Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers

Zou, Xiaoting; Ji, Junfu; Qu, Hao; Wang, J; Shu, Dingming; Wang, Y; Liu, T.F.; Li, Y; Luo, Chenglong

doi:10.3382/ps/pez279

Cited by 94 publications

(88 citation statements)

References 35 publications

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“…Gastrointestinal tract integrity is crucial to nutrition absorption, immunity development, and disease resistance, together with the gut microbial community balance. Alterations in the gut microbial community may adversely affect feed efficiency, productivity, and health of chickens (Kohl 2012;Wu et al 2018;Kogut 2019;Zou et al 2019). The gut microbiota in broiler chickens is characterised by a prevalence of Firmicutes and Bacteroidates, as confirmed in the present study, whereas Enterobacteriaceae are usually associated with gut dysbiosis, which, in turn, causes low microbial diversity (Kogut 2019).…”

Section: Discussionsupporting

confidence: 72%

“…Additionally, dietary supplementation with Nabutyrate (1000 mg/kg) has been found to reduce compositional changes in caecal microflora when chickens were fed a low-energy low-amino acid diet compared with a control diet (Bortoluzzi et al 2017). Finally, dietary supplementation with encapsulated Na-butyrate (150 or 300 mg/kg; 99.9% butyrate salt) did not modify the composition and structure of the microbial community in chickens submitted to gut inflammation when compared with healthy chickens (Zou et al 2019). Thus, based on previous discussion, dietary butyrate could be more effective in modifying gut composition in chickens challenged by nutritional or health issues compared with healthy chickens, but both the dose and the form of supplementation may play a specific role.…”

Section: Discussionmentioning

confidence: 96%

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Dietary supplementation with sodium butyrate: growth, gut response at different ages, and meat quality of female and male broiler chickens

Pascual

Trocino

Birolo

et al. 2020

Italian Journal of Animal Science

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The present study aimed to evaluate how dietary supplementation with a microencapsulated sodium butyrate (500 mg/kg; 30% Na-butyrate) in 768 male and female broiler chickens affected growth performance, jejunum gut morphology and caecal microbiome at different ages (11, 24, and 35 d), slaughter results, meat quality, and myopathy (white striping, wooden breast, and spaghetti meat) occurrence. No health problem was recorded (mortality < 1%) and Na-butyrate supplementation did not affect performance throughout the trial, nor did it affect gut morphology or microbiota composition and abundance at different ages. Additionally, dietary treatment did not affect slaughter results, meat quality, or myopathy rate, whereas the rate of females affected by spaghetti meat tended to be higher in those fed the control compared with the Na-butyrate diet (33.3% versus 16.7%; p ¼ .06). Moreover, males showed a higher wooden breast (21.9% versus 7.3%; p .01) and a lower spaghetti meat (3.1% versus 25.0%; p .001) rate compared with females. Finally, the richness index (i.e. the number of different species represented in an ecological community, landscape, or region) in the caecum increased (p .001) with increasing chicken age, and the community composition was also affected (adonis p .001). In conclusions, under the good health condition of the present trial, the tested Nabutyrate had no effect on performance and gut response at different ages of broiler chickens. Moreover, the occurrence of spaghetti meat and wooden breast differed between males and females. HIGHLIGHTS Under optimal health conditions, Na-butyrate supplementation did not affect performance or gut response at different ages of broiler chickens. Males showed a significantly higher occurrence of wooden breasts, whereas females had higher rates of spaghetti meat. In females, the Na-butyrate supplementation tended to reduce the occurrence of spaghetti meat.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 96%

Dietary supplementation with sodium butyrate: growth, gut response at different ages, and meat quality of female and male broiler chickens

Pascual

Trocino

Birolo

et al. 2020

Italian Journal of Animal Science

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“…The LPS injection volume was 0.5 mg/kg bodyweight (diluted with sterilized saline to 0.5 mg/mL) at 500 µg/mL/kg dissolved in sterile saline. Con group animals received an equivalent amount of sterile saline [19]. At 21 d of age, 6 broiler chickens randomly selected from each group were slaughtered and samples were collected.…”

Section: Animals Treatmentmentioning

confidence: 99%

Quercetin Protects against Lipopolysaccharide-Induced Intestinal Oxidative Stress in Broiler Chickens through Activation of Nrf2 Pathway

