Effects of smokeless tobacco (Maras powder) use on carotid intima media thickness

Sucakli, Mustafa Haki; Özkan, Fuat; İnci, Mehmet Fatih; Çelık, Mustafa; Keten, Hamit Sırrı; Bozoglan, Orhan

doi:10.12659/msm.889654

Cited by 13 publications

(4 citation statements)

References 17 publications

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“…Smoking was similar between the groups. Only 1 patient from the healthy controls with ED was a smoker [ 21 ]. After exclusion, 32 patients were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome

Ünal

Aksoy²,

Aydın

et al. 2014

Med Sci Monit

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BackgroundMetabolic syndrome (MS) has become a pandemic in Turkey, as is the case globally. Increase in carotid artery intima-media thickness (CIMT) and erectile dysfunction (ED) may be evident before the clinical signs of cardiovascular disease appear. We aimed to investigate the prevalence of increased CIMT and ED as markers of atherosclerotic disease in patients with MS.Material/MethodsThirty-two patients with MS and 29 healthy controls were included. Anthropometric and biochemical parameters, along with total testosterone (TT), high sensitive C-reactive protein (hs-CRP), were recorded. Carotid artery intima-media thickness was measured. Erectile dysfunction was assessed with International Index of Erectile Function.ResultsPatients with MS had higher BMI, fasting plasma glucose, post-prandial plasma glucose, insulin, HOMA-IR, total cholesterol, triglycerides, hs-CRP, and CIMT, whereas TT levels were lower (p<0.0001). The prevalence and severity of erectile dysfunction were higher in patients with MS (p<0.0001). Erectile dysfunction scores correlated inversely with CIMT. MS patients with ED were older and had higher CIMT compared to those without ED. Increase in age and HOMA and decrease in TT increased the risk of ED. When KIMT exceeding the 95th percentile of healthy controls was accepted as a risk factor for CVD, presence of ED was the only determinant for this increase.ConclusionsErectile dysfunction was more prevalent and severe in patients with MS and correlated with subclinical endothelial dysfunction. Total testosterone deficiency was prominent among MS patients. Presence of ED points to an increased risk of cardiovascular disease when MS is present.

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“…Smoking was similar between the groups. Only 1 patient from the healthy controls with ED was a smoker [ 21 ]. After exclusion, 32 patients were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome

Ünal

Aksoy²,

Aydın

et al. 2014

Med Sci Monit

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“…10,21,22 Bu içerik Maraş otunda normal sigaranın yaklaşık 8-10 katı kadardır. 23 Erişkinlerde ölümcül doz 40-60 mg iken bu doz çocuklarda 1mg/kg'dır. 8,10 Küçük çocuklarda 1mg nikotin yutulması bulantı ve kusma gibi semptomların ortaya çıkmasına neden olur.…”

Section: Discussionunclassified

Maraş Otu İntoksikasyonu İle Kliniğimize Başvuran Çocuk Olguların Değerlendirilmesi

