Effects of solar radiations on stratum corneum hydration: Part I, protective role of skin surface lipids

Assi, Ali; Michael‐Jubeli, Rime; Duplan, Hélène; Baillet‐Guffroy, Arlette; Jacques, Carine; Tfayli, Ali

doi:10.1002/jbio.202300055

Journal of Biophotonics

2023

DOI: 10.1002/jbio.202300055

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Effects of solar radiations on stratum corneum hydration: Part I, protective role of skin surface lipids

Ali Assi

Rime Michael‐Jubeli

Hélène Duplan

et al.

Abstract: This study used Raman spectroscopy to develop a new approach to evaluate the effects of solar radiation on the stratum corneum (SC). The method measures the SC's hydration and dehydration kinetics by calculating the vOH/vCH ratio to mon-

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Cited by 4 publications

References 55 publications

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Quantification of skin penetration of caffeine and propylene glycol applied topically in a mixture by tailored multivariate curve resolution‐alternating least squares of depth‐resolved Raman spectra

Choe,

Pak,

Ascencio

et al. 2023

Journal of Biophotonics

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The quantitative determination of topically applied substances in the skin is severely limited and represents a challenging task. The porcine skin ex vivo was topically treated with a gel containing caffeine (CF) and propylene glycol (PG), and depth‐resolved Raman spectra were recorded with two confocal Raman microscopes. We applied a novel tailored multivariate curve resolution‐alternating least squares (tMCR‐ALS) method to the selected spectral regions (512–604 and 778–1148 cm‐1) of gel‐treated skin and quantitatively determined the concentrations of CF and PG in the stratum corneum (SC). The highest concentration of CF (181 mg/cm3) was found at the surface, while PG (384 mg/cm3) was found at 10% SC depth, indicating the formation of a reservoir at the superficial SC. The concentrations of CF and PG decreased monotonically and reached the detection limit at ≈60% and ≈80% SC depth, respectively, indicating that neither permeate the SC.This article is protected by copyright. All rights reserved.

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Quantification of skin penetration of caffeine and propylene glycol applied topically in a mixture by tailored multivariate curve resolution‐alternating least squares of depth‐resolved Raman spectra

Choe,

Pak,

Ascencio

et al. 2023

Journal of Biophotonics

View full text Add to dashboard Cite

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Effects of solar radiations on stratum corneum hydration: Part II, protective action of solar filters

Assi,

Michael‐Jubeli,

Duplan

et al. 2024

Journal of Biophotonics

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The skin surface lipids (SSLs) film, composed of sebum and keratinocyte membrane lipids, is crucial to the barrier function of the stratum corneum (SC). The first part of this study investigated the impact of solar radiation on the SC based on a novel hydration and dehydration approach using Raman spectroscopy. The SSLs were found to absorb solar light, and thus participate to the protection of the skin surface. However, the protective function of the SSLs may be limited and is dependent to the heterogenous distribution of SSLs over the body surface. To ensure comprehensive protection, synergistic measures such as the application of solar filters are necessary. In this second part of the study, we have evaluated the limits of the protection capacity of SSLs and explored the protective action of a solar filters on both SSLs composition and the water hydration and dehydration kinetics in the SC.

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A novel method for calculating solar radiation on indoor human body under different weather conditions

Xiang,

He,

et al. 2024

Building and Environment

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Effects of solar radiations on stratum corneum hydration: Part I, protective role of skin surface lipids

Abstract: This study used Raman spectroscopy to develop a new approach to evaluate the effects of solar radiation on the stratum corneum (SC). The method measures the SC's hydration and dehydration kinetics by calculating the vOH/vCH ratio to mon-

Cited by 4 publications

References 55 publications

Quantification of skin penetration of caffeine and propylene glycol applied topically in a mixture by tailored multivariate curve resolution‐alternating least squares of depth‐resolved Raman spectra

Quantification of skin penetration of caffeine and propylene glycol applied topically in a mixture by tailored multivariate curve resolution‐alternating least squares of depth‐resolved Raman spectra

Effects of solar radiations on stratum corneum hydration: Part II, protective action of solar filters

A novel method for calculating solar radiation on indoor human body under different weather conditions

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