Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats

Perumal, Deepa Kameswari; Adhimoolam, Mangaiarkkarasi; Ivan, Erli Amel; Rajamohammed, Meher Ali

doi:10.5455/njppp.2019.9.0621617062019

Natl J Physiol Pharm Pharmacol

2019

DOI: 10.5455/njppp.2019.9.0621617062019

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Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats

Deepa Kameswari Perumal¹,

Mangaiarkkarasi Adhimoolam²,

Erli Amel Ivan³

et al.

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2024

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Articulating the Pharmacological and Nanotechnological Aspects of Genistein: Current and Future Prospectives

Bansal,

Singh,

Mishra

et al. 2024

CPB

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Throughout the past several centuries, herbal constituents have been the subject of scientific interest and the latest research into their therapeutic potential is underway. Genistein is a soy-derived isoflavone found in huge amounts in soy, along with the plants of the Fabaceae family. Scientific studies have demonstrated the beneficial effects of genistein on various health conditions. Genistein presents a broad range of pharmacological activities, including anticancer, neuroprotective, cardioprotective, antiulcer, anti-diabetic, wound healing, anti-bacterial, antiviral, skin, and radioprotective effects. However, the hydrophobic nature of genistein results in constrained absorption and restricts its therapeutic potential. In this review, the number of nanocarriers for genistein delivery has been explored, such as polymeric nanoparticles, nanostructured lipid carriers, solid lipid nanoparticles, liposomes, micelles, transferosomes, and nanoemulsions and nanofibers. These nano-formulations of genistein have been utilized as a potential strategy for various disorders, employing a variety of ex vivo, in vitro, and in vivo models and various administration routes. This review concluded that genistein is a potential therapeutic agent for treating various diseases, including cancer, neurodegenerative disorders, cardiovascular disorders, obesity, diabetes, ulcers, etc., when formulated in suitable nanocarriers.

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Articulating the Pharmacological and Nanotechnological Aspects of Genistein: Current and Future Prospectives

Bansal,

Singh,

Mishra

et al. 2024

CPB

View full text Add to dashboard Cite

show abstract

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Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats

Cited by 1 publication

References 0 publications

Articulating the Pharmacological and Nanotechnological Aspects of Genistein: Current and Future Prospectives

Articulating the Pharmacological and Nanotechnological Aspects of Genistein: Current and Future Prospectives

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