Effects of standardized Ginkgo biloba extract on the acquisition, retrieval and extinction of conditioned suppression: Evidence that short-term memory and long-term memory are differentially modulated

Zamberlam, Cláudia Raquel; Vendrasco, N.C.; Oliveira, Daniela R. de; Gaiardo, Renan Barretta; Cerutti, Suzete Maria

doi:10.1016/j.physbeh.2016.06.036

Cited by 16 publications

(21 citation statements)

References 130 publications

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“…More recently we showed that EGb-treatment, in a dose-dependent manner, modulates short-and long-term fear memory during its acquisition and extinction on CLS task, suggesting that different neurochemical systems can be involved in the acquisition and retrieval of fear memory. Further, the reduced fear expression during retrieval might be related to an anti-anxiety effect rather than to mnemonic effects, as previously hypothesized by us [6].…”

Section: Introductionsupporting

confidence: 60%

“…Our data has established that the treatment with flavonoidrich plants or flavonoidic molecules resulted in a significant retention of long-term fear memory and its spontaneous recovery evaluated during extinction test sessions, although FfB did not prevent the acquisition of the extinction of fear conditioning within-sessions [6,9]. Moreover, our data showed, through pharmacological manipulation and genetic analysis, that acquisition of lick suppression is mediated by hydroxytryptamine (serotonin) receptor, subunit 1A (5-HT 1A R), gamma-aminobutyric acid type A receptor (GABA A R) and GluN2B-NMDAR in the dorsal hippocampal formation (dHF).…”

Section: Flavonoidic Fraction Improves the Acquisition Of Fear Memorymentioning

confidence: 62%

“…Converging evidence over the last few decades has shown that extracts of flavonoid-rich plant or flavonoid molecules have been the focus of research as modulators of brain function, neuroprotective, chemopreventive and anti-anxiety properties and memory-enhancing effects [1][2][3][4][5][6]. It has been suggested that the ability to modulate the glutamatergic, serotoninergic, and GABAergic neurotransmission is attributable to flavonoidinduced effects.…”

Section: Introductionmentioning

confidence: 99%

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Protective, Preventive and Enhancing-Memory Effects of the Flavonoidic-Rich Plants or Flavonoidic Molecules: Behavioural, Neurochemical and Pharmacological Correlates

Cerutti¹

2017

IJCAM

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Our group has focused on understanding the putative neuromodulatory effects of flavonoidic-rich plants or flavonoidic molecules. This mini-review summarizes the effects of these substances on fear memory and anxiety in adult and middle-aged rats Multiple-dosing schemes, different behavioral procedures and different time points of treatment have provided direct evidence of the modulatory effects of these molecules upon the acquisition and extinction of conditioned suppression. This has enabled us to further evaluate short-and longterm memory. To better understand the effects of standardized extract of Ginkgo biloba (EGb) or of Flavonoidic fraction (FfB) on fear memory, we conducted both pharmacological and molecular analysis. The dose-dependent effects observed after EGb or FfB treatments on the conditioned fear include the spontaneous recovery of fear memory. FfB reversed the effect of blocking of GluN2B subunits of N-methyl-D-Aspartate receptor (GluN2B-NMDARs) on conditioned suppression. These results turned our attention to the therapeutic relevance of these data, as the pharmacological agents that enhance the acquisition/consolidation of fear memory or fear extinction might serve as an adjunct to the treatment of memory decline or anxiety disorders. In addition, the molecular results provided important information regarding the role of the dorsal hippocampal formation (dHF) on conditioned suppression and as a possible target to potential drug therapy. Additionally, we evaluated the effects of EGb on short and long term-memory in middle-aged rats submitted to the plus maze discriminative avoidance task (PM-DAT) as well as upon the level of DNA damage of Prefrontal cortex (PFC) and dHF. All together, these findings appear to support and extend the view that flavonoids are cognitive enhancers.

