Abstract:Glutamate is one of the major excitatory neurotransmitters in the central nervous system. Increasing glutamate leads to neurodegenerative disease. Nowadays, plant medicine plays a role in the treatment of some disorders. In this research, we investigated the neuroprotective effect of Ferula gummosa root extract against glutamate-induced oxidative stress in the rat adrenal pheochromocytoma (PC12) and mouse neuroblastoma (N2a) cell lines. The cells were pretreated with extract for 2 h and then exposed … Show more
“…Malondialdehyde production, a marker of lipid peroxidation, was measured based on thiobarbituric acid‐reactive substances, as previously described (Hamid Reza Sadeghnia et al, 2017 ). At the end of treatments, a cell lysate was prepared by scraping the cell monolayers with trichloroacetic solution (1 ml, 2.5%).…”
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
“…Malondialdehyde production, a marker of lipid peroxidation, was measured based on thiobarbituric acid‐reactive substances, as previously described (Hamid Reza Sadeghnia et al, 2017 ). At the end of treatments, a cell lysate was prepared by scraping the cell monolayers with trichloroacetic solution (1 ml, 2.5%).…”
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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