Effects of SOD/catalase mimetic platinum nanoparticles on radiation-induced apoptosis in human lymphoma U937 cells

Jawaid, Paras; Rehman, Mati Ur; Yoshihisa, Yoko; Li, Peng; Zhao, Qing; Hassan, Mona M.; Miyamoto, Yusei; Shimizu, Tadamichi; Kondo, Takashi

doi:10.1007/s10495-014-0972-5

Cited by 47 publications

(35 citation statements)

References 39 publications

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“…AD is a chronic or chronically relapsing inflammatory skin disease characterized by the presence of eczematous skin lesions with lichenification, pruritic excoriation, dry skin and susceptibility to skin infections . Use of anti‐inflammatory agents has been shown to be beneficial in protecting against AD . AST is well known as an excellent anti‐inflammatory agent that suppresses pro‐inflammatory cytokine and chemokine expression .…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory effect of astaxanthin in phthalic anhydride‐induced atopic dermatitis animal model

Park

Yeo

Han

et al. 2018

Experimental Dermatology

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In this study, we investigated anti-dermatitic effects of astaxanthin (AST) in phthalic anhydride (PA)-induced atopic dermatitis (AD) animal model as well as in vitro model. AD-like lesion was induced by the topical application of 5% PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 1 mg/mL and 2 mg/mL of AST (10 μg or 20 μg/cm ) was spread on the dorsum of ear or back skin three times a week for four weeks. We evaluated dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB) activity. We also measured tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and immunoglobulin E (IgE) concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). AST treatment attenuated the development of PA-induced AD. Histological analysis showed that AST inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. AST treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as release of TNF-α, IL-1β, IL-6 and IgE. In addition, AST (5, 10 and 20 μM) potently inhibited lipopolysaccharide (LPS) (1 μg/mL)-induced nitric oxide (NO) production, expression of iNOS and COX-2 and NF-κB DNA binding activities in RAW 264.7 macrophage cells. Our data demonstrated that AST could be a promising agent for AD by inhibition of NF-κB signalling.

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Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory effect of astaxanthin in phthalic anhydride‐induced atopic dermatitis animal model

Park

Yeo

Han

et al. 2018

Experimental Dermatology

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“…NP-Pt have fewer side effects on general health than do platinum salts such as cisplatin and localise primarily at target/specific cells or tissues [6, 21 – 22]. Moreover, the size <20 nm of NP-Pt determines their bioavailability for cells and tissue and improves the NP-Pt uptake by cancer cells [6–7, 9, 12, 22]. The inhibition of proliferation processes is crucial to patient treatment in the dynamic fields of oncology, especially neurooncology, where the downregulation proliferation of cancer cells is crucial for the success of treatment [23].…”

Section: Discussionmentioning

confidence: 99%

“…Platinum nanoparticles (NP-Pt) showed dose-dependent toxicity against different types of human cancer cells including breast MCF-7, liver HepG-2 [6], colorectal HT29 [8], lymphoma U937 [9] and glioma U87 [6], U251 [10]. Moreover, NP-Pt combined with hadron cancer therapy created DNA strand breaks and activated apoptosis in HT29 cancer cells [8].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the proliferation status of glioblastoma cell and tumour tissue after nanoplatinum treatment

et al. 2017

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Glioblastoma is one of the most frequent primary brain tumours of the central nervous system, with a poor survival time. With inefficient chemotherapy, it is urgent to develop new strategies for tumour therapy. The present approach is based on the inhibition of cell proliferation using platinum nanoparticles (NP-Pt). The aim of the study was to evaluate and compare the antiproliferative properties of NP-Pt and cisplatin against U87 and U118 glioma cell lines and U87 tumour tissue. NP-Pt and cisplatin were incubated with U87 and U118 glioma cells or administered directly into glioma tumour tissue. Cell morphology, the level of DNA synthesis, the migration of cells, protein expression levels of proliferating cell nuclear antigen (PCNA) and the level of DNA oxidation in glioma tumours were investigated. The results showed that NP-Pt treatment of U87 and U118 glioma cells decreased the level of DNA synthesis and the migration of cancer cells but also downregulated the level of PCNA protein expression in tumour tissue. Furthermore, NP-Pt caused oxidative DNA damage in tumour tissue to a higher degree than cisplatin. Consequently, NP-Pt can be considered as an effective inhibitor of glioblastoma tumour cell proliferation. However, the mechanism of action and potential side effects need to be elucidated further.

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“…It releases of therapeutic targets at the connected malignant cells while minimizing off-target side effects. The nanoparticle absorption however could block the apoptotic processes induced by complementary therapies, [40,41].When the delivering nanoparticle which is especially bonded to the membrane of the malignant cell is heated up by outside field, it could make double effect: damage the membrane by heat and/or release the drug which was delivered to the target [42].…”

Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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Despite the large economic and intellectual efforts, cancer is still not easily treatable disease by conventional therapies. This led ultimately to reconsider hyperthermia, like one of interesting treatment methods connected to immunity and tumor metabolism. Hyperthermia has also the ability to play an additional role when used together with the conventional methods of treatment: surgery, radiotherapy, chemotherapy and immunotherapy. Recent trials in Holland and Germany have demonstrated that hyperthermia can prolong life and decrease disease re-appraisal when used in combination with radiotherapy and chemotherapy. Some tumors seem more responsive than others. In this brief summary we will attempt to give a vision of hyperthermia from a physical stand point, but more importantly we will give clinical and biological aspects. The results obtained in these trials on certain types of cancers such as cervix cancer, recurrent breast cancer and head neck cancer, melanoma, sarcomas, liver, glioblastoma and pancreatic cancer support the use of this technique, although some clinical and technical problems persist and have not been completely resolved.

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Effects of SOD/catalase mimetic platinum nanoparticles on radiation-induced apoptosis in human lymphoma U937 cells

Cited by 47 publications

References 39 publications

Anti‐inflammatory effect of astaxanthin in phthalic anhydride‐induced atopic dermatitis animal model

Anti‐inflammatory effect of astaxanthin in phthalic anhydride‐induced atopic dermatitis animal model

Assessment of the proliferation status of glioblastoma cell and tumour tissue after nanoplatinum treatment

A Brief Overview of Hyperthermia in Cancer Treatment

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