Effects of Stellate Ganglion Block on the Peri-operative Vasomotor Cytokine Content and Intrapulmonary Shunt in Patients with Esophagus Cancer

Abstract

Asian Pac J Cancer Prev, 15 (21), 9505-9509 IntroductionOne-lung ventilation (OLV) has been widely applied to cardiothoracic surgery. In spite of unilateral lung ventilation during OLV, bilateral lungs are perfused, which is bound to result in reduced oxygenation, even hypoxemia (Karzai et al., 2009). Hypoxic pulmonary vasoconstriction (HPV) is a phenomenon that the body regulates respiratory and circulatory functions to maintain the oxygen supply within the normal range under the conditions of decreased oxygen partial pressure. The formation mechanism is relatively complicated. Most studies believe that HPV is the direct effect of hypoxia on pulmonary arterial smooth muscle cells and endothelial cells (Evans et al., 2011;Swenson, 2013), but the effect of intrapulmonary During OLV, ET contents were increased significantly in two groups (P<0.05), and no significant difference was presented (P>0.05). NO content in group S was obviously higher than in group N at T3 (P<0.05), whereas CGRP content in group N was markedly lower than in group S at each time point (P<0.05). Qs/Qt was significantly increased in both groups after OLV, but there was no statistical significant regarding the Qs/Qt at each time point between two groups. Conclusions: Total intravenous anesthesia combined with SGB is conducive to regulation of perioperative vasomotor cytokines in thoracotomy, and has little effect on intrapulmonary shunt at the time of OLV.

Regulation of acute reflectory hyperinflammation in viral and other diseases by means of stellate ganglion block. A conceptual view with a focus on Covid-19

“…Another randomized, double blind, placebocontrolled study (Kumar et al, 2014) showed that SGB had a significant analgesic effect on orthopedic upper limb surgery, additionally measured by opioid consumption. García-Morán et al (2013) and Guo et al (2014) demonstrated a favorable effect on perioperative stressrelated cytokine production. Sympathetic hyperactivity is regulated not only peripherally, but also centrally via the hypothalamus (Amino et al, 2007;Taneyama and Goto, 2009), and therefore SGB also improved chronic inflammatory bowel disease (ulcerative colitis), as shown as an additional intervention with sulfasalazine medication.…”

Stellate ganglion ischemia on the prevention of pulmonary vasospasm during bilateral carotid artery ligation: The first experimental study

“…Sympathetic overactivity means high neuron density of STG . STG block reduces pulmonary arterial resistance . STG block prevents lung injury .…”

“…22 STG block reduces pulmonary arterial resistance. 23 STG block prevents lung injury. 24 Bilateral STG block reduces pulmonary capillary wedge pressure.…”

Clinical effect of perioperative stellate ganglion block on mechanical ventilation and respiratory function of elderly patients with septic shock

“…[20] Suppression of the inflammatory response decreases pulmonary vascular resistance and improves blood and air distribution in the lungs, thereby reducing pulmonary hypertension. [21] Second, by suppressing phospholipase A2 expression, the SGB can prevent lung edema and alveolar damage. [22] According to related research, the SGB protects the lungs from injury by reducing the release of surfactant protein A factors Yuan and Chen • Medicine (2024) 103:21 www.md-journal.com when 1 lung is on ventilation.…”