Effects of standardized quassinoid-rich Eurycoma longifolia extract in a rat model of osteoporosis due to testosterone deficiency: A densitometric, morphometric and biomechanical study

Abstract

Quassinoid-rich EL extract enables to protect against bone loss due to testosterone deficiency. The protective effect on cortical thickness and biomechanical parameters is comparable to testosterone group.

Effect of herbal extract Eurycoma longifolia (Physta®) on female reproductive hormones and bone biochemical markers: an ovariectomised rat model study

“…The action cause reduced intestinal calcium absorption and may contribute towards a lower level of calcium in blood serum. A pre-clinical study on rats supports the positive effects of TA on bone turnover in androgendeficient rats [40], as TA supplementation reduced the percentage of osteoclasts and increased the percentage of osteoblasts on the bone surface [40]. The measurement of BALP activity can be used as a marker of bone formation and bone resorption in vivo [34,41].…”

Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study

“…The reduction in NTX level cannot be assumed to be clinically insignificant since a similar reduction was achieved in postmenopausal women in a 6-week smoking cessation programme (37). Both E. longifolia and L. pumila have demonstrated a protective effect on bone loss due to the osteoporosis in previously published studies (37)(38)(39)(40)(41). A pre-clinical study on rats supports the positive effects of E. longifolia on bone turnover in androgen-deficient rats, based on the study quassinoid-rich E. longifolia extract enables to protect against bone loss due to testosterone deficiency (38) The proandrogen properties of E. longifolia stimulated osteoblast proliferation and differentiation, resulting in increased bone formation rate.…”

“…Both E. longifolia and L. pumila have demonstrated a protective effect on bone loss due to the osteoporosis in previously published studies ( 37 – 41 ). A pre-clinical study on rats supports the positive effects of E. longifolia on bone turnover in androgen-deficient rats, based on the study quassinoid-rich E. longifolia extract enables to protect against bone loss due to testosterone deficiency ( 38 ) The proandrogen properties of E. longifolia stimulated osteoblast proliferation and differentiation, resulting in increased bone formation rate. E. longifolia also contains high concentrations of superoxide dismutase, an antioxidant that plays an important role in reducing bone loss and maintaining bone formation rate ( 39 ).…”

The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males

“…While our findings concur with previous studies that EL increases testosterone levels, it is plausible that the increase of testosterone could be due to direct stimulation of the adrenal gland in the HPA axis (Talbott et al., 2006) to produce testosterone precursors such as dehydroepiandrosterone, dehydroepiandrosterone sulphate, androstenedione, androstenediol and 11β‐hydroxyandrostenedione (11βOHA4) (Rege et al., 2013). These precursors could then be converted to more potent androgens such as testosterone and oestrogens (Kaufman et al., 1990; Luu‐The, 2013; Pelletier, 2008; Rosenfield, 2005) by plant compounds such as flavonoids (Azarneoshan et al., 2009), phenolic (Khanam et al., 2014) and quassinoids (Jayusman et al., 2018; Low, Choi, et al., 2013; Rahman et al., 2017). EL is known to have active flavonoids (Bashir et al., 2017; Khanam et al., 2014) and quassinoids (Darise et al., 1982; Miyake et al., 2009; Tung et al., 2017), which could potentially increase testosterone levels via the HPG and as well via the HPA axis by converting the testosterone precursors.…”