Effects of splenohepatopexy and omentopexy in experimentally induced infrahepatic portal hypertension in rats

Abstract

The purpose of this study was to determine whether splenohepatopexy (SHP) or omental transposition (OP) could reverse the portal hypertension (PH) induced by portal vein ligation (PVL). Fifty-eight Wistar rats divided into four groups: in group A (22 rats) PH was produced by calibrated PVL. In group B (8 rats), SHP was performed. Group C animals (13 rats) underwent SHP and PVL. In group D (15 rats) both PVL and OP were done. In all of the rats, the portal pressures (PP) were measured before and after the production of PVL. For SHP, small areas on the spleen and liver capsula were stripped off, and these two areas were placed together. In group D, an omentum patch was tied on the prepared liver surface. Twelve weeks after surgery, the PP were measured again and portal angiography was done. The liver, omentum and spleen were histopathologically examined. In all of the groups, the PP after PVL were significantly higher than before PVL. Twelve weeks after surgery, the PP of SHP and OP groups were significantly lower than those with PVL alone. Angiographic study showed many collaterals between transposed tissue and liver. Histopathologically, the collaterals of animals with SHP or OP were found to be well developed to allow sufficient flow for PP reduction. Both SHP and OP may reverse the increased PP in PVL model of PH. In the future; these methods may be alternative techniques for PP reduction in human beings as well.

Omentum Transposition as a Solution for Bronchopleural Fistula and Empyema

“…Jiang et al investigated the patients with non-small cell lung cancer who underwent surgical treatment for BPF with omental flap after pulmonary resection. They found that the median postoperative hospital stay to repair was the BPF 15 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) days [25]. There were no complications related to the omentoplasty procedure, similar to our study.…”

“…Among these approaches, the omentum transposition into the thoracic cavity to treat BPF is a method that has been used for a long time. There are a limited number of studies about omentopexy in the literature [16][17][18][19]. Many studies emphasize the success of using this method in patients with post-resectional BPF [13].…”

Stability of a rat model of prehepatic portal hypertension caused by partial ligation of the portal vein

“…In our experiment, the PVP value before ligation and in control animals was within the same range as that found by other investigators [4,6,7] . The establishment of a partial PVL resulted in instant congestion in the portal vein system, and the PVP immediately increased to 25-30 cmH2O.…”