Effects of stress-induced increases of corticosterone on circulating triglyceride levels, biliverdin concentration, and heme oxygenase expression

Butler, Michael W.; Armour, Ellen M.; Minnick, Jennifer A.; Rossi, Marissa L.; Schock, Sydney F.; Berger, Scott E.; Hines, Justin K.

doi:10.1016/j.cbpa.2019.110608

Cited by 7 publications

(5 citation statements)

References 75 publications

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“…This finding confirms the relationship between CORT and metabolism of neutral fats in the liver. However, other researchers have obtained similar results when administering CORT at doses exceeding physiological ones [ 25 , 26 ]. Therefore, we have to own up that the mechanisms by which CORT can affect lipid metabolism remain obscure to date.…”

Section: Discussionsupporting

confidence: 55%

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

Kondashevskaya

Artem’eva

Алексанкина

et al. 2022

J Evol Biochem Phys

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The extraordinary situation of the 2019–2022 pandemic caused a dramatic jump in the incidence of post-traumatic stress disorder (PTSD). PTSD is currently regarded not only as a neuropsychiatric disorder, but also as a comorbidity accompanied by cardiovascular diseases, circulatory disorders, liver dysfunction, etc. The relationship between behavioral disorders and the degree of morphofunctional changes in the liver remains obscure. In this study, PTSD was modeled in sexually mature male Wistar rats using predatory stress induced by a prey’s fear for a predator. Testing in an elevated plus maze allowed the rat population to be divided into animals with low-anxiety (LAP) and high-anxiety (HAP) phenotypes. It was found that morphofunctional analysis of the liver, in contrast to its biochemical profiling, provides a clearer evidence that predatory stress induces liver dysfunction in rats of both phenotypes. This may indicate a decrease in the range of compensatory adaptive reactions in stressed animals. However, in HAP rats, the level of morphofunctional abnormalities in the mechanisms responsible for carbohydrate-fat, water-electrolyte and protein metabolism in the liver testified the prenosological state of the organ, while further functional loading and resulting tension of the regulatory systems could lead to homeostatic downregulation. Meanwhile, the liver of LAP animals was only characterized by insignificant diffuse changes. Thus, we demonstrate here a link between behavioral changes and the degree of morphofunctional transformation of the liver.

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Section: Discussionsupporting

confidence: 55%

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

Kondashevskaya

Artem’eva

Алексанкина

et al. 2022

J Evol Biochem Phys

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“…Initially, the positive correlation between heme oxygenase expression and oxidative damage seems to refute an antioxidant role of heme oxygenase and its products, despite robust support in the mammalian literature (Wang and Chau, 2010;Mishra and Ndisang, 2014;Mancuso et al, 2012). However, the temporal relationships between upregulation of heme oxygenase in the liver, a subsequent increase in circulating biliverdin and a commensurate reduction of oxidative damage in the blood are poorly studied outside of mammals (Butler et al, 2020). Thus, here we may have collected data after heme oxygenase expression increased, but prior to any downstream alterations to antioxidant activity in the plasma.…”

Section: Discussionmentioning

confidence: 99%

“…To quantify glycerol and triglyceride concentration in the plasma, we pipetted 240 μl glycerol reagent (Sigma-Aldrich, F6428) into a clear 96-well plate (Greiner, Sigma-Aldrich) according to Butler et al (2020). We then added 5 μl of each plasma sample in duplicate wells, with water as the control blank and glycerol standard (Sigma-Aldrich, G7793) as the calibrator.…”

Section: Measurement Of Glycerol Triglyceride and Haptoglobinmentioning

confidence: 99%

“…We calculated glycerol and total triglyceride concentration by subtracting absorbance of the blank from the samples and the calibrator, then dividing absorbance of the samples by that of the calibrator. Free triglycerides were calculated by subtracting glycerol from total triglycerides (Butler et al, 2020(Butler et al, , 2016.…”

Section: Measurement Of Glycerol Triglyceride and Haptoglobinmentioning

confidence: 99%

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Low-dose immune challenges result in detectable levels of oxidative damage

