Effects of sleep state on ventilatory acclimatization to hypoxia in humans

Berssenbrugge, A.; Dempsey, Jerome A.; Skatrud, James B.

doi:10.1152/jappl.1984.57.4.1089

Cited by 32 publications

(19 citation statements)

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“…As previously discussed, fragmenting REM sleep arousals following events of irregular breathing, unscorable according to clinical criteria (ASDA), may be accountable. This contradicts previous observations at high altitudes where breathing irregularity disappeared with restitution of regular breathing during REM sleep (Berssenbrugge et al 1984;Normand et al 1990). This contradiction is supported by our observation that seven of the ten athletes with RDI<10 had more RDI during REM than NREM sleep.…”

Section: Discussioncontrasting

confidence: 93%

Sleep disturbance at simulated altitude indicated by stratified respiratory disturbance index but not hypoxic ventilatory response

Kinsman¹,

Townsend²,

Gore³

et al. 2005

Eur J Appl Physiol

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At high altitudes, the clinically defined respiratory disturbance index (RDI) and high hypoxic ventilatory response (HVR) have been associated with diminished sleep quality. Increased RDI has also been observed in some athletes sleeping at simulated moderate altitude. In this study, we investigated relationships between the HVR of 14 trained male endurance cyclists with variable RDI and sleep quality responses to simulated moderate altitude. Blood oxygen saturation (SpO2%), heart rate, RDI, arousal rate, awakenings, sleep efficiency, rapid eye movement (REM) sleep, non-REM sleep stages 1, 2 and slow wave sleep as percentages of total sleep time (%TST) were measured for two nights at normoxia of 600 m and one night at a simulated altitude of 2,650 m. HVR and RDI were not significantly correlated with sleep stage, arousal rate or awakening response to nocturnal simulated altitude. SpO2 was inversely correlated with total RDI (r = -0.69, P = 0.004) at simulated altitude and with the change in arousal rate from normoxia (r = -0.65, P = 0.02). REM sleep response to simulated altitude correlated with the change, relative to normoxia, in arousal (r = -0.63, P = 0.04) and heart rate (r = -0.61, P = 0.04). When stratified, those athletes at altitude with RDI >20 h(-1) (n = 4) and those with <10 h(-1) (n = 10) exhibited no difference in HVR but the former had larger falls in SpO2 (P = 0.05) and more arousals (P = 0.03). Neither RDI (without stratification) nor HVR were sufficiently sensitive to explain any deterioration in REM sleep or arousal increase. However, the stratified RDI provides a basis for determining potential sleep disturbance in athletes at simulated moderate altitude.

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Section: Discussioncontrasting

confidence: 93%

Sleep disturbance at simulated altitude indicated by stratified respiratory disturbance index but not hypoxic ventilatory response

Kinsman¹,

Townsend²,

Gore³

et al. 2005

Eur J Appl Physiol

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“…Both hypoxia and hypocapnia have been suggested as the stimuli that trigger and sustain periodic breathing at altitude [29,30]. In sea-level natives ascending to altitude, SDB is related to an increased HVR [13,14] but in long-term residents at altitude the HVR is blunted [3,31], therefore it is likely that other mechanisms may determine the nocturnal respiratory instability in these subjects.…”

Section: Discussionmentioning

confidence: 99%

Sleep-related hypoxaemia and excessive erythrocytosis in Andean high-altitude natives

Spicuzza¹,

Casiraghi²,

Gamboa³

et al. 2004

European Respiratory Journal

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To determine whether nocturnal hypoxaemia contributes to the excessive erythrocytosis (EE) in Andean natives, standard polysomnographies were performed in 10 patients with EE and in 10 controls (mean haematocrit 76.6 ¡ 1.3% and 54.4 ¡ 0.8%, respectively) living at an altitude of 4,380 m. In addition, the effect of O 2 administration for 1 h prior to sleep, and the relationship between the hypoxic/ hypercapnic ventilatory response and the apnoea/hypopnoea index (AHI) during sleep were studied.Awake arterial oxygen saturation (Sa,O 2 ) was significantly lower in patients with EE than in controls (83.7¡0.3% versus 85.6¡0.4%). In both groups, the mean Sa,O 2 significantly decreased during sleep (to 80.0¡0.8% in EE and to 82.8¡0.5% in controls). The mean Sa,O 2 values remained significantly lower in patients with EE than in controls at all times of the night, and patients with EE spent significantly more time than the controls with an Sa,O 2 of v80%. There were no differences between the two groups in the number and duration of the apnoeas/hypopnoeas. None of these variables were affected by O 2 administration. In both groups the AHI positively correlated with the hypercapnic ventilatory response.Andean natives undergo minor respiratory disorders during sleep. The reduction in oxygen saturation found in subjects with excessive erythrocytosis was small, yet consistent and potentially important, as it remained below the threshold known for the increase in erythropoietin stimulation. This may be an important factor promoting erythropoiesis, but its relevance needs to be further explored.

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“…Studies have demonstrated that hypoxia reduces delta and REM sleep and prolongs stages 1 and 2 of NREM sleep (Berssenbrugge et al 1984). However, it is not possible to determine whether the effects of obstructive sleep apnea in humans are caused by hypoxia per se or whether they are due to the frequency of arousals induced by breathing alterations during sleep or both (Berssenbrugge et al 1983).…”

Section: Estrous Cyclementioning

confidence: 99%

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

Tufik

Andersen

Bittencourt

et al. 2009

An. Acad. Bras. Ciênc.

139

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Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.

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Effects of sleep state on ventilatory acclimatization to hypoxia in humans

Cited by 32 publications

References 0 publications

Sleep disturbance at simulated altitude indicated by stratified respiratory disturbance index but not hypoxic ventilatory response

Sleep disturbance at simulated altitude indicated by stratified respiratory disturbance index but not hypoxic ventilatory response

Sleep-related hypoxaemia and excessive erythrocytosis in Andean high-altitude natives

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

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