Effects of sodium arsenite exposure on development and behavior in the rat

Rodrı́guez, V.M.; Carrizales, Leticia; Mendoza, Mónica; Fajardo, O.R; Giordano, Magda

doi:10.1016/s0892-0362(02)00313-6

Cited by 182 publications

(100 citation statements)

References 46 publications

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“…Although the toxicity of arsenic on the protein content of the brain manifested late, its concentration fell to about 55% of the control value after 60 days. This might perhaps be due to the capacity of arsenic to cross the blood brain barrier and accumulate in the brain causing degenerative changes (Rodriguez et al, 2002). Thirumavalavan & Samipillai (2010) also noticed decreased amount of proteins in the brain of Catla catla exposed to 0.1 ppm of arsenic trioxide.…”

Section: Discussionmentioning

confidence: 99%

Study of sodium arsenite induced biochemical changes on certain biomolecules of the freshwater catfish Clarias batrachus

Kumar

Banerjee

2012

Neotrop. ichthyol.

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Toxic impact of sublethal concentration (1 mg/L; 5% of 96h LC 50 value) of sodium arsenite (NaAsO 2 ) on certain biomolecules (proteins, nucleic acids, lipids, and glycogen) of five tissue components (muscles, liver, brain, skin, and gills) of the freshwater catfish Clarias batrachus was analysed. The important toxic manifestations include marked decrease in the concentration of proteins (21.72-45.42% in muscles; 3.42-53.94% in liver; 15.39-45.42% in brain; 15.40-4.00% in skin and 11.35-64.13% in gills), .01% in gills), .93% in skin and 21.47-44.38% in gills) and glycogen (24.00-51.72% in muscles; 49.11-72.45% in liver; 11.49-26.03% in brain; 26.13-38.05% in skin and 17.80-37.97% in gills). Excepting liver where the lipid content increases (15.82-24.13%), the fat content also showed depletion in their concentration (10.40-29.83% in muscles; 8.30-34.45% in brain; 8.94-31.47% in skin and 12.75-28.86% in gills), in the rest of the organ systems.Foi analisado o impacto tóxico da concentração subletal (1 mg/L; 5% do valor de LC50 de 96h) do arsenito de sódio (NaAsO2) sobre certas biomoléculas (proteinas, ácidos nucleicos, lipídios e glicogênio) de cinco tecidos (músculos, fígado, cérebro, pele e brânquias) do bagre Clarias batrachus. As manifestações tóxicas importantes incluiram o decréscimo acentuado na concentração de proteinas (21,72-45,42% nos músculos; 3,42-53,94% no fígado; 15,39-45,42% no cérebro; 15,40-4,00% na pele e 11,35-64,13% nas brânquias), DNA (0,55-22,95% nos músculos; 8,33-14,06% no fígado; 5,30-18,40% no cérebro; 13,57-52,80% na pele e 12,38-31,01% nas brânquias), RNA (42,[68][69][70][71][72][73][74][75][76]16% nos músculos; 10,75% no fígado; 5,05% no cérebro; 7,93% na pele e 21,47-44,38% nas brânquias) e glicogênio (24,00-51,72% nos músculos; 49,11-72,45% no fígado; 11,49-26,03% no cérebro; 26,13-38,05% na pele e 17,80-37,97% nas brânquias). Excetuando o fígado onde o conteúdo de lipídeos aumentou (15,82-24,13%), houve uma depleção na concentração de lipídeos no restante dos sistemas orgânicos (10,40-29,83% nos músculos; 8,30-34,45% no cérebro; 8,94-31,47% na pele e 12,75-28,86% nas brânquias).Key words: Glycogen, Lipids, Nucleic acids, Proteins, Toxicity.Banaras Hindu University, Eco-physiology Unit, Department of Zoology, Varanasi-221 005, India. randhir18bhu@gmail.com (RK), tkbzool@yahoo.co.in (TKB) IntroductionThere has been a continuous and alarming influx of arsenic to aquatic environment worldwide from both naturally occurring and anthropogenic sources (Goering et al., 1999). More than one hundred million people are at high risk of elevated arsenic exposure, mainly via drinking water, as well as by the air born metalloid in the areas with coal burning and industrial emissions. Consumption of the arsenic contaminated fishes collected from the polluted waters might also contribute to bioaccumulation of arsenic in human beings. Hence it is of immense importance to know the arsenic induced damages in the different organ systems of fishes used for human consumption. In an effort to achieve t...

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Section: Discussionmentioning

confidence: 99%

Study of sodium arsenite induced biochemical changes on certain biomolecules of the freshwater catfish Clarias batrachus

Kumar

Banerjee

2012

Neotrop. ichthyol.

