Effects of somatostatins on gonadotrophic cells in female rats

Lovren, Mirjana; Sekulić, Milka; Milošević, Verica; Radulović, Nataša

doi:10.1016/s0065-1281(98)80020-2

Cited by 12 publications

(17 citation statements)

References 18 publications

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“…Our histological analysis of FSH and LH cells in middle-aged female rats showed that they were both ovoid and polyhedral in shape, occurred individually or more frequently in clusters, and established close contact with blood vessels (Figure 1 a, c) (15). Their nuclei appeared to be round, vesicular and mostly eccentric (Figure 1 a, c) (23).…”

Section: Menopausal Rat Pituitary Hormone-producing Cellsmentioning

confidence: 97%

“…Various animal models have been developed to define the space for problematising the multiple morphofunctional changes during menopause, as well as to solve the present controversies regarding the application of estradiol in humans. Our experimental work in the field implied the usage of intact middle-aged (14 months old) or ovariectomised adult (3 months old) Wistar female rats, for which the pituitary histological and hormone secreting studies had a central role (10,11,(15)(16)(17)(18). Herein, we aim to present the accumulated data regarding the various populations of anterior pituitary hormone-producing cells in our animal models of menopause and in related studies, as well as to elaborate the observed effects of synthetic estradiol application in these experimental studies.…”

Section: Starenje Kod žEnskog Pola Je Biološki Proces Tokom Kojeg Dolmentioning

confidence: 99%

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Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Milošević

Ajdžanović

2014

Serbian Journal of Experimental and Clinical Research

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Female ageing represents the biological process of structural and functional changes in endocrine cells and tissues, as well as in pituitary hormone-producing cells. In addition to the hypothalamic releasing hormones, estradiol plays a signifi cant role in the regulation SAŽETAK Starenje kod ženskog pola je biološki proces tokom kojeg dolazi do promena u strukturi i funkciji endokrinih ćelija i tkiva, a posebnu osetljivost ispoljavaju hipofi zne hormonprodukujuće ć elije. Pored oslobađajućih hormona hipotalamusa i estradiol ostvaruje zapaženu ulogu u regulaciji sinteze i sekrecije hipofi znih hormona, a još uvek se koristi u terapiji menopauzalnih tegoba. Efekti starenja ili ovarijektomije, kao i primene sintetskog estradiola pod tim okolnostima su ispitivani na hormon-produkujućim ć elijama hipofi ze ženki pacova srednjeg doba (animalni modeli menopauze) i to: gonadotropima (FSH i LH), tirotropima (TSH), somatotropima (GH), mamotropima (PRL) i kortikotropima (ACTH

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Section: Menopausal Rat Pituitary Hormone-producing Cellsmentioning

confidence: 97%

Section: Starenje Kod žEnskog Pola Je Biološki Proces Tokom Kojeg Dolmentioning

confidence: 99%

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Milošević

Ajdžanović

2014

Serbian Journal of Experimental and Clinical Research

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“…However, the mechanism behind this action remains speculative. Moreover, indirect effects of SOM cannot be excluded, as SOM was demonstrated to directly affect gonadotropic cell number and morphology (Lovren et al 1998). Here we propose three possible pathways via which SOM, originating from the PeVN, may affect GnRH neurons, resulting in a decreased LH release (see Figure 4).…”

Section: Effect Of Som On the Reproductive Axismentioning

confidence: 99%

“…SOM was shown to directly decrease LH release (Yu et al, 1997) and affect gonadotroph cell number and morphology (Lovren et al, 1998). Moreover, both gonadotrophs and somatotrophs express SSTRs.…”

Section: Pathway 3: Som Effects Pituitary Lh Release Indirectlymentioning

confidence: 99%

“…(Estupina et al, 1996, Zorrila et al, , 1991. Central injections with SOM or a SOM analog (octreotide) decreased the number of gonadotropic cells in the pituitary (Lovren et al, 1998;Nestorovic et al 2002;. Also, we previously showed that a single central injection with octreotide significantly attenuated the E 2 -induced Luteinizing Hormone (LH) surge and significantly decreased the activation of Gonadotropin Releasing Hormone (GnRH) cells in the hypothalamus of female rats (van Vugt et al, 2004).…”

Section: Introductionmentioning

confidence: 97%

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Somatostatin in the Periventricular Nucleus of the Female Rat: Age Specific Effects of Estrogen and Onset of Reproductive Aging

Beek¹,

Vugt²,

Franke³

et al. 2012

Sex Steroids

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Somatostatin-14 influences pituitary–ovarian axis in peripubertal rats

Nestorović

Manojlović‐Stojanoski

Ristić

et al. 2008

Histochem Cell Biol

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The effects of multiple somatostatin (SRIH-14) administration on the pituitary-ovarian axis were examined in peripubertal rats. Female Wistar rats received subcutaneously, two daily doses of 20 microg SRIH-14 per 100 g body weight (b.w.) for five consecutive days (from the 33rd to the 37th day of life). Follicle-stimulating (FSH), luteinizing (LH) and somatotropic (GH) cells were examined by the peroxidase-anti-peroxidase immunocytochemical method. Changes in cell volumes, volume densities and number per unit area (mm(2)) of FSH-, LH- and GH-immunoreactive cells were evaluated by stereology and morphometry. Serum FSH and LH levels were determined by RIA. Ovaries were analyzed by simple point counting of follicles. The volumes and volume densities of FSH-, LH- and GH-immunoreactive cells were significantly decreased while their numbers per mm(2) remained unchanged. SRIH-14 induced a significant decrease in serum FSH and LH levels. In the ovary, SRIH-14 induced an increase in the number of primordial follicles, followed by a reduction in the number of small healthy growing follicles and absence of preovulatory follicles. The number of atretic follicles was unchanged. We concluded that treatment with SRIH-14 during the peripubertal period markedly inhibited pituitary FSH, LH and GH cells. In the ovary, SRIH-14 acted by inhibiting folliculogenesis without affecting atretic processes.

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Effects of somatostatins on gonadotrophic cells in female rats

Cited by 12 publications

References 18 publications

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Somatostatin in the Periventricular Nucleus of the Female Rat: Age Specific Effects of Estrogen and Onset of Reproductive Aging

Somatostatin-14 influences pituitary–ovarian axis in peripubertal rats

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