Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging

Pawluski, Jodi L.; Brummelte, Susanne; Barha, Cindy K.; Crozier, Tamara M.; Galea, Liisa A.M.

doi:10.1016/j.yfrne.2009.03.007

Cited by 271 publications

(238 citation statements)

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“…Possible mechanisms for these micro-cellular changes include synaptogenesis, angiogenesis and hypertrophy (Hagemann et al, 2011;Zatorre et al, 2012). Estrogen is known to affect cell proliferation as well as cell survival in the hippocampus in adult female animals (Galea et al, 2006;Pawluski et al, 2009). Hippocampal estrogen receptors have been proposed as one pathway of estrogen effects on neural plasticity (Spencer et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Referring to animal data, different authors suggested reasons why increased hippocampal neurogenesis or spine density could be related to decreased cognitive performance. Worse hippocampal signal to noise ratio due to more highly excitable new neurons is one example (Pawluski et al, 2009;Woolley, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…In further experiments it was documented that not only spine density in the hippocampus increases following rise of estrogen, but that new synapses are built and the sensitivity of the synapses (to NMDA receptor-mediated input) is increased (Woolley et al, 1996(Woolley et al, , 1997. Estrogen effects on the brain are altered by progesterone and might vary between species (Pawluski et al, 2009;Woolley and McEwen, 1993). Following up on these seminal studies, researchers explored estrogen-dependent variations in cognitive function.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal volume and functional connectivity changes during the female menstrual cycle

et al. 2015

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Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during their cycles (early follicular phase, late follicular phase, ovulation and luteal phase). Hormone blood concentrations and cognitive performance in different domains were assessed on each of the measurement occasions. Structural MRI images were processed by means of whole-brain voxel-based morphometry and FreeSurfer. With either method, bilateral increases in hippocampal volume were found in the late follicular phase relative to the early follicular phase. The gray matter probability in regions of hippocampal volume increase was associated with lower mean diffusivity in the same region. In addition, we observed higher functional connectivity between the hippocampi and the bilateral superior parietal lobe in the late follicular phase. We did not find any reliable cycle-related performance variations on the cognitive tasks. The present results show that hormonal fluctuations covary with hippocampal structure and function in the course of the human menstrual cycle.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hippocampal volume and functional connectivity changes during the female menstrual cycle

et al. 2015

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“…Neural stem cells have been reported to fluctuate during the estrous cycle and exogenous estrogen administration is sufficient to increase neural stem cell division 32 . 17β-estradiol, the most potent form of estrogen, can also counteract senescence through p53-antagonizing mechanisms and/or control of telomerase expression 33,34 .…”

Section: Introduction (Epidemiology)mentioning

confidence: 99%

Sexual dimorphism in cancer

et al. 2016

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The incidence of many cancer types is significantly higher in the male than female populations, with associated differences in survival. Occupational and/or behavioral factors are well known underlying determinants. However, cellular/molecular differences between the two sexes are also likely to be important. We are focusing here on the complex interplay that sexual hormones and sex chromosomes can have in intrinsic control of cancer initiating cell populations, tumor microenvironment and systemic determinants of cancer development like the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.3 Introduction (Epidemiology)

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“…For example, a difference between rodents and ungulates is the occurrence of a progesterone peak during pro-oestrus in rodents but not in ungulates. The progesterone peak in rodents occurs after the oestradiol peak and coincides more or less with the preovulatory LH peak (Pawluski et al, 2009). The actions of this preovulatory progesterone peak are essential for the proceptive components of female sexual behaviour in rodents and for amplifying the stimulatory effects of oestradiol on receptivity (reviewed by Levine et al, 2001 andBlaustein, 2008).…”

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confidence: 99%

Central genomic regulation of the expression of oestrous behaviour in dairy cows: a review

Woelders

Lende²,

Kommadath

et al. 2014

Animal

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The expression of oestrous behaviour in Holstein Friesian dairy cows has progressively decreased over the past 50 years. Reduced oestrus expression is one of the factors contributing to the current suboptimal reproductive efficiency in dairy farming. Variation between and within cows in the expression of oestrous behaviour is associated with variation in peripheral blood oestradiol concentrations during oestrus. In addition, there is evidence for a priming role of progesterone for the full display of oestrous behaviour. A higher rate of metabolic clearance of ovarian steroids could be one of the factors leading to lower peripheral blood concentrations of oestradiol and progesterone in high-producing dairy cows. Oestradiol acts on the brain by genomic, non-genomic and growth factor-dependent mechanisms. A firm base of understanding of the ovarian steroid-driven central genomic regulation of female sexual behaviour has been obtained from studies on rodents. These studies have resulted in the definition of five modules of oestradiol-activated genes in the brain, referred to as the GAPPS modules. In a recent series of studies, gene expression in the anterior pituitary and four brain areas (amygdala, hippocampus, dorsal hypothalamus and ventral hypothalamus) in oestrous and luteal phase cows, respectively, has been measured, and the relation with oestrous behaviour of these cows was analysed. These studies identified a number of genes of which the expression was associated with the intensity of oestrous behaviour. These genes could be grouped according to the GAPPS modules, suggesting close similarity of the regulation of oestrous behaviour in cows and female sexual behaviour in rodents. A better understanding of the central genomic regulation of the expression of oestrous behaviour in dairy cows may in due time contribute to improved (genomic) selection strategies for appropriate oestrus expression in high-producing dairy cows.Keywords: sexual behaviour, dairy cow, oestrus, gene expression, brain ImplicationsReduced oestrus expression is one of the factors contributing to the current suboptimal reproductive efficiency in dairy cows. A recent series of publications that correlated the level of oestrous behaviour expression to gene expression levels in the cow brain and anterior pituitary are reviewed here and their findings placed in perspective of what is known about sexual behaviour from studies on other species. The improved understanding of the central genomic regulation of oestrous behaviour expression may in due time contribute to improved (genomic) selection strategies for appropriate oestrus expression in high-producing dairy cows. IntroductionMaintaining good fertility and thereby optimum reproductive performance in dairy cows is of great economic importance for the dairy industry. Artificial insemination of cows is widely practiced in modern dairy farming. To ensure timely insemination and thereby maximize conception rates in the herd and profitability of the farm, it is important that the farmer does not m...

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Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging

Cited by 271 publications

References 178 publications

Hippocampal volume and functional connectivity changes during the female menstrual cycle

Hippocampal volume and functional connectivity changes during the female menstrual cycle

Sexual dimorphism in cancer

Central genomic regulation of the expression of oestrous behaviour in dairy cows: a review

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