Effects of smoking on clinical parameters and the gingival crevicular fluid levels of IL‐6 and TNF‐<i>α</i> in patients with chronic periodontitis

Erdemir, Ebru Olgun; Duran, Ismet; Haliloğlu, Seyfullah

doi:10.1111/j.0303-6979.2004.00454.x

Cited by 79 publications

(92 citation statements)

References 51 publications

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“…The present study has observed that smokers with chronic periodontitis showed lower GI and PBI and higher PI and CAL as compared to non-smokers with chronic periodontitis. In accordance with our study, various studies [22][23][24] have observed altered clinical parameters in smokers with chronic periodontitis compared to non-smokers.…”

Section: Discussionsupporting

confidence: 93%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein.The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers.

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Section: Discussionsupporting

confidence: 93%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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“…In the study, which performed a non-surgical treatment of chronic periodontitis by S/RP, Erdemir et al did not observe any correlation at the 6-month follow-up. 31 These findings support the view that local expressions of inflammatory mediators vary from site to site and from subject to subject. 32 In conclusion, the use of the vector ultrasonic system for non-surgical periodontal treatment presents beneficial improvements in the clinical attachment level and the probing pocket depth as well as TNF-α levels.…”

supporting

confidence: 76%

Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-α in gingival crevicular fluid of patients with chronic periodontitis

Arpağ¹,

Dağ²,

İzol³

et al. 2017

Adv Clin Exp Med

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“…These observations, seemingly paradoxical, are consistent with the biological effects of smoking. Smoking causes acute vasoconstriction and inhibits angiogenesis, proliferation, and production of inflammatory mediators in response to bacterial stimuli (42)(43)(44). However, these potent suppressive effects of smoking are reversible within a few hours of smoking cessation (43,44).…”

Section: Cancer Epidemiol Biomarkers Prev 2009;18(9) September 2009mentioning

confidence: 99%

Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma

Tezal

Sullivan

Hyland

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

284

233

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Substantial evidence supports an association between chronic infections/inflammation, and cancer. The aim of this study was to assess the effect of chronic periodontitis on head and neck squamous cell carcinoma (HNSCC). The study population consisted of new patients at the Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Cancer Institute between 1999 and 2005. Cases were patients diagnosed with primary HNSCC. Controls were all patients seen during the same time period but negative for malignancy. Patients age <21 years, edentulous, immunocompromised, and those with history of cancer were excluded. Periodontitis was measured by alveolar bone loss (ABL) from panoramic radiographs by one examiner blind to cancer status. A total of 473 patients (266 cases and 207 controls) were included in the study. Each millimeter of ABL was associated with >4-fold increased risk of HNSCC (odds ratio, 4.36; 95% confidence interval, 3.16-6.01) after adjustment for age, gender, race/ethnicity, marital status, smoking status, alcohol use, and missing teeth. The strength of the association was greatest in the oral cavity, followed by oropharynx and larynx. The association persisted in subjects who never used tobacco and alcohol. There was a significant interaction between smoking and ABL (P = 0.03). Patients with periodontitis were more likely to have poorly differentiated oral cavity SCC than those without periodontitis (32.8% versus 11.5%; P = 0.038). This study suggests that chronic periodontitis is an independent risk factor for HNSCC and smoking modifies this association. These results have implications for practical and safe strategies for prevention, diagnosis, and treatment of

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Effects of smoking on clinical parameters and the gingival crevicular fluid levels of IL‐6 and TNF‐α in patients with chronic periodontitis

Abstract: The present study demonstrated that cigarette smoking increases the amount of dental plaque over time in smokers and does not influence GCF contents of IL-6 and TNF-alpha.

Cited by 79 publications

References 51 publications

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-α in gingival crevicular fluid of patients with chronic periodontitis

Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma

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