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“…Epidemiological studies have demonstrated that exposure to As results in impairments of learning and concentration 10) and deterioration in pattern memory and switching attention in humans 11) . Animals exposed to As showed delay in acquisition and extinction of an operant task 12) , alterations in locomotor behavior and deficits in spatial learning paradigms 13,14) . The above results indicated that As exposure can induce impairment of learning and memory.…”

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confidence: 99%

Subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the Bcl‐2/Bax pathway

Wang

Bai

Guan

et al. 2015

Journal of Occupational Health

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were found in the hippocampus of As-exposed mice. The expressions of the Bcl-2 gene and its protein in the hippocampus of As-exposed mice were significantly lower than those in the control group (p<0.05). However, the expressions of the Bax gene and its protein, and the expression ratio of Bax/Bcl-2 in the hippocampus were significantly higher in the groups exposed to As than in the control group (p<0.05). Moreover, the activity of caspase-3 in the hippocampus of mice exposed to As was higher than that in the control (p<0.05). Conclusions:These results indicate that subchronic exposure to As induces apoptosis in the hippocampus of mice by disturbing normal Bax/Bcl-2 regulatory pathways. Meanwhile, it is suggested that the induced apoptosis in the hippocampus may be at least partly responsible for As-induced neurotoxicity. (J Occup Health 2015; 57: 212-221) Key words: Apoptosis, Arsenic trioxide, Bax, Bcl-2, Hippocampus, Neurotoxicity Arsenic (As), a naturally occurring toxic metalloid found in both inorganic and organic forms, is ubiquitous in the environment and contaminates water as a result of geological and industrial pollution 1) . Moreover, some kinds of arsenide, such as arsenic trioxide (As 2 O 3 ), are also widely used for the treatment of malignant tumors 2) . In As-contaminated areas, the As concentration in drinking water or groundwater ranges from 0.25 to 2.1 ppm and even reaches >3.0 ppm in some severely contaminated areas 3−5) . Exposure to As has been associated with increasing incidences of various chronic diseases, including peripheral vascular disease, cardiovascular disease, diabetes mellitus, and various cancers 6) . As is also a potent neurotoxicant, and subchronic or chronic As exposure causes severe nervous system Abstract: Subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the Bcl-2/Bax pathway: Yachen WANG, et al. Department of Occupational and EnvironmentalHealth, Dalian Medical University, P.R. ChinaObjectives: The aim of this study was to identify whether arsenic (As) exposure could induce hippocampal neural apoptosis in vivo. Methods: Sixty-four mice were randomly divided into 4 groups of 16 each. Group 1 orally received drinking water alone as a control. Groups 2−4 were given arsenic trioxide (As 2 O 3 ) orally at the doses of 1 ppm, 2 ppm and 4 ppm, respectively. All the treatments continued for 60 days. Morphological changes in the hippocampus were observed by HE staining. Apoptosis in the hippocampus was examined by TUNEL assay and transmission electron microscopy. The expression levels of Bcl-2 and Bax genes and their proteins in the hippocampus were determined by realtime PCR and Western blotting. The activity of caspase-3 was determined by spectrophotometry. Results: Abnormal histopathological changes and apoptosis

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“…Rodent studies have reported reproducible results showing neurobehavioral and neurophysiological alterations following a developmental arsenic exposure continuing over different periods of time [116][117][118]. In studies conducted under sub-chronic or chronic exposure conditions, rats treated with arsenite from early gestation exhibited behavioral changes with impaired learning/memory ability [117,118].…”

Section: Arsenicmentioning

confidence: 96%

“…In studies conducted under sub-chronic or chronic exposure conditions, rats treated with arsenite from early gestation exhibited behavioral changes with impaired learning/memory ability [117,118]. For instance, rats treated with 36.7 mg/L arsenite from gestation day (GD) 15 through 4 months of age exhibited significant alterations in spontaneous locomotion and poor performance in the delayed alternation test [117].…”

Section: Arsenicmentioning

confidence: 99%

Zebrafish as a Model for Developmental Neurotoxicity Assessment: The Application of the Zebrafish in Defining the Effects of Arsenic, Methylmercury, or Lead on Early Neurodevelopment

Lee

Freeman

2014

Toxics

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Developmental exposure to neurotoxic chemicals presents significant health concerns because of the vulnerability of the developing central nervous system (CNS) and the immature brain barrier. To date, a short list of chemicals including some metals have been identified as known developmental neurotoxicants; however, there are still numerous chemicals that remain to be evaluated for their potential developmental neurotoxicity (DNT). To facilitate evaluation of chemicals for DNT, the zebrafish vertebrate model system has emerged as a promising tool. The zebrafish possesses a number of strengths as a test species in DNT studies including an abundance of embryos developing ex utero presenting ease in chemical dosing and microscopic assessment at all early developmental stages. Additionally, rapid neurodevelopment via conserved molecular pathways supports the likelihood of recapitulating neurotoxic effects observed in other vertebrates. In this review, we describe the biological relevance of zebrafish as a complementary model for assessment of DNT. We then focus on a metalloid and two metals that are known developmental neurotoxicants (arsenic, methylmercury, and lead). We summarize studies in humans and traditional vertebrate models and then detail studies defining the toxicity of these substances using the zebrafish to support application of this model system in DNT studies.

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Effects of sodium arsenite exposure on development and behavior in the rat

Cited by 182 publications

References 46 publications

Study of sodium arsenite induced biochemical changes on certain biomolecules of the freshwater catfish Clarias batrachus

Study of sodium arsenite induced biochemical changes on certain biomolecules of the freshwater catfish Clarias batrachus

Subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the Bcl‐2/Bax pathway

Zebrafish as a Model for Developmental Neurotoxicity Assessment: The Application of the Zebrafish in Defining the Effects of Arsenic, Methylmercury, or Lead on Early Neurodevelopment

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