Effects of standardized extracts GK501, from <i>Ginkgo biloba</i> L., G115 from <i>Panax ginseng</i> C. A. Meyer, and their combination, gincosan® (PHL‐00701), on the brain levels of biogenic monoamines and on the serum content of prolactin, growth hormone and ACTH

Hadjiivanova, Ch.; Petkov, V.; Milanov, S; Visheva, N; Boyadjieva, Nadka

doi:10.1002/ptr.2650070209

Cited by 17 publications

(12 citation statements)

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“…The reported augmentation of 5HT, 5HIAA by EGb 761 (Morier-Teissier et al 1987;Petkov et al 1993) and our observed attenuation of 5HT and 5HIAA levels, and augmentation of NA, DA and their metabolites in various regions of the rat brain, by IGb containing GAC (unpuriÞed extracts) , would seem to reßect, respectively, the anxiogenic-like and anxiolytic manifestation in the animal recipients. The reversible MAO A and MAO B inhibitory activity of the low molecular weight entities from the dried or fresh leaves of Ginkgo biloba has been reported (White et al 1996).…”

Section: Discussionmentioning

confidence: 46%

Anxiolytic activity of ginkgolic acid conjugates from Indian Ginkgo biloba

Satyan

Jaiswal

Ghosal³

et al. 1998

Psychopharmacology

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Ginkgolic acid conjugates (GAC) (6-alkylsalicylates, namely n-tridecyl-, n-pentadecyl-, n-heptadecyl-, n-pentadecenyl- and n-heptadecenylsalicylates) isolated from the leaves of Indian Ginkgo biloba Linn., (IGb) were tested for their putative role in anxiety in rats. Elevated plus maze, open-field behaviour, novelty-induced feeding latency and social interaction were the rodent behavioural models used in this study. GAC (0.3 and 0.6 mg/kg, each, p.o.) on single acute administration, showed dose-related changes in the behaviour. GAC (0.6 mg/kg) and DZ augmented open arm entries, the open arm/closed arm entries ratio and increased time spent in the open arm on the elevated plus maze. In the open field, GAC (0.6 mg/kg) and DZ significantly increased ambulation and reduced the immobility time. EGb 761 showed a similar profile. GAC (0.6 mg/kg) and DZ significantly attenuated the increased latency to feed in novel environment. By contrast, EGb 761 and Ginkocer further augmented feeding latency. None of the drugs tested showed any significant effect in the social interaction test. GAC showed consistent and significant anxiolytic activity in all the variables investigated. By contrast, EGb 761 and Ginkocer, which are devoid of GAC, did not evoke significant activity. However, increased rearing and decreased immobility time only in open field behaviour shown by EGb 761 may be due to some antianxiety activity of a lesser degree. Our observations suggest that GAC may be the active constituents of Ginkgo biloba responsible for the anxiolytic activity.

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Section: Discussionmentioning

confidence: 46%

Anxiolytic activity of ginkgolic acid conjugates from Indian Ginkgo biloba

Satyan

Jaiswal

Ghosal³

et al. 1998

Psychopharmacology

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“…Such specific activity has not been reported in other crude drugs such as Ginkgo biloba L. or Panax ginseng C.A. Meyer (Petkov and Staneva, 1963;Petkov et al, 1993).…”

Section: Discussionmentioning

confidence: 91%

Acanthopanax senticosus Harms as a prophylactic for MPTP-induced Parkinson's disease in rats

Fujikawa

Miguchi

Kanada

et al. 2005

Journal of Ethnopharmacology

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“…Meyer, which also act as regulators in the stress response system (Petkov and Staneva, 1963;Petkov et al, 1993), appear to have a non-specific effect on the DA and NA levels in the striatum and hypothalamus of old rats. Thus, our results suggest that ASH extract may have a different mechanism of action to other analeptics, by preferentially stimulating the striatum and hypothalamus to cope with stress.…”

Section: Discussionmentioning

confidence: 96%

Effect of Acanthopanax senticosus Harms on biogenic monoamine levels in the rat brain

Fujikawa

Soya²,

Hibasami

et al. 2002

Phytotherapy Research

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The extract of the stem bark of Acanthopanax senticosus Harms (ASH) is known to have healing and protective effects on stress-induced disturbance of mental status. We have analysed whether a single or chronic (2 week) administration of ASH can affect concentrations of noradrenaline (NA), dopamine (DA) and their metabolites in the normal rat brain. A single p.o. administration of ASH elevated the NA and DA levels in the whole brain of rats in a dose-dependent manner. A single or 2 week administration of ASH (500 mg/kg) showed a marked increase in the DA level only in the striatum. However, NA levels were increased by a single dose of ASH in a wide range of brain regions such as the cortex, hypothalamus, striatum, hippocampus, substantia nigra and pons. When administered for 2 weeks no increase in NA levels was seen in these brain regions, except for an increase in the frontal cortex and anterior hypothalamus. The present results suggest that ASH may act by regulating NA and DA levels in specific brain regions related to stress response and Parkinson's disease.

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Effects of standardized extracts GK501, from Ginkgo biloba L., G115 from Panax ginseng C. A. Meyer, and their combination, gincosan® (PHL‐00701), on the brain levels of biogenic monoamines and on the serum content of prolactin, growth hormone and ACTH

Cited by 17 publications

References 10 publications

Anxiolytic activity of ginkgolic acid conjugates from Indian Ginkgo biloba

Anxiolytic activity of ginkgolic acid conjugates from Indian Ginkgo biloba

Acanthopanax senticosus Harms as a prophylactic for MPTP-induced Parkinson's disease in rats

Effect of Acanthopanax senticosus Harms on biogenic monoamine levels in the rat brain

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