Effects of Statin Treatment on Patients with Angina and Normal or Nearly Normal Angiograms

Manfrini, Olivia; Amaduzzi, Peter Louis; Bergami, Maria; Cenko, Edina

doi:10.15420/ecr.2019.15

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Although there are limitations to interpretation with small numbers, parameters reflecting the epicardial coronary environment, such as FFR and PAV, were related to the achieved LDL-C target goal, and parameters reflecting the microcirculatory environment, such as CFR and IMR, were related to the intensity of atorvastatin ( Supplemental Figure 2 ), and similar trends were observed in another study. 27 …”

Section: Discussionmentioning

confidence: 99%

Effect of Atorvastatin on Serial Changes in Coronary Physiology and Plaque Parameters

Lee

Hwang²,

Kim³

et al. 2022

JACC: Asia

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Section: Discussionmentioning

confidence: 99%

Effect of Atorvastatin on Serial Changes in Coronary Physiology and Plaque Parameters

Lee

Hwang²,

Kim³

et al. 2022

JACC: Asia

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“…While multiple case reports have documented statin use in management, no specific data support this practice. Statin therapy has demonstrated a reduction in angina in patients with non-obstructive coronary artery disease and thus may have a role [ 15 ]. Nonetheless, further studies are needed to establish long-term benefits.…”

Section: Discussionmentioning

confidence: 99%

A Rare Anatomical Variant: Congenital Absence of the Right Coronary Artery with Left Circumflex Artery Supplying the Right Coronary Artery (RCA) Territory

et al. 2021

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Patient: Female, 66-year-old Final Diagnosis: Coronary artery anomalies Symptoms: Chest discomfort • shortness of breath Medication: — Clinical Procedure: Coronary angiography Specialty: Cardiology Objective: Rare disease Background: While most coronary congenital anomalies are uncommon, comprising less than 2% of the general population, a single coronary artery is an especially rare finding within this broader category. It involves a lone vessel forming a single ostium from the aortic trunk. This vessel is then the source through which cardiac blood supply originates. Such congenital coronary artery anomalies are rare but can have clinically relevant consequences such as sudden death and other cardiac complications. Nonetheless, they are usually incidental findings and can be asymptomatic. This report discusses the case of a female patient found to have an absence of the right coronary artery, with the left circumflex supplying the right coronary artery territory. Case Report: We report a rare case of a 66-year-old woman who presented with substernal chest pain and shortness of breath. Vital signs, laboratory work-up, and resting electrocardiogram did not reveal an underlying etiology. However, an exercise stress test was positive. Left heart catheterization was performed and revealed a dominant left circumflex artery supplying the entire right coronary territory. Further imaging revealed the absence of a separate right coronary artery ostium. The patient was treated with a beta-blocker, high-intensity statin, and a nitrate. Conclusions: Single left coronary artery, especially with the absence of the right coronary artery, is particularly rare, but can have significant clinical implications. Prompt diagnosis is important but challenging considering the variable presentation of this condition. It is important to review diagnostic modalities available and the treatment for patients.

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“…CAD is characterised by the deposition of lipids, such as cholesterol, into the arterial wall. This process is known as atherosclerosis and can lead to partial or total occlusion of the vessel, causing cardiac ischemia and potentially leading to a myocardial infarction [2][3][4]. These potentially life-threatening events require urgent medical treatment.…”

Section: Introductionmentioning

confidence: 99%

The Mechanisms of Restenosis and Relevance to Next Generation Stent Design

et al. 2022

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Stents are lifesaving mechanical devices that re-establish essential blood flow to the coronary circulation after significant vessel occlusion due to coronary vessel disease or thrombolytic blockade. Improvements in stent surface engineering over the last 20 years have seen significant reductions in complications arising due to restenosis and thrombosis. However, under certain conditions such as diabetes mellitus (DM), the incidence of stent-mediated complications remains 2–4-fold higher than seen in non-diabetic patients. The stents with the largest market share are designed to target the mechanisms behind neointimal hyperplasia (NIH) through anti-proliferative drugs that prevent the formation of a neointima by halting the cell cycle of vascular smooth muscle cells (VSMCs). Thrombosis is treated through dual anti-platelet therapy (DAPT), which is the continual use of aspirin and a P2Y12 inhibitor for 6–12 months. While the most common stents currently in use are reasonably effective at treating these complications, there is still significant room for improvement. Recently, inflammation and redox stress have been identified as major contributing factors that increase the risk of stent-related complications following percutaneous coronary intervention (PCI). The aim of this review is to examine the mechanisms behind inflammation and redox stress through the lens of PCI and its complications and to establish whether tailored targeting of these key mechanistic pathways offers improved outcomes for patients, particularly those where stent placement remains vulnerable to complications. In summary, our review highlights the most recent and promising research being undertaken in understanding the mechanisms of redox biology and inflammation in the context of stent design. We emphasize the benefits of a targeted mechanistic approach to decrease all-cause mortality, even in patients with diabetes.

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Effects of Statin Treatment on Patients with Angina and Normal or Nearly Normal Angiograms

Abstract: This article offers an updated and comprehensive overview of major findings on the effects of statin treatment in patients with chronic angina but without any epicardial coronary artery with obstructive lesion.

Cited by 3 publications

References 33 publications

Effect of Atorvastatin on Serial Changes in Coronary Physiology and Plaque Parameters

Effect of Atorvastatin on Serial Changes in Coronary Physiology and Plaque Parameters

A Rare Anatomical Variant: Congenital Absence of the Right Coronary Artery with Left Circumflex Artery Supplying the Right Coronary Artery (RCA) Territory

The Mechanisms of Restenosis and Relevance to Next Generation Stent Design

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