Effects of sodium bicarbonate correction of metabolic acidosis on regional tissue oxygenation in very low birth weight neonates

Mintzer, Jonathan; Parvez, Boriana; Alpan, Gad; LaGamma, Edmund F.

doi:10.1038/jp.2015.37

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…Data were acquired during a NIRS survey of VLBW neonates to evaluate region-specific baseline values and changes occurring with routine clinical practices over the first 10 postnatal days. Previous work related to this patient cohort and data set have evaluated booster pRBC transfusions, 10 quiescent baseline variability, 16 sodium bicarbonate corrections, 17 and effects of umbilical arterial blood drawing. 18 This hypothesis-generating pilot analysis was conducted post hoc to evaluate the relationship between hematocrit level and region-specific FTOE.…”

Section: Methodsmentioning

confidence: 99%

Regional Tissue Oxygen Extraction and Severity of Anemia in Very Low Birth Weight Neonates: A Pilot NIRS Analysis

2018

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Section: Methodsmentioning

confidence: 99%

Regional Tissue Oxygen Extraction and Severity of Anemia in Very Low Birth Weight Neonates: A Pilot NIRS Analysis

2018

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“…Therefore, the interest in lactate in relation to the cerebral oxygenation in the neonatal period increased in the last years. Eighteen studies were identified, which investigated cerebral oxygenation and blood lactate level in neonates (7,11,13,15,16,18,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). However, only one of these publications demonstrated a negative association between cerebral oxygenation and lactate (7), and three studies found no association (11,23,29) between these factors.…”

Section: Lactate Level and Cerebral Oxygenationmentioning

confidence: 99%

Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature

et al. 2020

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Background: Cerebral oxygenation monitored non-invasively by near-infrared spectroscopy (NIRS) is of increasing interest in neonatal care. Cerebral oxygenation is determined by cerebral oxygen delivery and cerebral oxygen consumption. Oxygen delivery as well as oxygen consumption might be influenced by metabolic parameters like blood glucose and lactate. Objective: The aim of the present systematic qualitative review is therefore to identify and summarize all studies, which describe cerebral oxygenation measured with NIRS and blood glucose and/or blood lactate levels in neonates. Data sources: A systematic search of Ovid Embase and PubMed was performed. Search terms included near-infrared spectroscopy, fractional tissue oxygen extraction, cerebral tissue oxygen saturation, regional cerebral tissue oxygen saturation, oxygenation, term, and preterm neonates, cesarean delivery, transition, after-birth, newborn, vaginal delivery, cesarean delivery, baby, neonatal transition, metabolism, lactate, glucose, and blood glucose level. Study selection/data synthesis: Studies analyzing cerebral oxygenation and blood glucose and/or blood lactate levels in neonates were included. Animal studies, duplicates, or studies in non-English language were excluded. Results: Twenty-five studies were identified that describe blood glucose and/or blood lactate levels as primary or secondary outcome parameters with additional measured cerebral oxygenation by NIRS in neonates. Twelve studies were included with blood glucose measurements: four described an association between blood glucose levels and cerebral oxygenation, two show no association, and six do not report on possible associations. Eighteen studies were included with lactate measurements: one describe an association between lactate levels and cerebral oxygenation, while three show no association and 14 do not report on possible associations.

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“…These findings suggest that unlike the overall population of patients with metabolic acidosis, those suffering from concomitant acute kidney injury may experience improved outcomes and a reduced rate of mortality from enrolment to day 28 with sodium bicarbonate infusion therapy [19]. Similarly, Zhang et al studied 1718 septic patients (1218 controls and 500 patients who received sodium bicarbonate) and reported no significant mortality change in the overall population (hazard ratio [HR], 1.04; 95% CI, 0.86 to 1.26; p = 0.67], but bicarbonate proved to be beneficial in patients with acute kidney injury (HR, 0.74; 95% CI, 0.51 to 0.86; p = 0.021) [20].…”

Section: Bicarbonate Therapy For Patients With Metabolic Acidosismentioning

confidence: 99%

Bicarbonate Therapy for Critically Ill Patients with Metabolic Acidosis: A Systematic Review

Ghauri

Javaeed²,

Mustafa

et al. 2019

Cureus

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The management of acid-base disorders always calls for precise diagnosis and treatment of the underlying disease. Sometimes additional means are necessary to combat systemic acidity itself. In this systematic review, we discuss the concept and some specific aspects of bicarbonate therapy for critically ill patients with metabolic acidosis (i.e., patients with blood pH < 7.35). We conducted a systematic literature review of three online databases (PubMed, Google Scholar, and Cochrane) in November 2018 to validate usage of bicarbonate therapy for critically ill patients with metabolic acidosis. Twelve trials and case series were included in the final analysis, from which we assessed population, intervention, comparison, and outcome data. The current literature suggests limited benefit from bicarbonate therapy for patients with severe metabolic acidosis (pH < 7.1 and bicarbonate < 6 mEq/L). However, bicarbonate therapy does yield improvement in survival for patients with accompanying acute kidney injury.

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Effects of sodium bicarbonate correction of metabolic acidosis on regional tissue oxygenation in very low birth weight neonates

Cited by 17 publications

References 40 publications

Regional Tissue Oxygen Extraction and Severity of Anemia in Very Low Birth Weight Neonates: A Pilot NIRS Analysis

Regional Tissue Oxygen Extraction and Severity of Anemia in Very Low Birth Weight Neonates: A Pilot NIRS Analysis

Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature

Bicarbonate Therapy for Critically Ill Patients with Metabolic Acidosis: A Systematic Review

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