Effects of smoking on myocardial infarction at early ages

Effects of smoking on myocardial infarction in young people

“…Finally, we entirely agree with Yetkin et al [1], whatever is the pathogenetic mechanism, that smoking has a deleterious effect on coronary arteries of young individuals and is imperative to adopt the appropriate strategy in order to eliminate this harmful habit at very early ages. …”

“…We read with interest the letter by Yetkin et al [1] in which they suggested that smoking may predispose to premature myocardial infarction (MI) by inducing coronary arterial spasm, particularly in patients with angiographically normal coronary arteries. In our study 26% of the patients with premature MI had normal coronary arteries according to angiographic findings [2].…”

“…Zieske et al [6] have reported that smoking is associated with advanced coronary atherosclerosis in young individuals. It is attractive to speculate that smoking may predispose to MI in patients with "normal" coronary arteries by inducing coronary spasm, as Yetkin et al [1] have proposed. Smoking has the potential for this since it causes endothelial dysfunction and increases coronary tone by inducing oxidative stress [7], increases platelet aggregation [8], enhances sympathetic activity [9], etc.…”

Takotsubo Cardiomyopathy as an Underlying Mediator of Myocardial Infarction with Normal Coronary Arteries

“…Smoking has previously been reported to be a major risk factor for MINCA [2,21]. It is tempting to speculate that smoking may predispose an individual with normal coronary arteries to myocardial infarction by inducing coronary spasm, as Yetkin et al [22] have proposed. Certainly, smoking has the potential to do so as it has been shown to cause endothelial dysfunction and increase coronary tone by inducing oxidative stress, increasing platelet aggregation and enhancing sympathetic activity [23,24,25].…”