Effects of soluble fiber on matrix metalloproteinase-2 activity and healing of colon anastomosis in rats given radiotherapy

Kerem, Mustafa; Bedirli, Abdülkadir; Karahacioglu, Eray; Paşaoğlu, Hatîce; Şahin, Önder; Bayraktar, Nilüfer; Yılmaz, Tonguç Utku; Şakrak, Ömer; Göksel, Fatih; Oğuz, Mehmet

doi:10.1016/j.clnu.2006.01.028

Cited by 25 publications

(30 citation statements)

References 24 publications

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“…Generally, the bursting pressure is considered to reflect the physiological strain in the intestine more accurately than the breaking strength [16]. In addition, the bursting 10 pressure shows indirect collagen formation and reflects the balance between collagen deposition and lysis [30]. Therefore, the ABP might be regarded as not only an integrated measure of anastomotic wound healing but also the absolute outcome of gastrointestinal anastomoses.…”

Section: Discussionmentioning

confidence: 99%

Effects of Platelet-Rich Plasma on Intestinal Anastomotic Healing in Rats: PRP Concentration is a Key Factor

Yamaguchi

Terashima

Yoneyama

et al. 2012

Journal of Surgical Research

115

114

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Section: Discussionmentioning

confidence: 99%

Effects of Platelet-Rich Plasma on Intestinal Anastomotic Healing in Rats: PRP Concentration is a Key Factor

Yamaguchi

Terashima

Yoneyama

et al. 2012

Journal of Surgical Research

115

114

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“…cell proliferation and angiogenesis. Several MMPs such as collagenase (MMP-1), the gelatinases (MMP-2 and MMP-9) and stromelysin (MMP-3) have been shown to be up-regulated in the direct vicinity of the healing anastomosis [6][7][8] . An increased presence of the active forms of these MMPs could lead to localized matrix degradation and transient loss of anastomotic strength [9,10] .…”

mentioning

confidence: 99%

Effects of Two Conventional Preoperative Radiation Schedules on Anastomotic Healing in the Rat Colon

Bedirli¹,

Kerem²,

Karahacioglu

et al. 2007

Eur Surg Res

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Background: Preoperative radiotherapy (RT) is an increasingly popular form of adjunct therapy for rectal cancer; however, little is known about its effects on matrix metalloproteinase (MMP) expression in colonic anastomotic healing. Methods: Wistar rats were irradiated to a total dose of 25 or 40 Gy. Four days after the end of RT, an end-to-end colorectal anastomosis was performed. Animals were sacrificed at 1, 3, and 7 days after the anastomosis. A control group was studied similarly, but was not irradiated. Results: No significant differences were found in peritonitis rate and anastomotic complications. The average bursting pressure and breaking strength were only reduced significantly in the rats irradiated with 40 Gy. However, the concentration and the content of hydroxyproline in anastomotic tissues were unchanged. In irradiated rats, MMP-2 and MMP-9 were significantly increased at 40 Gy, but not at 25 Gy. On the other hand, 25-Gy irradiation induced a smaller increase in the levels of the tissue inhibitors of metalloproteinase-1 compared with the controls. Conclusion: Anastomotic strength is adversely affected by high-dose fractionated preoperative RT. In contrast, preoperative RT at 25 Gy in five fractions over 5 days is safe with regard to the maintenance of wound strength in colorectal anastomosis.

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“…Generally, the bursting pressure is considered to reflect the physiologic strain in the intestine more accurately than the breaking strength [23]. In addition, the bursting pressure shows indirect collagen formation [24] and reflects the balance between collagen deposition and lysis. Therefore, the ABP might be regarded as not only an integrated measure of anastomotic wound healing but also the absolute outcome of gastrointestinal anastomoses.…”

Section: Discussionmentioning

confidence: 99%

Early Postoperative Oral Intake Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

Tadano

Terashima

Fukuzawa

et al. 2011

Journal of Surgical Research

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Effects of soluble fiber on matrix metalloproteinase-2 activity and healing of colon anastomosis in rats given radiotherapy

Cited by 25 publications

References 24 publications

Effects of Platelet-Rich Plasma on Intestinal Anastomotic Healing in Rats: PRP Concentration is a Key Factor

Effects of Platelet-Rich Plasma on Intestinal Anastomotic Healing in Rats: PRP Concentration is a Key Factor

Effects of Two Conventional Preoperative Radiation Schedules on Anastomotic Healing in the Rat Colon

Early Postoperative Oral Intake Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model

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