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Section: Introductionsupporting

confidence: 60%

Section: Flavonoidic Fraction Improves the Acquisition Of Fear Memorymentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Protective, Preventive and Enhancing-Memory Effects of the Flavonoidic-Rich Plants or Flavonoidic Molecules: Behavioural, Neurochemical and Pharmacological Correlates

Cerutti¹

2017

IJCAM

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“… 166 Ginko biloba has also exhibited nootropic effects. 167 , 168 Myriad number of phytochemicals present in fruits, vegetables, herbs etc have been demonstrated to have a wide range of biological activities that are responsible for their medicinal properties. 169 , 170 …”

Section: Growing Prospects Of Botanicalsmentioning

confidence: 99%

Integration of botanicals in contemporary medicine: road blocks, checkpoints and go-ahead signals

Chugh

Bali

Koul

2018

Integrative Medicine Research

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The use of botanicals for maintaining good health and preventing diseases is undisputed. The claimed health benefits of natural health products and herbal medicines are based on traditional claims, positive results obtained in preclinical studies and early phase clinical trials that are not backed by safety and efficacy evidences approved by regulatory agencies. Although, the popularity of botanicals is growing, health care practitioners of modern medicine seldom recommend their use because of ill equipped database of their safety and potency. This review discusses problems that preclude botanicals from integrating into the mainstream contemporary therapeutics and cues that provide impetus for their realisation.

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“…In relation to the diet, flavonoids have been described as promising plant-based bioactives capable of modulating different aspects of neuroplasticity, resulting in improvements in memory in both rodents [2] and humans [3,4]. For example, flavonoids have been correlated with their ability to modulate the phosphorylation state of intracellular proteins by the activation or inhibition of phosphoinositide 3-kinase (PI3K), protein kinase C (PKC), mitogenactivated protein kinase (MAP), CAMP responsive element binding protein 1 (CREB-1), growth associated protein 43 (GAP-43), brain-derived neurotrophic factor (BDNF), or to alter expression of N-methyl d-aspartic acid (NMDA) receptors (NMDARs), GABA A receptors (GABA A Rs), and 5-HT receptors (5-HTRs) [5,6]. In addition, flavonoids can modulate epigenetic modifications [7].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids as Modulators of Synaptic Plasticity: Implications for the Development of Novel Therapeutic Strategies for Healthy Lifestyle

Carbonel¹,

Cecyn²,

Girão³

et al. 2020

Flavonoids - A Coloring Model for Cheering Up Life

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Flavonoids are potential group of phytochemicals found in normal diets capable of mediating improvements in cognition and may reverse age-related declines in memory. Aging is associated with alteration of hippocampal synaptic plasticity and contribute to decline in cognitive functions. The current studies are directed at a greater understanding of how and why the brain modifies synaptic strength with dietary-derived phytochemicals (flavonoids) and age-related declines in cognitive functions (such as learning and memory). Flavonoids modulate neuronal function and thereby influence cognition. In addition, it has been suggested that flavonoids may delay the development of Alzheimer's diseaselike pathology, anxiety, and depression disorders, suggesting a novel therapeutic strategy. Emerging evidence suggest that flavonoids are modulators of signaling pathways critical for controlling synaptic plasticity in the brain. For example, phosphatidylinositol-3 kinase (PI3K)/Akt, mitogen-activated protein kinase, protein kinase C, pathways could be involved Ca 2+ signaling. Significants questions such as: (i) How does flavonoids affect plasticity? (ii) What receptors are modulating by flavonoids and how are they regulated? (iii) Do flavonoids have a neuroprotective effect in aging? are asked.

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Effects of standardized Ginkgo biloba extract on the acquisition, retrieval and extinction of conditioned suppression: Evidence that short-term memory and long-term memory are differentially modulated

Cited by 16 publications

References 130 publications

Protective, Preventive and Enhancing-Memory Effects of the Flavonoidic-Rich Plants or Flavonoidic Molecules: Behavioural, Neurochemical and Pharmacological Correlates

Protective, Preventive and Enhancing-Memory Effects of the Flavonoidic-Rich Plants or Flavonoidic Molecules: Behavioural, Neurochemical and Pharmacological Correlates

Integration of botanicals in contemporary medicine: road blocks, checkpoints and go-ahead signals

Flavonoids as Modulators of Synaptic Plasticity: Implications for the Development of Novel Therapeutic Strategies for Healthy Lifestyle

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