Effects of sleep apnea hypopnea syndromes on cardiovascular events: a systematic review and meta-analysis

Xie, Liang; Zhen, Penghao; Yu, Fuchao; Yu, Xiaofang; Qian, Hai; Yang, Fang; Tong, Jiayi

doi:10.1007/s11325-021-02294-3

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Some studies have reported lower troponin levels in OSA patients presenting with AMI, suggesting a cardioprotective effect [31]. Additionally, meta-analyses have failed to identify significant differences in troponin, CK, and CK-MB levels between cardiovascular disease patients with and without OSA [32]. Our results contribute to this ongoing controversy since CRP levels were higher in AMI patients without OSA compared to those with OSA.…”

Section: Discussionmentioning

confidence: 57%

Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis

Vega-Jasso,

Amezcua-Guerra,

González-Pacheco

et al. 2023

IJMS

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An association has been suggested between acute myocardial infarction (AMI) and obstructive sleep apnea (OSA). Considering the role of adipose-tissue-derived inflammatory mediators (adipokines) and the shared risk factor of obesity in OSA and AMI, this study aimed to investigate the involvement of adipokines in AMI patients with and without OSA. Serum levels of adipokines and inflammatory mediators were quantified, and home respiratory polygraphy was conducted. A total of 30 AMI patients and 25 controls were included. Patients with AMI exhibited elevated levels of resistin (7.4 vs. 3.7 ng/mL), interleukin-6 (8.8 vs. 1.3 pg/mL), and endothelin-1 (3.31 vs. 1.8 pg/mL). Remarkably, AMI patients with concomitant OSA exhibited higher levels of resistin (7.1 vs. 3.7 ng/mL), interleukin-6 (8.9 vs. 1.3 pg/mL), endothelin-1 (3.2 vs. 1.8 pg/mL), creatin kinase (1430 vs. 377 U/L), creatine kinase-MB (64.6 vs. 9.7 ng/mL), and troponin T (2298 vs. 356 pg/mL) than their non-OSA counterparts. Leptin showed a correlation with OSA severity markers. OSA was associated with greater cardiac damage in AMI patients. Our findings underscore that adipokines alone are not sufficient to discriminate the risk of AMI in the presence of OSA. Further research is necessary to determine the potential mechanisms contributing to exacerbated cardiac damage in patients with both conditions.

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Section: Discussionmentioning

confidence: 57%

Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis

Vega-Jasso,

Amezcua-Guerra,

González-Pacheco

et al. 2023

IJMS

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The hormesis principle of neuroplasticity and neuroprotection

Mattson,

Leak

2024

Cell Metabolism

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New Modifiable Risk Factors Influencing Coronary Artery Disease Severity

Florek,

Kübler,

Górka

et al. 2024

IJMS

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Cardiovascular diseases (CVDs) remain the leading cause of death worldwide with coronary artery disease (CAD) being the first culprit in this group. In terms of CAD, not only its presence but also its severity plays a role in the patient’s treatment and prognosis. CAD complexity can be assessed with the indicator named the SYNTAX score (SS). A higher SS is associated with major adverse cardiovascular event (MACE) occurrence in short- and long-term observations. Hence, the risk factors affecting CAD severity based on SS results may help lower the risk among patients with already developed CAD to reduce their impact on coronary atherosclerosis progression. The well-established risk factors of CAD are consistent with those associated with the coronary plaque burden. However, recently, it was shown that new indicators exist, which we present in this paper, that significantly contribute to CAD complexity such as inflammatory parameters, C-reactive protein (CRP), ratios based on blood smear results, and uric acid. Moreover, microbiota alteration, vitamin D deficiency, and obstructive sleep apnea (OSA) also predicted CAD severity. However, sometimes, certain indicators were revealed as significant only in terms of chronic coronary syndromes (CCSs) or specific acute coronary syndromes (ACSs). Importantly, there is a need to apply the interdisciplinary and translational approach to the novel CAD severity risk assessment to maximize the impact of secondary prevention among patients at risk of coronary atherosclerosis progression.

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Effects of sleep apnea hypopnea syndromes on cardiovascular events: a systematic review and meta-analysis

Cited by 3 publications

References 52 publications

Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis

Adipokines and Inflammatory Markers in Acute Myocardial Infarction Patients with and without Obstructive Sleep Apnea: A Comparative Analysis

The hormesis principle of neuroplasticity and neuroprotection

New Modifiable Risk Factors Influencing Coronary Artery Disease Severity

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