Effects of Spinal Cord Stimulation in Patients with Chronic Nausea, Vomiting, and Refractory Abdominal Pain

Kapural, Leonardo; Brown, Bradbury Kenneth; Harandi, Shervin; Rejeski, Jared; Koch, Kenneth L.

doi:10.1007/s10620-021-06896-5

Cited by 9 publications

(4 citation statements)

References 21 publications

(38 reference statements)

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“…On implantation of the SCS, the patient reported a reduction in diarrheal episodes and associated abdominal pain. [ 13 ] Another recent study assessing the effect of SCS in patients with chronic nausea, vomiting, and refractory abdominal pain saw patients reporting reduced abdominal pain scores after SCS,[ 12 ] supporting the findings of the aforementioned case report.…”

Section: Discussionsupporting

confidence: 65%

Spinal cord stimulation-induced gastroparesis: A case report

Manjunath,

Goel,

Baskaran

et al. 2023

Surgical Neurology International

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Background: Spinal cord stimulation (SCS) involves the utilization of an implantable neurostimulation device, stereotypically used in the treatment of patients with chronic neuropathic pain. While these devices have been shown to have significant clinical benefits, there have also been documented potential complications, including the risk of infection, fractured electrodes, electrode migration, and lack of symptom improvement. In addition, there has been minimal documentation on gastrointestinal (GI) side effects after SCS implantation. Case Description: A 42-year-old patient with chronic axial and radicular neuropathic pain in her back and left leg status post multiple lumbar surgeries underwent implantation of an open paddle lead in the T8–T9 region. After the procedure, the patient endorsed a 50% decrease in pain at the 6-week follow-up with no further concerns. However, at the 18 months follow-up, the patient endorsed severe constipation when the SCS was turned on, leading to subsequent evaluation by gastroenterology, motility studies, and a thorough bowel regimen. Symptoms persisted, and the patient ultimately opted for the removal of the SCS implant at 21 months after the initial surgery. Conclusion: While the exact mechanism behind the GI side effects endorsed in this patient is unknown, current literature postulates a variety of theories, including a SCS-induced parasympathetic blockade of the GI tract. Further, investigation is needed to determine the exact effects of SCS on the GI tract.

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Section: Discussionsupporting

confidence: 65%

Spinal cord stimulation-induced gastroparesis: A case report

Manjunath,

Goel,

Baskaran

et al. 2023

Surgical Neurology International

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“…Table 7 shows efficacy of several bioelectric treatments including vagal nerve stimulation, spinal cord stimulation, and GES (116–141). A recent randomized, crossover trial of ON vs OFF GES in patients with medically refractory vomiting with or without delayed GE, GES decreased the vomiting frequency.…”

Section: Management Of Gpmentioning

confidence: 99%

ACG Clinical Guideline: Gastroparesis

et al. 2022

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Gastroparesis is characterized by symptoms suggesting retention of food in the stomach with objective evidence of delayed gastric emptying in the absence of mechanical obstruction in the gastric outflow. This condition is increasingly encountered in clinical practice. These guidelines summarize perspectives on the risk factors, diagnosis, and management of gastroparesis in adults (including dietary, pharmacological, device, and interventions directed at the pylorus), and they represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation process. When the evidence was not appropriate for Grading of Recommendations, Assessment, Development, and Evaluation, we used expert consensus to develop key concept statements. These guidelines should be considered as preferred but are not the only approaches to these conditions.

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“…[19][20][21] SCS has also been reported to suppress abdominal pain in patients with gastric disorders and chronic pancreatitis. [22,23] Direct gastrointestinal electrical stimulation Direct electrical stimulation of the gastrointestinal tract is accomplished by chronically implanting stimulation electrodes at the serosal surface of the esophagus, stomach, small intestine and colon. [24] Major variations in gastrointestinal electrical stimulation are in configuration of stimulation parameters, including long pulse stimulation, short pulse stimulation and pulse train stimulation.…”

Section: Vagal Nerve Stimulationmentioning

confidence: 99%

Neuromodulation for functional upper gastrointestinal diseases

Chen

2023

Gut Microb Integr Wellness

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Neuromodulation has recently received a great deal of attention among academic institutions, government funding agents and industries. This mini-review focuses on methods and applications as well as mechanisms of various neuromodulation methods in treating functional diseases of the upper gastrointestinal tract. First, the methods of various neuromodulation are introduced, including direct electrical stimulation at various peripheral nerves, such as the vagus nerve, sacral nerve and spinal cord, direct gastrointestinal electrical stimulation and noninvasive/transcutaneous electrical stimulation. Then, literature search was performed on the clinical applications of these neuromodulation methods for treating gastroesophageal reflux disease, functional dyspepsia and gastroparesis. Due to nature of the mini-review, the search results are selectively presented based on the expert opinions. Finally, a perspective is provided based on the author’s own experience in this field of research.

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Effects of Spinal Cord Stimulation in Patients with Chronic Nausea, Vomiting, and Refractory Abdominal Pain

Cited by 9 publications

References 21 publications

Spinal cord stimulation-induced gastroparesis: A case report

Spinal cord stimulation-induced gastroparesis: A case report

ACG Clinical Guideline: Gastroparesis

Neuromodulation for functional upper gastrointestinal diseases

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