Objectives: To observe the effect of an "Internet plus medical"-based health management service model in patients with nonalcoholic fatty liver disease (NAFLD) and to explore an effective model for NAFLD health management to provide a reference for NAFLD treatment and nursing.Methods: The present study was a randomized, controlled, parallel-group comparison trial. A total of 519 patients with NAFLD were randomly assigned to a routine health education group (N=258) or a health management platform group (N=261). The routine health education group received routine health education, and the health management platform group was treated with the "Internet plus medical"-based health management service model to manage NAFLD. The new model provides closed-loop services for the prevention and rehabilitation of NAFLD through the process of grouping, filing, evaluating, planning, intervening, assessing stage and following up. The two groups were observed for 24 weeks. The results of basic indicators, laboratory indicators, body composition analyses, controlled attenuation parameters (CAP) and quality of life assessment questionnaires were used as evaluation indices. All data of the participants were collected and analyzed prior to and following the intervention, and the differences between the two groups were compared.Results: Compared with the routine health education group, the NAFLD health management service model based on “Internet plus medical” treatment effectively reduced the weight (-3.80±3.11vs -0.12±3.42, P =0.047), body mass index (BMI) (-1.73±1.20 vs -0.14±1.68, P =0.031), CAP (-48.42±10.13 vs 4.13±7.45, P =0.044), aspartate transaminase (AST)/alanine aminotransferase (ALT) value (0.18±0.37 vs 0.04±0.11, P = 0.037), body fat content (-2.24±2.58 vs -0.86±2.78, P =0.194) and visceral fat area (-10.87±15.34 vs -0.55±19.13, P =0.047) of NAFLD patients and improved the quality of life of NAFLD patients in terms of physiological role (96.59 ±11.31 vs 90.69 ± 13.49, P=0.027), vitality (86.57±6.07 vs 81.94±5.78, P=0.001) and general health (78.05±6.35vs 73.61±10.12, P=0.044).Conclusions: The results of the present study preliminarily confirm the validity and development prospects of the "Internet plus medical"-based health management service model in NAFLD. This finding suggests that the model is an evidence-based model of health education and management for NAFLD prevention in China.