Effects of small for gestational age status on mortality and major morbidities in ≤750 g neonates

Poryo, Martin; Maas, Sebastian; Gortner, Ludwig; Geipel, Martina; Zemlin, Michael; Löffler, G.; Meyer, Sascha

doi:10.1016/j.earlhumdev.2020.105040

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…SGA status at birth has a negative influence on BPD, likely due to less optimal nutrition and growth in the intrauterine environment, but no previous studies have compared HOT duration in SGA versus AGA infants. 18 SGA status at birth was associated with longer durations of O 2 as well as more frequent increases in support level while weaning. SGA infants have been found to have lower pulmonary function in older childhood, 19 suggesting poorer lung development than AGA infants.…”

Section: Discussionmentioning

confidence: 90%

Duration of Home Oxygen Therapy in Preterm Infants Utilizing a Remote Patient Monitoring Program to Wean: Trajectory Patterns

White

Lee

Rhein

2023

Journal of Neonatology

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Background Up to one-third of preterm infants diagnosed with bronchopulmonary dysplasia will require home oxygen therapy (HOT) after hospital discharge. Currently, no consensus-based guidelines exist for safely managing HOT. The Recorded Home Oximetry (RHO) trial was the first to evaluate a structured weaning guideline. At the conclusion of the trial, our home institution implemented the RHO program in June 2019, utilizing the same RHO protocol as the original trial. The purpose of this project was to evaluate the duration and weaning trajectory of infants followed and identify any risk factors associated with flow rate increases or longer trajectories. Methods This is a prospective analysis of infants born <37 weeks gestation followed by the RHO program between June 2019 and June 2021. Results The study included 26 infants with a total of 407 RHO epochs. There was nearly equal distribution of males and females with a mean birth gestational age of 27.5 (±3.4 SD) weeks. The median time of successful discontinuation of HOT was 2.1 months. Infants starting on higher initial flow rates had faster weaning trajectories compared to those who started on lower flow rates ( P value <.0001). Infants born small for gestational age were about twice as likely to have longer maintenance on one flow rate compared to appropriate for gestational age infants (RR = 2.81, 95% CL 1.64-4.81, P = .0002). Conclusion The RHO program, a structured telemedicine weaning guideline, reduces the duration of HOT in preterm infants and does not cause unnecessary swings in oxygen flow rates.

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Section: Discussionmentioning

confidence: 90%

Duration of Home Oxygen Therapy in Preterm Infants Utilizing a Remote Patient Monitoring Program to Wean: Trajectory Patterns

White

Lee

Rhein

2023

Journal of Neonatology

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“…Survival without major morbidity was defined as survival in the absence of any the serious morbidities indicated in the Data collection section. 17…”

Section: Standards and Definitionsmentioning

confidence: 99%

Vitamin D Status of Preterm Newborns at Approximately 4 Weeks of Age in Shenzhen, China: A Retrospective Observational Cohort Study Conducted Across Two Centers

Guo,

Yu,

et al. 2024

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Background and Objectives:To examine the correlation between the concentration of vitamin D (VD) in venous blood at approximately 4 weeks of age (±4 weeks of age) and neonatal outcomes in preterm infants (birth weight <1500 g or gestational age <32 weeks) in two neonatal intensive care units (NICUs) located in Shenzhen, China. Methods and Study Design: Preterm infants were split into two groups based on their VD concentration at ±4 weeks of age: VD insufficiency (VDI) group (≤20 ng/mL) and VD sufficient (VDS) group (>20 ng/mL). Binary logistic regression analysis was used to examine relationships between outcomes and VDI. Results: Of 230 infants in total, 119 (51.7%) were assigned to the VDI group and 111 to the VDS group (48.3%). No correlation was found between serum VD at ±4 weeks of age and gestational age (p>0.05). The starting point of the two groups for oral VD intake did not differ significantly (p>0.05). At ±4 weeks of age, oral VD dose (P<0.05) was greater in the VDS group. Gestational diabetes mellitus was associated with VDI (OR=1.94, 95% CI 1.01-3.75, p=0.047) after controlling for this risk. Following correction for gestational age and oral VD dosage at ±4 weeks old, VDI was also linked to a significant risk of retinopathy of prematurity (OR=2.00, 95% CI 1.08-3.68, p<0.027). Conclusion: Preterm newborns (gestational age <32 weeks or birth age <1500 g) in NICUs in Shenzhen, China continue to have significantly high VDI. Higher VDI is associated with gestational diabetes mellitus and retinopathy of prematurity.

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“…1 Moreover, generating local data on mortality and major morbidities including information on SGA status may prove valuable in antenatal counselling in this highly susceptible cohort, since these data may differ significantly from other reports. 2,4…”

Section: R E a D E R S ' F O R U Mmentioning

confidence: 99%

Morbidity and mortality in extremely premature infants with a birth weight ≤500 g

et al. 2021

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Effects of small for gestational age status on mortality and major morbidities in ≤750 g neonates

Cited by 6 publications

References 48 publications

Duration of Home Oxygen Therapy in Preterm Infants Utilizing a Remote Patient Monitoring Program to Wean: Trajectory Patterns

Duration of Home Oxygen Therapy in Preterm Infants Utilizing a Remote Patient Monitoring Program to Wean: Trajectory Patterns

Vitamin D Status of Preterm Newborns at Approximately 4 Weeks of Age in Shenzhen, China: A Retrospective Observational Cohort Study Conducted Across Two Centers

Morbidity and mortality in extremely premature infants with a birth weight ≤500 g

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Effects of small for gestational age status on mortality and major morbidities in ≤750 g neonates

Cited by 6 publications

References 48 publications

Duration of Home Oxygen Therapy in Preterm Infants Utilizing a Remote Patient Monitoring Program to Wean: Trajectory Patterns

Duration of Home Oxygen Therapy in Preterm Infants Utilizing a Remote Patient Monitoring Program to Wean: Trajectory Patterns

Vitamin D Status of Preterm Newborns at Approximately 4 Weeks of Age in Shenzhen, China: A Retrospective Observational Cohort Study Conducted Across Two Centers

Morbidity and mortality in extremely premature infants with a birth weight ≤500 g

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Effects of small for gestational age status on mortality and major morbidities in ≤750 g neonates