

Navarro‐Zaragoza¹,

Núñez²,

Laorden³

et al. 2010

Mol Pharmacol

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The role of stress in drug addiction is well established. The negative affective states of withdrawal most probably involve recruitment of brain stress neurocircuitry [e.g., induction of hypothalamo-pituitary-adrenocortical (HPA) axis, noradrenergic activity, and corticotropin-releasing factor (CRF) activity]. The present study investigated t$he role of CRF receptor-1 subtype (CRF1R) on the response of brain stress system to morphine withdrawal. The effects of naloxone-precipitated morphine withdrawal on noradrenaline (NA) turnover in the paraventricular nucleus (PVN), HPA axis activity, signs of withdrawal, and c-Fos expression were measured in rats pretreated with vehicle, CP-154526 [N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[3,2-e]pyrimidin-4-amine], or antalarmin (selective CRF1R antagonists). Tyrosine hydroxylase-positive neurons expressing CRF1R were seen at the level of the nucleus tractus solitarius-A 2 cell group in both control and morphine-withdrawn rats. CP-154526 and antalarmin attenuated the increases in body weight loss and irritability that were seen during naloxone-induced morphine withdrawal. Pretreatment with CRF1R antagonists resulted in no significant modification of the increased NA turnover at PVN, plasma corticosterone levels, or c-Fos expression that was seen during naloxone-induced morphine withdrawal. However, blockade of CRF1R significantly reduced morphine withdrawal-induced increases in plasma adrenocorticotropin levels. These results suggest that the CRF1R subtype may be involved in the behavioral and somatic signs and in adrenocorticotropin release (partially) during morphine withdrawal. However, CRF1R activation may not contribute to the functional interaction between NA and CRF systems in mediating morphine withdrawalactivation of brain stress neurocircuitry.

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“…In addition, we predicted that the PNS-exposed pups would be significantly more motivated to interact with the dam, and therefore spend significantly more time in the maternally-conditioned odor portion of the COP apparatus compared to the control pups. Several lines of research have shown that increases in HPA activity lead to enhanced or stronger place preference (Dai et al 2006; Grakalic et al 2006). Yang et al (2006) demonstrated that PNS enhanced conditioned place preference to morphine (Yang et al 2006).…”

Section: Introductionmentioning

confidence: 99%

The effects of prenatal stress on motivation in the rat pup

Harmon

Greenwald

McFarland

et al. 2009

Stress

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Exposure to prenatal stress (PNS) has been shown to induce a set of psychological and behavioral changes in developing offspring. We used the rodent model to investigate whether PNS produces changes in the ability of the pup to express social motivation. We used a set of behavioral tasks including monitoring ultrasonic vocalizations after isolation, a conditioned place preference, and a novel and familiar odor approach test. Pregnant Long–Evans rats were exposed to an unpredictable, variable stressor twice daily during the third week of gestation. Isolation vocalizations were assessed on postnatal day (PND) 10. Pup affinity for the dam was evaluated on PND 15. Typically, pups display a selective preference for an odor-paired environment only after the odor has been associated with the dam. This previous association produces a positive conditioned stimulus (CS). Normally, pups exposed to a neutral CS (odor paired with cotton balls) do not form this place preference. Results indicate that PNS exposed pups had significantly increased distress vocalizations and an equal preference for the positive and neutral conditioned stimuli. This type of alteration in forming early preferences could be detrimental because of decreases in the specificity of social learning and an impaired responsiveness in social relationships.

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Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague–Dawley rat strains

Abstract: These data suggest that the relationship between stress and drug use may be nonmonotonic. The use of these inbred strains in genetic analysis of drug addiction may require reexamination.

Cited by 34 publications

References 51 publications

Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

Effects of Corticotropin-Releasing Factor Receptor-1 Antagonists on the Brain Stress System Responses to Morphine Withdrawal

The effects of prenatal stress on motivation in the rat pup

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