Armour

Bruner

Hines

et al. 2020

Journal of Experimental Biology

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Infection can result in substantial costs to animals, so they frequently respond by removing infectious agents with an immune response. However, immune responses entail their own costs, including upregulation of processes that destroy pathogens (e.g. the production of reactive oxygen species) and processes that limit the extent of self-damage during the immune response (e.g. production of anti-inflammatory proteins such as haptoglobin). Here, we simulated bacterial infection across a 1000-fold range using lipopolysaccharide (LPS) administered to northern bobwhite quail (Colinus virginianus), and quantified metrics related to pro-inflammatory conditions [i.e. generation of oxidative damage (d-ROMs), depletion of antioxidant capacity], anti-inflammatory mechanisms (i.e. production of haptoglobin, expression of the enzyme heme oxygenase, production of the organic molecule biliverdin) and nutritional physiology (e.g. circulating triglyceride levels, maintenance of body mass). We detected increases in levels of haptoglobin and d-ROMs even at LPS doses that are 1/1000th the concentration of doses frequently used in ecoimmunological studies, while loss of body mass and decreases in circulating triglycerides manifested only in individuals receiving the highest dose of LPS (1 mg LPS kg −1 body mass), highlighting variation among dosedependent responses. Additionally, individuals that lost body mass during the course of the experiment had lower levels of circulating triglycerides, and those with more oxidative damage had greater levels of heme oxygenase expression, which highlights the complex interplay between pro-and anti-inflammatory processes. Because low doses of LPS may simulate natural infection levels, variation in dose-dependent physiological responses may be particularly important in modeling how free-living animals navigate immune challenges.

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“…HMOX1 is induced by a variety of natural foodstuff including fiber, vitamin B3, and phytochemical classes such as flavonoids, curcuminoids, and terpenes. − Incidentally, HMOX1 can also be induced under starvation or dehydration − though exceptions to this phenomenon have been observed. − Several naturally occurring molecules have been reported as CO sources including keto acids, , amino acids, − pyruvate, glucose, , vanillin, vitamin B9, vitamin C, , cellulose, oxalic acid, phenol, pyrogallol and guaiacol (coffee constituents), , catechol (commonly present in fruits and veggies), protocatechuic acid (e.g., plums, white grapes, olive oil), dihydroxyacetone (glycolysis intermediate), , and flavonoids . While the conditions for liberating CO vary and are nonphysiological in some cases, several of these substrates have been linked to CO production in the microbiota (Figure ).…”

Section: Influence Of Host- and Environment-derived Co On The Gut Mic...mentioning

confidence: 99%

Role of Carbon Monoxide in Host–Gut Microbiome Communication

et al. 2020

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Nature is full of examples of symbiotic relationships. The critical symbiotic relation between host and mutualistic bacteria is attracting increasing attention to the degree that the gut microbiome is proposed by some as a new organ system. The microbiome exerts its systemic effect through a diverse range of metabolites, which include gaseous molecules such as H2, CO2, NH3, CH4, NO, H2S, and CO. In turn, the human host can influence the microbiome through these gaseous molecules as well in a reciprocal manner. Among these gaseous molecules, NO, H2S, and CO occupy a special place because of their widely known physiological functions in the host and their overlap and similarity in both targets and functions. The roles that NO and H2S play have been extensively examined by others. Herein, the roles of CO in host–gut microbiome communication are examined through a discussion of (1) host production and function of CO, (2) available CO donors as research tools, (3) CO production from diet and bacterial sources, (4) effect of CO on bacteria including CO sensing, and (5) gut microbiome production of CO. There is a large amount of literature suggesting the “messenger” role of CO in host–gut microbiome communication. However, much more work is needed to begin achieving a systematic understanding of this issue.

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Effects of stress-induced increases of corticosterone on circulating triglyceride levels, biliverdin concentration, and heme oxygenase expression

Cited by 7 publications

References 75 publications

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

Low-dose immune challenges result in detectable levels of oxidative damage

Role of Carbon Monoxide in Host–Gut Microbiome Communication

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