Sun

Dong

et al. 2020

Molecules

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We investigated the potential ability of quercetin to protect against lipopolysaccharide (LPS)-induced intestinal oxidative stress in broiler chickens and the potential role of the Nrf2 (nuclear factor erythroid 2-related factor 2) signaling pathway. One-day-old broiler chickens (n = 240) were randomized into four groups: saline-challenged broiler chickens fed a basal diet (Con), LPS-challenged broiler chickens on a basal diet (LPS), and LPS-treated broiler chickens on a basal diet containing either 200 or 500 mg/kg of quercetin (Que200+LPS or Que500+LPS). Quercetin (200 mg/kg) significantly alleviated LPS-induced decreased duodenal, jejunal, and illeal villus height and increased the crypt depth in these regions. Quercetin significantly inhibited LPS-induced jejunal oxidative stress, including downregulated reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, and it upregulated superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels. Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1). Quercetin attenuated the LPS-induced inhibition of Nrf2 activation, translocation, and downstream gene expression, including heme oxygenase-1 (HO-1), NAD (P) H dehydrogenase quinone 1 (NQO1), and manganese superoxide dismutase (SOD2). Additionally, quercetin attenuated the LPS-inhibition of c-Jun N-terminal kinase (JNK), Extracellular Regulated protein Kinases (ERK), and p38MAPK (p38) phosphorylation in the MAPK pathway. Thus, quercetin attenuated LPS-induced oxidative stress in the intestines of broiler chickens via the MAPK/Nrf2 signaling pathway.

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“…Although not completely understood, the growth-promoting mechanism of these products is thought to be related to the specific changes induced in the intestinal microbiota composition and function ( Ducatelle et al., 2015 ). For instance, the cecal diversity was shown to be significantly impacted by the use of sodium butyrates, which could be associated with a decreased relative abundance of Lactobacillaceae ( Zou et al., 2019 ). In a study by Bortoluzzi et al.…”

Section: Discussionmentioning

confidence: 99%

Impacts of antibiotic reduction strategies on zootechnical performances, health control, and Eimeria spp. excretion compared with conventional antibiotic programs in commercial broiler chicken flocks

et al. 2020

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Increasing efforts have been made in recent years to reduce antimicrobial use in animal production. The objective of this prospective study was to evaluate, in commercial broiler chicken farms, 2 antibiotic reduction strategies that eliminated the use of antibiotics important for human medicine, in comparison with the conventional use of antibiotics. On 7 broiler chicken farms, a house was allocated to the antibiotic reduction treatments for 6 consecutive flocks, whereas a similar house on the same premises was assigned to the conventional use of antibiotics ( CONV ) for 6 consecutive flocks. The antibiotic reduction strategies consisted of continuous in-feed use of ionophores ( TX1 ) and continuous in-feed use of ionophores with butyric acid ( TX2 ). In the 84 flocks, zootechnical performance was recorded, lesion scoring at 21 and 28 D of age was performed, and fecal samples were recovered during grow out for Eimeria spp. oocysts counts. There was no statistical difference between TX1, TX2, and CONV for weights at slaughter, feed conversion ratios, average daily gains, age at slaughter, total mortalities, and condemnations. The probability of identifying oocysts in the fecal samples significantly increased with the age of the flock, but there was no significant treatment effect between 7 and 16 D of age. At 19 D of age, the probability of a sample containing oocysts was higher in TX1 than in CONV, but TX2 was not statistically different from TX1 and CONV. Predicted oocysts per gram in CONV flocks were significantly lower between 22 and 34 D of age than in TX1 and TX2 flocks, whereas there were no significant differences between TX1 and TX2 for all ages. Lesion scoring of the gastrointestinal system showed no differences for coccidiosis scores between TX1, TX2, and CONV. No lesions of necrotic enteritis were observed. In conclusion, it was possible to adequately control intestinal diseases and maintain zootechnical performances by relying exclusively on ionophores, when compared with broiler chicken flocks using standard shuttle programs with antibiotic growth promoters.

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Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers

Cited by 94 publications

References 35 publications

Dietary supplementation with sodium butyrate: growth, gut response at different ages, and meat quality of female and male broiler chickens

Dietary supplementation with sodium butyrate: growth, gut response at different ages, and meat quality of female and male broiler chickens

Quercetin Protects against Lipopolysaccharide-Induced Intestinal Oxidative Stress in Broiler Chickens through Activation of Nrf2 Pathway

Impacts of antibiotic reduction strategies on zootechnical performances, health control, and Eimeria spp. excretion compared with conventional antibiotic programs in commercial broiler chicken flocks

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