Güneş

Sarişik

2020

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi

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Amaç: Maraş otu (MO), tütün türlerinden olan Nicotina Rustica L. yaprakları ile meşe ve asma odunun küllerinden elde edilen, ağızda çiğnenerek kullanılan toz formunda kullanılan dumansız tütün ürünlerindendir. Bölgemizde halk arasında yaygın kullanımından dolayı çocuk vakaların erişimi kolay olmakta ve özellikle küçük yaş gruplarında ciddi intoksikasyon kliniği ile hastalar acilimize başvurmaktadırlar. Çalışmamızın amacı, acil servisimize MO' ya bağlı zehirlenme ile başvuran olguların değerlendirilmesi ve genel hatları ile bu ürünün hastalar üzerindeki etkilerinin araştırılmasıdır. Yöntem: Çalışmaya son 1 yıl içerisinde acil servisimize kazara MO yutmuş, yaşları 10 ay ile 3 yaş arasında değişen, 18 olgu dâhil edilmiştir. Hastalara ait demografik, klinik ve laboratuvar değerleri hasta dosyaları taranarak elde edilmiştir. Ek ilaç alımı olan vakalar dışlanmıştır. Veriler istatistik programına yüklenip değerlendirilmiştir. Bulgular: Çalışmaya alınan hastaların yaşları 20,5 (10-75) ay iken, bunların 10 tanesini erkek bireyler oluşturmaktaydı. Hastaların venöz kan gazı değerlerinde %33,3'ünde metabolik asidoz vardı; bu hastaların pH değerleri (7,26-7,38) iken HCO3 değerleri (16,12-20,90) mmol/L olarak değişmekteydi. Hastaların % 50'sinin laktik asit düzeyleri üst sınırlarda olup 1,9-6,10 mmol/L arasında değişmekteydi. Sonuç: MO, içerdiği yüksek nikotin oranından ve diğer maddelerden dolayı özellikle küçük yaş grubunda ciddi toksisitelere sebep olan maddelerden biri olması nedeniyle vakaların hızlıca değerlendirilip takibe alınması gerekmektedir. Anahtar kelimeler: Çocuk; dumansız tütün; Maraş otu; nikotin; zehirlenme. ABSTRACT Objective: Maras powder (MP) is a smokeless tobacco product obtained from Nicotina Rustica L., which is a type of tobacco, and the ashes of oak and grapevine, used in the form of a powder used in the mouth. Due to the widespread use among the population in our region, access to pediatric cases is easy and patients apply to our emergency department with a serious intoxication clinic especially in young age groups. The purpose of our study is to evaluate the patients who applied to our emergency department with MP-related poisoning and to investigate the general outlines and the effects of this product on patients. Materials and methods: The study included 18 cases, aged between 10 months and 3 years, who had accidentally swallowed MP to our emergency room in the past year. The demographic, clinical, and laboratory values of the patients were obtained by scanning patient files. Cases with additional drug intake are excluded. The data were uploaded to the statistical program and evaluated. Results: While the ages of the patients included in the study were 20.5 (10-75) months, 10 of them were male individuals. Metabolic acidosis was present in 33.3% of patients in venous blood gas values; while the pH values of these patients (7.26-7.38), HCO3 values (16.12-20.90) ranged from mmol / L. Lactic acid levels of 50% of the patients were at the upper limits and ranged between 1.9-6.10 mmol / L. Conclusion:...

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“…The health hazards of tobacco use are mostly focused on cigarettes, and there are studies showing the effects of smokeless tobacco on health. It has been stated that it has negative effects especially on the neurological system, immune system, cardiovascular system, oral and dental health, hematological and metabolic system (Bozoglan., 2013;Aral et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Assessment Scales Applied to Adolescents With Psychiatric Disease by Using Smokeless Tobacco by Machine Learning Methods

Altun

Arslan

2023

Preprint

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Purpose Adolescence is a fragile period in which all people live. This period can be more difficult for some people. In this difficult and fragile period, young people can suffer permanent psychological damage due to reasons such as social and family environment. One of these bad habits is smokeless tobacco. Unfortunately, the age of use may decrease worldwide due to reasons such as easy access and it can easily become addictive in adolescence, which is the sensitive period of human beings. Materials and Methods In our study, it was aimed to investigate the relationship between the use of smokeless tobacco and the use of machine learning methods in adolescents with psychiatric diagnoses. Various graded scale questions applied to adolescents were investigated with Embedded feature selection methods. Embedded methods; It can perform detailed feature selection calculations with three different calculations: Lasso, Gini and Permutation. Logistic Regression (LR) and Random Forest (RF) classification methods of selected features are used to select the most relevant features. Results Classification accuracy up to 0.98 (Lasso + LR = 0.98, Gini + RF = 0.95, Permutation + RF = 0.93) was calculated according to the selected features. Conclusion According to the results obtained from these classification methods, there is a goal of reaching the ideal by providing feedback. In our study, especially Lasso and Gini feature selections chose test questions related to smokeless tobacco use at a high rate. The permutation method also chose these test questions, but Lasso and Gini made relatively more choices.

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Effects of smokeless tobacco (Maras powder) use on carotid intima media thickness

Cited by 13 publications

References 17 publications

Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome

Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome

Maraş Otu İntoksikasyonu İle Kliniğimize Başvuran Çocuk Olguların Değerlendirilmesi

Investigation of the Assessment Scales Applied to Adolescents With Psychiatric Disease by Using Smokeless Tobacco by Machine Learning Methods

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