Effects of sirtuin 1 activation on nicotine and lipopolysaccharide‐induced cytotoxicity and inflammatory cytokine production in human gingival fibroblasts

Abstract

This study is the first to show that the anti-inflammatory and cytoprotective effects of SIRT1 activation in HGFs occur through the PKC, PI3K, MAPK and NF-κB pathways.

Cytotoxicity and apoptosis induction by e-cigarette fluids in human gingival fibroblasts

“…This may be due to an impairment in the defense surveillance of macrophages and neutrophils [6]. One of the major effects of nicotine is the generation of intracellular oxidative stress [7][8][9], leading to cell death via apoptosis through numerous molecules including members of the Bax/bcl-2 family [9,10]. There is morphological evidence of increased oxidative stress-induced apoptosis in HGFs with transient activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinases (ERK) and concomitant activation of p38 evidenced by caspase-3 activation, and cleavage of poly ADP ribose polymerase (PARP).…”

Studies on Periodontal Disease

“…In human gingival fi broblasts, resveratrol decreased LPS and nicotine-induced cytotoxicity, ROS and PGE2 production, and expression of cyclooxygenase-2 [ 232 ]. Resveratrol inhibited nicotine and LPS-mediated protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), p38, extracellular signal-regulated kinase, JNK, MAPK, and NF-κB activation.…”

“…Adipose tissue , 168,198,199,245,255 Aerobic ,7,78,107,110,113,114,116, 3, 4, 6, 8, 10, 11, 33-44, 63, 64, 80, 81, 107, 108, 134, 137, 147, 168-169, 185, 186, 190, 197, 198, 200-202, 236, 238, 252, 254, 257, 261, 264-266, 280 6, 8, 9, 20, 24, 26, 27, 134, 135, 176-178, 183-192, 218, 228, 233, 246, [20][21][22][23][24][25][26][27][28]36,37,53,56,86,108,115,134,137,147,172,176,178,197,201,[211][212][213]215,220,228,229,232,236,240,241,244,245,252,261,…”

“…See Total antioxidant capacity (TAC) Tail , 79, 236, 243 Tangeretin (5,6,7,8,4'-pentamethoxy fl avone) , 289 Tannerella forsythia , 160, 228 T cell ,23, 58, 135, 176, 215, 217,232,241,245, 286 T-cell immunodefi ciency together ,217 Tea , 9, 41, 281, 282, 285, 286, 289 Teeth , 7,[35][36][37][38] 43, 53, 54, 57, 86, 133, 147, 160, 172, 211, 212, 215,227,228,255,256,258,259,263, 264 Teeth ligature , 259 Teeth loss , 228 Telomere length , 138, 140-142 Telomeres , 138, 140-142 Template strand , 100 Tempol , 9, 10, 42, 43, 290 Tempromadibular disease , 217 Tension , 99, 101, 102 Terminalia chebula , 290 Terminal oxidase , 117, 122 Tert-butyl hydroperoxide , 136 Tethering , 184 Tetracycline , 120 TH2 , 23, 241, 262 Th17 , 241, 262 The guardian of the genome , 79, 90 T-helper , 262 T helper 1 , 241 Theoretical level , 246 Therapeutic actions , 134 Thermal insulation , 257 Thermophilus , 111 T. catalases , 111 Thermus thermophilus , 111 Thiamin , 259 Thiobarbituric acid , 39, 139 Thiobarbituric acid reactive substances , 39, 139 Thiol peroxidase , 112-114, 121 Thioredoxin , 109, 113, 114, 134, 135 Thioredoxin family , 135 Thioredoxin-interacting protein , 134 Thioredoxin reductase , 113, 134 Thioredoxins , 134 Thr , 118, 119 Thr407 , 118, 119 Threonine , 253 Thrombosis , 283 Thymine , 213 Thymoquinone , 42, 290 Thymus-dependent system , 215 Thyroid disorders , 212 55, 85-87, 134 infl ammation , 6, 87, 168 injury , 42, 158, 168 TLR2 , 40, 162 Tlr4 , 162 T lymphocytes , 134, 184, 214, 232 TNFR1 , 243 Tocopherol , 261, 282 Tocotrienols , 261 Toll-like receptor , 18, 20, 40, 59, 240 Tongue , 212, 215, 267 Tooth , 7, 33, 35, 54-58, 60, 66, 115, 147, 171, Total antioxidant capacities , 40 Total antioxidant capacity (TAC) , 136-138, 148, 149, 152, 173, 281 Toxic proteins , 176 Toxins , 120, 232, 243, 245, 246 Trauma , 18, 168, 201, 243 Treatment-placebo trial , 261 Treatment studies , 141, 185 Treponema denticola , 160, 228 Trial duration , 191 Tricarboxylic acid cycle , 237 Trifunctional enzyme complex , 213 Trigger , 22, 78, 79, 82, 85-91, 97, 103, 109, 141, 158, 167, 177, 178, 230, 243, 246, 256 Triglyceride-rich lipoproteins , 174, 198 Triglycerides , 174, 235 Triglyceride synthesis , 240 Triphala , 290 Triple FLAG tag , 161 Triplicate experiments , 216-218 Trisomic genes , 212, 220 Trisomy , 212 Trp , 118 Trx80 , 134 Trypanosome , 122 Trypanosomiasis , 122 Tryptophan , 118, 253 Tumor necrosis factor alpha , 168, 185, 204 Turnover , 19, 114, 198, 244, 253 Type 2 diabetes , 40, 150, 151, 171, 175, 177 Tyr , 118 Tyrosine kinases , 288 U Ubiquinol-1 , 116, 118, 119 Ubiquinone-1 , 122 Ulceration , 62, 184 Ulcerative colitis , 22 Ultrasound , 18 Ultraviolet light , 18, 102, 108 Uncitrullinated enolase , 178 Unconventionally secreted cytokines , 241 Unsaturated fatty acids , 235, 236 Unsaturation , 236 Urate , 7 Urea cycle , 237 Uric acid , 137, 242, 280 Urine , 139, 212, 219, 258, 283 Vessel lumen , 184, 190 Vimentin , 178 Viral infection , 243 Virulence , 37, 53, 55, 60, 61, 67, 120-123, 134, 135, 160, 162, 172, 200, 242 Virulence factor , 53, 55, 60, 61, 67, 120, 121, 134, 135, 160, 162, 172 Vitamin , 41, 189, 235, 252, 257-263 Vitamin A , 137, 261 Vitamin B1 , 259 Vitamin B2 , 259 Vitamin B6 , 259 Vitamin B12 , 259, 265 Vitamin-B complex ,…”

Effects of nicotine on corneal wound healing following acute alkali burn

“…It is well documented that nicotine is involved in several intracellular signaling pathways, such as the janus-activated kinase/STAT, PKC, PI3K/Akt, and Ras/Raf/MEK/ERK pathways [30, 31]. One recent study indicated that nicotine could induce hepatic stellate cell proliferation mediated by PI3K and PKC and contribute to hepatic fibrosis in chronic liver disease [7].…”