Effects of sodium hydrogen sulfide (a H2S donor) on acute kidney injury

Mansouri, Esrafil

doi:10.15171/jnp.2018.01

Cited by 3 publications

(1 citation statement)

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“…The findings have revealed that H2S affected renal function and ameliorated multiple kidney disorders including nephrotoxicity, renal ischemia/reperfusion injury, and obstructive nephropathy (7). In addition, prescription of H2S alleviates STZ-induced diabetic retinopathy through suppressing inflammation and eliminating oxidative stress (8).…”

Section: Introductionmentioning

confidence: 99%

Effect of sodium hydrogen sulfide (NaHS) on contrast-induced acute kidney injury; an experimental histopathological study

Nasri,

Noorshargh,

Hooshyar

et al. 2019

J Nephropathol

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Introduction: Contrast-induced nephropathy (CIN) is associated with a minimum increase of 25% of the creatinine base or an increase in creatinine of 0.5 mg/dL during 2-3 days after the administration of the contrast agent Objectives: The present investigation was designed to examine the effect of sodium hydrogen sulfide (NaHS) on contrast-induced acute kidney injury in rats. Materials and Methods: Forty male Wistar rats randomly assigned into four groups, 10 rats for each group. Group 1; normal rats (control group; sham group); they did not receive any drugs. Group 2; rats were received 10 mL/kg as a single dose of iodixanol (contrast media) by intravenous (IV) injection. Group 3; they received 10 mg/kg of NaHS by intraperitoneal (IP) injection for three days, while in day forth, rats received a single dose of iodixanol (10 mL/kg). Group 4; rats of this group, first received a single dose of iodixanol (10 mL/kg). Then rats were treated by NaHS (10 mg/kg) by intraperitoneal (IP) injection for 3 days (days 2, 3 and 4).The kidneys were removed immediately after sacrificing and prepared for morphological examination. Kidney sections were examined for intensity of kidney damage by examination for degeneration, flattening, and necrosis of renal tubular cells and also dilatation of tubular lumen. Results: We detected a significant difference between groups regarding the morphologic variables of damage (P=0.001; one-way ANOVA). A significant difference of morphologic variables of damage (degeneration, flattening, necrosis, and dilatation) among the groups was seen too (P=0.001; one-way ANOVA). The study showed a significant difference between groups II (contrast media) with III (rats pretreated by NaHS) (P<0.001). Moreover, we detected a significant difference between groups II (contrast media) and IV (rats post-pone treated by NaHS) (P<0.001). However, there was not a significant difference between the groups of III and IV (P>0.05). Conclusion: Post-pone treatment of NaHS was as effective as the pretreatment to mitigate the renal damage induced by contrast media.

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Section: Introductionmentioning

confidence: 99%

Effect of sodium hydrogen sulfide (NaHS) on contrast-induced acute kidney injury; an experimental histopathological study

Nasri,

Noorshargh,

Hooshyar

et al. 2019

J Nephropathol

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Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

Azarbarz

Seifabadi

Moaiedi

et al. 2020

Environ Sci Pollut Res

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A Comprehensive Overview of Hibiscus rosa-sinensis L.: Its Ethnobotanical Uses, Phytochemistry, Therapeutic Uses, Pharmacological Activities, and Toxicology

Amtaghri,

Qabouche,

Slaoui

et al. 2024

EMIDDT

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Hibiscus rosa-sinensis (H. rosa-sinensis) has been largely used in traditional medicine. This study aims to review the pharmacological and phytochemical properties of Hibiscus rosa-sinensis L and also summarize the pharmacological, photochemical, and toxicological characteristics of H. rosa-sinensis. The current review focuses on the distribution, chemical content, and main uses of H. rosa-sinensis. Various scientific databases, including ScienceDirect, Scopus, PubMed, Google Scholar, etc., were used. Correct plant names were verified from plantlist.org. The results were interpreted, analyzed, and documented based on bibliographic information. This plant has been frequently used in conventional medicine due to its high concentration of phytochemicals. All its parts contain numerous chemical compounds, such as flavonoids, tannins, terpenoids, anthocyanins, saponins, cyclopeptide alkaloids, and vitamins. More interestingly, the roots of this plant contain glycosides, tannins, phytosterols, fixed oils, fats, flavonoids, saponins, gums, and mucilages. The leaves contain alkaloids, glycosides, reducing sugars, fat, resin, and sterols. The stem contains other chemical compounds, such as ß-sitosterol, teraxeryl acetate, cyclic sterculic, and malvalic acids. Finally, the flowers contain riboflavin, thiamine, apigenidine, oxalic acid, citric acid, quercetin, niacin, pelargonidine, and ascorbic acid. This species has a wide variety of pharmacological applications, such as antimicrobial, antioxidant, antidiabetic, anti-inflammatory, antihypertensive, antifertility, antifungal, anticancer, hair growth-promoting, antihyperlipidemic, reproductive, neurobehavioral, antidepressant, and antipyretic activities. Finally, toxicological studies have shown that higher doses of extracts from the plant are safe.

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Effects of sodium hydrogen sulfide (a H2S donor) on acute kidney injury

Cited by 3 publications

References 4 publications

Effect of sodium hydrogen sulfide (NaHS) on contrast-induced acute kidney injury; an experimental histopathological study

Effect of sodium hydrogen sulfide (NaHS) on contrast-induced acute kidney injury; an experimental histopathological study

Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

A Comprehensive Overview of Hibiscus rosa-sinensis L.: Its Ethnobotanical Uses, Phytochemistry, Therapeutic Uses, Pharmacological Activities, and Toxicology

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