Effects of storage solutions on in vitro vasoreactivity of radial artery conduits

Chong, W.; Ong, Paul J.L.; Hayward, Christopher; Moat, Neil; Collins, Peter

doi:10.1067/mtc.2001.115921

Cited by 22 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sensitivity of RA to 5-HT was comparable with data obtained by other authors (24,30,34). Reactivity to 5-HT was lower than in the study of Cikirikcioglu et al (30) where authors prepared this blood vessel in other way using a harmonic scalpel.…”

Section: Discussionsupporting

confidence: 71%

Analysis of Vasoreactivity of Isolated Human Radial Artery

et al. 2006

View full text Add to dashboard Cite

Abstract. Radial artery (RA) is increasingly used as graft for coronary artery bypass grafting due to its good long-term patency. However, the mechanism of peri-and post-operative spasm is still unclear. Because of that, the aim of our study is to analyze the contractility of RA and to determine whether the presence of functional endothelium alters its contractile properties. Contractions of isolated RA rings were provoked by exogenously applied vasoconstrictors or by electrical field stimulation (EFS, 20 Hz). The order of vasoconstrictors potency based on their EC 50 values was as follows: angiotensin II > phenylephrine > 5-hydroxytriptamine. Presence of endothelium increased both EC 50 and maximal contraction to phenylephrine and angiotensin II, but inhibited reactivity of RA to 5-hydroxytriptamine. Spontaneous rhythmic contractions (SRC, <4 mHz) and EFS-induced contractions of RA are endothelium-independent and weaker than contractions induced by exogenously applied vasoconstrictors. Our study concludes that RA shows marked sensitivity and reactivity to angiotensin II, phenylephrine, and 5-hydroxytriptamine. Further investigations are necessary to answer why angiotensin II and phenylepehrine induce stronger contractions in the presence of endothelium. In addition, SRC as well as contractions of neurogenic origin may take part in developing vascular spasm of RA.

show abstract

Section: Discussionsupporting

confidence: 71%

Analysis of Vasoreactivity of Isolated Human Radial Artery

et al. 2006

View full text Add to dashboard Cite

show abstract

“…This can be achieved by preserving the vascular endothelial function and/or preventing the enhanced contractile capacity of the arterial smooth muscle. Although graft segments stored in heparinized whole blood had greater endothelium-dependent relaxation to acetylcholine [4], blood-stored radial artery grafts revealed markedly increased smooth muscle contractions [5]. Papaverine, a widely used smooth muscle relaxant in storage solutions, impairs endothelial function [6].…”

Section: Introductionmentioning

confidence: 98%

Biseko® colloidal solution diminishes the vasoreactivity of human isolated radial arteries☆

Szolnoky

Ambrus

Szabó-Biczók

et al. 2009

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

show abstract

“…Heparinized autologous blood seems to be the most suitable solution for storing human arterial grafts and samples, as indicated by both morphological and functional studies [3,9].…”

Section: Introductionmentioning

confidence: 99%

Arterial endothelial denudation by intraluminal use of papaverine–NaCl solution in coronary bypass surgery

Mäyränpää

Simpanen

Hess³

et al. 2004

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

show abstract

Effects of storage solutions on in vitro vasoreactivity of radial artery conduits

Abstract: Heparinized whole blood is a better physiologic medium for preservation of radial artery endothelial and contractile functions during storage before grafting.

Cited by 22 publications

References 0 publications

Analysis of Vasoreactivity of Isolated Human Radial Artery

Analysis of Vasoreactivity of Isolated Human Radial Artery

Biseko® colloidal solution diminishes the vasoreactivity of human isolated radial arteries☆

Arterial endothelial denudation by intraluminal use of papaverine–NaCl solution in coronary bypass surgery

Contact Info

Product

Resources

About