Effects of spermine on the morphology, digestive enzyme activities, and antioxidant status of jejunum in suckling rats

Cao, Wei; Liu, Guangmang; Fang, Tingting; Wu, Xianjian; Jia, Gang; Zhao, Hua; Chen, Xiaoling; Wu, Caimei; Wang, Jing; Cai, Jingyi

doi:10.1039/c5ra15793e

Cited by 40 publications

(50 citation statements)

References 45 publications

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“…COS ingestion significantly increased the representative enzymatic antioxidant activities (SOD and CAT) in the present study, suggesting that COS ingestion can partly enhance the function of antioxidant defence systems by improving enzymatic antioxidant activity25. A recent study reported that GSH and T-AOC are regarded as participants in non-enzymatic antioxidant defence systems26. Here, we found that dietary COS supplementation significantly elevated amniotic fluid T-AOC activity.…”

Section: Discussionsupporting

confidence: 70%

Amniotic fluid metabolomics and biochemistry analysis provides novel insights into the diet-regulated foetal growth in a pig model

Wan

Jiang

Zhang

et al. 2017

Sci Rep

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Foetal loss and intrauterine growth restriction are major problems in mammals, but there are few effective ways in preventing it. Intriguingly, chitosan oligosaccharide (COS), a biomaterial derived from chitosan, can promote foetal survival and growth. Therefore, we have investigated how COS affects foetal survival and growth in a pig model. Fifty-two sows were divided into two treatment groups (n = 26) and fed either solely a control diet or a control diet that includes 100 mg/kg COS. Amniotic fluid and foetus samples from six sows that were of average body weight in each group were collected on gestation day 35. We applied a 1H NMR-based metabolomics approach combined with biochemistry analysis to track the changes that occurred in the amniotic fluid of pregnant sows after COS intervention. Maternal COS inclusion had enhanced (P < 0.05) the foetal survival rate and size at 35 days. COS supplementation had both increased (P < 0.05) SOD, CAT and T-AOC activities and elevated (P < 0.05) IL-10, IgG and IgM concentrations in the amniotic fluid. Moreover, COS had affected (P < 0.05) the amniotic fluid’s lysine, citrate, glucose and hypoxanthine levels. Overall, COS inclusion induced amniotic fluid antioxidant status and metabolic profiles modifications characterising improvements in foetal survival and growth in a pig model.

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Section: Discussionsupporting

confidence: 70%

Amniotic fluid metabolomics and biochemistry analysis provides novel insights into the diet-regulated foetal growth in a pig model

Wan

Jiang

Zhang

et al. 2017

Sci Rep

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“…In juvenile Jian carp, trypsin and lipase activities in intestine significantly increased with higher levels of dietary arginine (Chen et al, ). Arginine metabolites, such as NO and polyamines, might involve in the beneficial effects on digestive and absorptive enzyme activities (Cao et al, ; DiMagno, Hao, Tsunoda, Williams, & Owyang, ).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of N‐carbamylglutamate and effects on growth, intestinal enzyme activities, immunological and antioxidant abilities of juvenile yellow catfish (Pelteobagrus fulvidraco)

et al. 2019

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The effects of N‐carbamylglutamate (NCG) on growth, intestinal enzyme activities, immunological and antioxidant parameters were evaluated by a 56‐d feeding trial in Pelteobagrus fulvidraco fed diets containing NCG with 0, 250, 500, 1,000 or 2,000 mg/kg, respectively. The results showed that 250 mg/kg of NCG resulted in significantly higher weight gain, intestine fold height, intestine lipase, serum lysozyme, glutathione peroxidase and total antioxidant capacity than control (p < 0.05). However, higher intestine trypsin, arginase, arginine decarboxylase, ornithine decarboxylase, diamine oxidase activities and serum nitric oxide content were observed in 500 mg/kg NCG group compared to control or 2,000 mg/kg (p < 0.05). The survival rate, intestine muscular layer thickness, serum lysozyme and superoxide dismutase activities in 2,000 mg/kg NCG group were significantly lower than those in control and 250 mg/kg group, accompanied by the higher feed conversion ratio in the same group (p < 0.05). Together, dietary NCG level at 250 or 500 mg/kg improved growth, intestinal enzyme activities, immunological and antioxidant abilities, while high NCG level of 2,000 mg/kg had a negative effect. Quadratic regression analysis on weigh growth, diamine oxidase and lysozyme activities indicated that the recommended optimum dietary NCG level was 213.48–314.50 mg/kg of the dry diet.

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“…It was confirmed that exorbitant dose of spermine have numerous side effects, such as reduced microbe, tumors development, growth decrease and even cell death (Cipolla et al, 2010). On the other hand, spermine at the appropriate dose can exert beneficial effects, including intestinal growth promotion and the antioxidant capacity improvement (Cao et al, 2015).…”

Section: Discussionmentioning

confidence: 84%

“…Spermine-induced effects in guts can be associated with morphological and physiological alterations, such as weight and length enhancement, villus increase, crypt depth decrease, enzymes activities enhancement/decrease and macromolecular metabolism improvement (Cao et al, 2015;Liu et al, 2015;Fang et al, 2016). Moreover, spermine was reported to be a free radical scavenger, so it can protect mammalian cells from reactive oxygen species (ROS) in vitro (Ha et al, 1998) and improve the antioxidant capacity of the suckling animals serum or duodenum (Cao et al, 2015;Fang et al, 2016). However, there is no information about the relationship between spermine and the antioxidant capacity of weaned animal liver and spleen in vivo.…”

Section: Introductionmentioning

confidence: 99%

Effect of spermine on liver and spleen antioxidant status in weaned rats

et al. 2016

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Effects of spermine on the morphology, digestive enzyme activities, and antioxidant status of jejunum in suckling rats

Abstract: Spermine is a ubiquitous cellular component that plays vital roles in the maintenance of nucleic acids, regulation of kinase activities, protein synthesis, control of ion channel activities and renewal of the gut epithelium.

Cited by 40 publications

References 45 publications

Amniotic fluid metabolomics and biochemistry analysis provides novel insights into the diet-regulated foetal growth in a pig model

Amniotic fluid metabolomics and biochemistry analysis provides novel insights into the diet-regulated foetal growth in a pig model

Dietary supplementation of N‐carbamylglutamate and effects on growth, intestinal enzyme activities, immunological and antioxidant abilities of juvenile yellow catfish (Pelteobagrus fulvidraco)

Effect of spermine on liver and spleen antioxidant status in weaned rats

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