Effects of sleeve gastrectomy on the composition and diurnal oscillation of gut microbiota related to the metabolic improvements

Shao, Yikai; Shen, Qiwei; Hua, Rong; Evers, Simon S.; He, Kai; Yao, Qiyuan

doi:10.1016/j.soard.2018.02.024

Cited by 17 publications

(19 citation statements)

References 28 publications

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“…Changes in GI microbiota was the primary outcome for 24 studies in Group 1 [ 37 , 38 , 39 , 40 , 41 , 42 , 44 , 45 , 47 , 48 , 49 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 75 , 76 , 77 , 78 , 79 , 94 ] and 12 studies in Group 2 [ 61 , 62 , 64 , 65 , 68 , 82 , 85 , 86 , 88 , 90 , 92 , 95 ]. For the remaining studies, primary outcomes surrounding clinical, anthropometric and metabolic parameters were reported (Group 1: n = 5 [ 43 , 46 , 50 , 58 , 74 ]; Group 2: n = 13 [ 60 , 63 , 66 , 67 , 69 , 80 , 81 , 83 , …”

Section: Resultsmentioning

confidence: 99%

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

et al. 2020

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The gastrointestinal (GI) microbiota plays an important role in health and disease, including brain function and behavior. Bariatric surgery (BS) has been reported to result in various changes in the GI microbiota, therefore demanding the investigation of the impact of GI microbiota on treatment success. The goal of this systematic review was to assess the effects of BS on the microbiota composition in humans and other vertebrates, whether probiotics influence postoperative health, and whether microbiota and psychological and behavioral factors interact. A search was conducted using PubMed and Web of Science to find relevant studies with respect to the GI microbiota and probiotics after BS, and later screened for psychological and behavioral parameters. Studies were classified into groups and subgroups to provide a clear overview of the outcomes. Microbiota changes were further assessed for whether they were specific to BS in humans through the comparison to sham operated controls in other vertebrate studies. Changes in alpha diversity appear not to be specific, whereas dissimilarity in overall microbial community structure, and increases in the abundance of the phylum Proteobacteria and Akkermansia spp. within the phylum Verrucomicrobia after surgery were observed in both human and other vertebrates studies and may be specific to BS in humans. Human probiotic studies differed regarding probiotic strains and dosages, however it appeared that probiotic interventions were not superior to a placebo for quality of life scores or weight loss after BS. The relationship between GI microbiota and psychological diseases in this context is unclear due to insufficient available data.

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Section: Resultsmentioning

confidence: 99%

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

et al. 2020

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“…In RYGB, at the phylum level, Proteobacteria has been reported to be increased at the expense of Firmicutes (Zhang et al, 2009; Tremaroli et al, 2015), while Bacteroidetes has been found inconsistently changed, either increased (Furet et al, 2010) or decreased (Li et al, 2011; Graessler et al, 2013). In VSG, both animal and human studies showed increased Bacteroidetes and decreased Firmicutes, and rebuilt of the gut microbiota diversity (Jahansouz et al, 2017; Murphy et al, 2017; Shao et al, 2018). At the species level, the outcomes have been inconsistently reported across different studies, further increasing the difficulty of gut microbiota research.…”

Section: Microbiota and Bile Acidsmentioning

confidence: 99%

Role of Bile Acids in Bariatric Surgery

et al. 2019

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Bariatric surgery has been proved to be effective and sustainable in the long-term weight-loss and remission of metabolic disorders. However, the underlying mechanisms are still far from fully elucidated. After bariatric surgery, the gastrointestinal tract is manipulated, either anatomically or functionally, leading to changed bile acid metabolism. Accumulating evidence has shown that bile acids play a role in metabolic regulation as signaling molecules other than digestive juice. And most of the metabolism-beneficial effects are mediated through nuclear receptor FXR and membrane receptor TGR5, as well as reciprocal influence on gut microbiota. Bile diversion procedure is also performed on animals to recapitulate the benefits of bariatric surgery. It appears that bile acid alteration is an important component of bariatric surgery, and represents a promising target for the management of metabolic disorders.

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“…As described [46][47][48][49][50], sham surgeries were performed by externalizing the bowel and applying pressure with forceps at the SGIT anastomosis sites, and along the greater curvature of the stomach. The sham surgery took approximately 45 minutes per mouse.…”

Section: Sham Surgery Techniquementioning

confidence: 99%

Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition

et al. 2018

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Background: Sleeve gastrectomy with ileal transposition has been shown to be superior to sleeve gastrectomy alone for promoting weight loss in rat and porcine models. The absence of a mouse model for this procedure has impeded efforts to understand the molecular physiology underlying its efficacy. This study demonstrates the long term survivability of sleeve gastrectomy with ileal transposition in mice. Materials and Methods: In this study of technical feasibility, a sleeve gastrectomy with ileal transposition (SGIT), sleeve gastrectomy (SG), or sham surgery (SH) was performed on 7 to 8week old C57BI/6J mice (n=8 for each). To evaluate long term survivability, mice were placed on an obesogenic diet and weighed weekly for 10 weeks. The intestinal identify of the transposed segment was assessed with gene expression analysis of duodenal-, jejunal-, and ileal-specific hormones using quantitative polymerase chain reaction. Results: Overall, SGIT better prevented weight gain than the SG or sham procedures (10-week postoperative weight: SH: 45.3±1.0 grams, SG: 41.25±1.6 grams, SGIT: 35.4±0.8 grams). Gene expression pattern analysis of three markers of intestinal identity (gastrin, cholecystokinin, and peptide YY) suggest that the ileal identity of the transposed segment is maintained 10-weeks after transposition. Conclusions: We demonstrate for the first time a reproducible mouse model of sleeve gastrectomy with ileal transposition. Future studies utilizing this model will expand our understanding of the molecular pathways through which the hindgut regulates satiety.

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Effects of sleeve gastrectomy on the composition and diurnal oscillation of gut microbiota related to the metabolic improvements

Cited by 17 publications

References 28 publications

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

Role of Bile Acids in Bariatric Surgery

Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition

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