The objective of the present study was to investigate the effects of: 3% sodium lactate (SL), 0.2% potassium sorbate (KS) and 0.5% cetylpyridinium chloride (CPC) on the physicochemical properties ,microbial count and sensory evaluation of ground beef, stored at 4°C for O, 3, 6 and 9 days.All treatments showed significant increase in dry matter content (protein, fat and ash) (P<0.05) and decrease in moisture content with elongation storage time. The SL, KS and CPC significantly increased the pH and water holding capacity (WHC) during all the storage periods. Total volatile nitrogen (TVN), thiobarbituric acid value (TBA), peroxide value (PV) and free fatty acids (FFA) were lower (P<0.05) in SL, KS and CPC treated samples, as compared with the control sample at any refrigerated storage period. The SL, KS and CPC caused significant (P<0.05) decrease in drip loss and cooking loss. Results indicated significant sensory evaluation improvement (P<0.05) in the organoleptic characteristics of ground beef (flavour, juiciness, tenderness, colour and overall palatability). The SL, KS and CPC significantly reduced (P<0.05) the total plate count and psychrophilic count during refrigerated storage periods. It can be concluded that SL, KS and CPC had positive significant influence on quality characteristics, sensing and microbial safety of ground beef when stored under refrigeration at 4C° up to 9 days.