Effects of smoking and changes in smoking habits on the decline of FEV1

The purpose of this survey was to evaluate the effects of smoking and occupational exposures on the decline in forced expiratory volume in one second (FEV1), and the presence of airflow limitation (FEV1 x100/forced vital capacity (FVC) being < 65) at follow-up. A random sample of 1,933 men aged 22-54 years in Bergen, Norway, were invited into the survey. Smoking habits and measurements of FEV1 were recorded at the initial survey in 1965-1970 (n = 1,591) and at follow-up in 1988-1990 (n = 951). Past or present self-reported occupational exposures to eleven airborne agents (dusts, gases, vapours and fumes) and measurements of FVC were recorded at follow-up only. The decline in FEV1 was associated (p < 0.001) with age, body height and smoking. Smoking cessation reduced the decline to the level of lifetime nonsmokers. Accelerated decline in FEV1 was observed in subjects exposed to sulphur dioxide gas and to metal fumes. The adjusted decline in FEV1 increased progressively in subjects exposed to increasing numbers of occupational agents (test for trend: p < 0.01). Airflow limitation was observed in 9.5% at follow-up, and increased with age and cigarette consumption. In this community follow-up survey in men, smoking and occupational exposures to sulphur dioxide gas, metal fumes and the numbers of specific agents were found to be important predictors for accelerated decline in FEV1.

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 50%

See 1 more Smart Citation

Decline in FEV1 and airflow limitation related to occupational exposures in men of an urban community

Gulsvik¹,

Skjærven²,

Nilssen³

et al. 1993

“…The analytical models comprised major risk factors for ischaemic heart disease, such as smoking habits, blood pressure, cholesterol level, BMI and diabetes mellitus, in addition to an index of ventilatory function, age and sex. Whereas smoking, diabetes and BMI can be regarded as genuine confounders because they are related to both lung function [22,23] and to the end-points of the present study, systolic blood pressure and cholesterol were included because they are wellestablished risk factors for ischaemic heart disease, although they were not significantly correlated to the lung function level in this population.…”

Section: Discussionmentioning

confidence: 99%

Ventilatory function impairment and risk of cardiovascular death and of fatal or non-fatal myocardial infarction

Lange¹,

Nyboe²,

Jensen³

et al. 1991

The relationship of ventilatory function to cardiovascular events was studied in 12,511 men and women, enrolled in 1976-1978 in a prospective population study. Until the end of 1983, 388 subjects died because of a cardiovascular disease, 133 died within 30 days of developing myocardial infarction (fatal myocardial infarction), while 238 had a non-fatal myocardial infarction. Cox proportional hazards models were employed for the analysis. In the models including tobacco smoking, cholesterol level, blood pressure, diabetes mellitus and body-mass index as covariates, forced expiratory volume in one second in percentage of predicted (FEV1% pred), forced vital capacity in percentage of predicted (FVC% pred), and the ratio between FEV1 and FVC (FEV1/FVC) were significantly related to the risk of cardiovascular death, e.g. compared with subjects with FEV1% pred or FVC% pred greater than or equal to 80 the risk of death from cardiovascular disease among subjects with FEV1% pred or FVC% pred less than 60 was approximately twice as high. There was a nonsignificant trend towards an increased risk of fatal myocardial infarction with reduction of FVC% pred, but in general the regression models did not show consistent relationship between lung function impairment and risk of myocardial infarction. In the regression models, which only included age and sex as covariates, reduced FVC% pred and FEV1% pred were significantly related to both cardiovascular mortality and to fatal myocardial infarction, but not to the non-fatal infarction, whereas the FEV1/FVC ratio was not related to fatal or to non-fatal myocardial infarction.(ABSTRACT TRUNCATED AT 250 WORDS)

“…1 exam: first examination; 2 exam: second examination; pred: predicted \lalu cs. Predicted values were obtained by estimating lhc regression of FEY 1 and FYC on age and height among IS)'mptom,llic nonsmokers from The Copenhagen City Heart Study(11 ). FEY 1 : forced expiratory volume in one ~nd: ~VC: forced vital capacity.…”

mentioning

confidence: 99%

Diabetes mellitus and ventilatory capacity: a five year follow-up study

Lange

Groth²,

Mortensen³

et al. 1990

During a five year observation period, declines of forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were investigated in 200 subjects with diabetes mellitus (DM), 126 subjects who developed DM during that period and 9,051 nondiabetic subjects. After statistical adjustment for age, sex, height, and tobacco consumption we found that the subjects who developed DM during the observation period had the steepest declines of ventilatory function. Their annual declines of FVC (and FEV1) were on average 29 ml (and 25 ml) greater than the declines observed among the nondiabetic subjects. The subjects who had DM during the whole observation period experienced a decline of ventilatory function which was not significantly greater than the decline among the nondiabetic subjects. Our results suggest that DM, at its onset, is associated with a significantly accelerated decline of ventilatory function. If DM has been present for some years, its impact on the decline of ventilatory function is small.