Effects of specific antisense oligonucleotide inhibition of Fas expression on T cell apoptosis induced by Fas ligand

Mao, Hongzhi; Liu, Qian; Zhang, Jiao; Gu, Hongtao; Wang, Li; Zhou, Xian-Bin; Yin, Hui; Zhang, Ling; Xie, Fengxiang; Jiang, Guosheng

doi:10.1016/j.intimp.2007.09.010

Cited by 1 publication

(1 citation statement)

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“…p53 expression was blocked using antisense ODN resulting in a decrease in the number of cells in G1 phase of the cell cycle and in the promotion of mitosis and PCNA (proliferating cell nuclear antigen) expression, all of which are beneficial in liver restoration. Another group (52) designed ODNs targeted to Fas ligand and transfected it into Jurkat cells and found that the transfected cells underwent apoptosis at a slower rate. More interestingly, certain ODN products (not primarily designed to be antiapoptotic, helped in maintaining and increasing cell viability in-vitro and in-vivo) which are non-specific to apoptotic genes proved to be versatile once introduced into cells.…”

Section: Antisense In Anti-apoptosismentioning

confidence: 99%

Antisense Makes Sense in Engineered Regenerative Medicine

et al. 2008

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The use of antisense strategies such as ribozymes, oligodeoxynucleotides (ODNs) and small interfering RNA (siRNA) in gene therapy, in conjunction with the use of stem cells and tissue engineering, has opened up possibilities in curing degenerative diseases and injuries to non-regenerating organs and tissues. With their unique ability to down-regulate or silence gene expression, antisense oligonucleotides are uniquely suited in turning down the production of pathogenic or undesirable proteins and cytokines. Here, we review the antisense strategies and their applications in regenerative medicine with a focus on their efficacies in promoting cell viability, regulating cell functionalities as well as shaping an optimal microenvironment for therapeutic purposes.

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Section: Antisense In Anti-apoptosismentioning

confidence: 99%