Effects of smoking on the lung accumulation of [11C]McN5652

Takano, Akihiro; Ito, Hiroshi; Sudo, Yasuhiko; Inoue, Makoto; Ichimiya, Tetsuya; Yasuno, Fumihiko; Suzuki, Kazutoshi; Suhara, Tetsuya

doi:10.1007/s12149-007-0031-1

Cited by 1 publication

(1 citation statement)

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“…A complete physical and neuropsychiatric examination was done to exclude physical illnesses or neuropsychiatric disorders including substance use disorders (illicit drugs, alcohol or nicotine). Care was taken to ensure that subjects were not smokers, to avoid potential confounds secondary to radiotracer retention in lungs [34]. Subjects were also excluded if they were currently (past 2 weeks) on prescription or over the counter medications.…”

Section: Methodsmentioning

confidence: 99%

Distribution and Pharmacokinetics of Methamphetamine in the Human Body: Clinical Implications

et al. 2010

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BackgroundMethamphetamine is one of the most toxic of the drugs of abuse, which may reflect its distribution and accumulation in the body. However no studies have measured methamphetamine's organ distribution in the human body.MethodsPositron Emission Tomography (PET) was used in conjunction with [11C]d-methamphetamine to measure its whole-body distribution and bioavailability as assessed by peak uptake (% Dose/cc), rate of clearance (time to reach 50% peak-clearance) and accumulation (area under the curve) in healthy participants (9 Caucasians and 10 African Americans).ResultsMethamphetamine distributed through most organs. Highest uptake (whole organ) occurred in lungs (22% Dose; weight ∼1246 g), liver (23%; weight ∼1677 g) and intermediate in brain (10%; weight ∼1600 g). Kidneys also showed high uptake (per/cc basis) (7%; weight 305 g). Methamphetamine's clearance was fastest in heart and lungs (7–16 minutes), slowest in brain, liver and stomach (>75 minutes), and intermediate in kidneys, spleen and pancreas (22–50 minutes). Lung accumulation of [11C]d-methamphetamine was 30% higher for African Americans than Caucasians (p<0.05) but did not differ in other organs.ConclusionsThe high accumulation of methamphetamine, a potent stimulant drug, in most body organs is likely to contribute to the medical complications associated with methamphetamine abuse. In particular, we speculate that methamphetamine's high pulmonary uptake could render this organ vulnerable to infections (tuberculosis) and pathology (pulmonary hypertension). Our preliminary findings of a higher lung accumulation of methamphetamine in African Americans than Caucasians merits further investigation and questions whether it could contribute to the infrequent use of methamphetamine among African Americans.

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Section: Methodsmentioning

confidence: 99%