Effects of Specific Foods and Dietary Components on Drug Metabolism

Anderson, Karl E.

doi:10.1007/978-1-60327-362-6_9

Cited by 3 publications

(2 citation statements)

References 147 publications

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“…In vitro and in vivo studies help to tease apart possible mechanisms of these interactions. Dietary proteins as well as protein supplements have been known to increase drug metabolism (85). Protein sources (eg, soy protein isolate, casein) may have differential effects on drug disposition through induction of enzymes and transporters (86).…”

Section: Specific Foods or Food Components Specific Foods Canmentioning

confidence: 99%

Drug–Nutrient Interactions: A Broad View with Implications for Practice

Boullata¹,

Hudson²

2012

Journal of the Academy of Nutrition and Dietetics

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Section: Specific Foods or Food Components Specific Foods Canmentioning

confidence: 99%

Drug–Nutrient Interactions: A Broad View with Implications for Practice

Boullata¹,

Hudson²

2012

Journal of the Academy of Nutrition and Dietetics

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“…The CYP system plays an important role in the metabolism/biotransformation of drugs and xenobiotics (as for detoxification), and they are therefore one of the most important factors contributing to DIs, including food–drug interactions [ 12 ]. In short, the CYP system is a large family of hemoproteins that catalyze a wide range of reactions (hydroxylation, epoxidation, oxygenation, dealkylation, isomerization, desaturation, reduction, etc.).…”

Section: Importance Of Cytochrome P450 Enzymes and Drug Transportementioning

confidence: 99%

Food–Drug Interactions with Fruit Juices

Petrić

Žuntar

Putnik

et al. 2020

Foods

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Fruit juices contain a large number of phytochemicals that, in combination with certain drugs, can cause food–drug interactions that can be clinically significant and lead to adverse events. The mechanisms behind such interactions are in most cases related to phytochemical interference with the activity of cytochrome P450 metabolizing enzymes (CYPs) or drug transporters. Moreover, alterations in their activity can have a clinical relevance if systemic exposure to the drug is decreased or increased, meaning that the pharmacological drug effects are suboptimal, or the drug will cause toxicity. In general, the common pharmacokinetic parameters found to be altered in food–drug interactions regarding fruit juices are the area under the concentration–time curve, bioavailability, and maximum plasma concentration. In most cases, the results from the drug interaction studies with fruit juices provide only limited information due to the small number of subjects, which are also healthy volunteers. Moreover, drug interactions with fruit juices are challenging to predict due to the unknown amounts of the specific phytochemicals responsible for the interaction, as well as due to the inter-individual variability of drug metabolism, among others. Therefore, this work aims to raise awareness about possible pharmacological interactions with fruit juices.

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Introductory Chapter: Pharmacokinetics and Drug Metabolism with Special Reference to Herbal Formulations

Sharma,

Siwan,

Rudrapal

2024

Drug Metabolism and Pharmacokinetics

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Plant-based treatments are crucial in achieving Sustainable Development Goal 3 (SDG 3) to ensure healthy lives and promote well-being. Integrating effective and safe herbal medical systems with traditional pharmaceutical systems can significantly enhance essential healthcare services. A survey conducted in Germany revealed that various age groups opt for herbal remedies due to dissatisfaction with allopathic treatments, the synergistic effects of medicinal plants, historical usage, and unique knowledge [1]. In the face of emerging diseases like SARS-COV-2 and mycosis, interest in phytotherapy has been rekindled to strengthen the healthcare system and combat the ongoing epidemic. Immunity-boosting plants, herbal remedies, and AYUSH compositions are being considered as preventive measures. Specific botanical formulations include the aqueous solution of Guduchi and pippali, AYUSH 64, and Guduchi aq. extracts have shown promise for mild to moderate and asymptomatic COVID-19 patients [2]. Ashwagandha and Guduchi extracts are also recommended for preventive use against COVID-19, with Withaferin A potentially acting as a therapeutic agent to inhibit viral spread. However, further research is needed to determine the long-term safety and optimal dosage [3]. Currently, herbal medicines straddle the line between conventional drugs and food. This chapter elucidates their historical significance, integration into modern healthcare, and metabolic and pharmacokinetic profiles within the human body. Importance of understanding herbal formulations' metabolism and pharmacokineticsResearchers are increasingly curious about the impact of herbal formulations on metabolism and pharmacokinetics. Pharmacokinetics (PK), a newly developed approach, is instrumental in studying drug absorption, distribution, metabolism, and excretion in vivo. When combined with other techniques, PK helps determine the active components of medicinal plants [4][5][6]. Pharmacokinetic measures like biological half-life, clearance, and AUC reveal dynamic processes of these components in vivo. Contrasting pharmacokinetic parameters aids in understanding their characteristics [7,8]. This has three benefits: precise explanation of herbal formulation effects

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Effects of Specific Foods and Dietary Components on Drug Metabolism

Cited by 3 publications

References 147 publications

Drug–Nutrient Interactions: A Broad View with Implications for Practice

Drug–Nutrient Interactions: A Broad View with Implications for Practice

Food–Drug Interactions with Fruit Juices

Introductory Chapter: Pharmacokinetics and Drug Metabolism with Special Reference to Herbal Formulations

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