Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines

Yu, Li; Chen, Xin; Cui, Yong; Wang, Qun; Chen, Suiyun; Wang, Xiaofang

doi:10.3892/ol.2019.10063

Cited by 15 publications

(16 citation statements)

References 46 publications

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“…We obtained 16 genes in total: TAGLN2, IGFBP2, EMP3, TIMP1, GPX8, RAB34, ADAM12, NSUN7, SH2D4A, CHI3L1, PLAT, VAV3, FBXO17, SIRT1, FAM20C, and RARRES2. We found that some of these genes can be supported by literature evidence [18,25,1,16,21,22,20,17,9,10]. For example, TAGLN2 has been reported to be a biomarker of gliomas and promote tumorigenesis [11].…”

Section: Genes For Early Detectionsupporting

confidence: 71%

SurvODE: Extrapolating Gene Expression Distribution for Early Cancer Identification

Chen

Wang

2021

Preprint

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With the increasingly available large-scale cancer genomics datasets, machine learning approaches have played an important role in revealing novel insights into cancer development. Existing methods have shown encouraging performance in identifying genes that are predictive for cancer survival, but are still limited in modeling the distribution over genes. Here, we proposed a novel method that can simulate the gene expression distribution at any given time point, including those that are out of the range of the observed time points. In order to model the irregular time series where each patient is one observation, we integrated a neural ordinary differential equation (neural ODE) with cox regression into our framework. We evaluated our method on eight cancer types on TCGA and observed a substantial improvement over existing approaches. Our visualization results and further analysis indicate how our method can be used to simulate expression at the early cancer stage, offering the possibility for early cancer identification.

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Section: Genes For Early Detectionsupporting

confidence: 71%

SurvODE: Extrapolating Gene Expression Distribution for Early Cancer Identification

Chen

Wang

2021

Preprint

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“…Multiple studies have shown the process of SIRT1 being targeted by miR-22, miR-34a, miR-200a, miR-138, miR-30e-5P, miR-204, miR-212, and miR-449a to suppress cell proliferation in tumor progression [30]. [28] Rb, p107 and p130 Glioma [32] EMT pathway BC [33] AKT [38] MYCN HCC [39] APC, CDC20 PAC [38] MYC BC [39] APC, CDC20…”

Section: Sirtuins and Viability In Cancersmentioning

confidence: 99%

The Roles of Sirtuin Family Proteins in Cancer Progression

Zhao

Hou

et al. 2019

Cancers

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Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype, mainly participating in cancer cell viability, apoptosis, metastasis, and tumorigenesis. Although sirtuin family members have a high degree of homology, they may play different roles in various kinds of cancer. This review highlights their fundamental roles in tumorigenesis and cancer development and provides a critical discussion of their dual roles in cancer, namely, as tumor promoters or tumor suppressors.

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“…Studies on the role of SIRT1 as a tumor suppressor or oncogene are controversial and may depend on the tumor type [15]. Under massive levels of DNA damage and loss of tumor suppressors or checkpoints, SIRT1 overexpression promotes cancer formation [15][16][17]. In oral cancer, SIRT1 expression correlated with tumor repression and its downregulation at transcriptional level is linked to malignant transformation, invasion and metastasis [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27

Mele

Martino

Salzano

et al. 2020

Cancers

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Betaines are food components widely distributed in plants, animals, microorganisms, and dietary sources. Among betaines, δ-valerobetaine (N,N,N-trimethyl-5-aminovaleric acid, δVB) shares a metabolic pathway common to γ-butyrobetaine (γBB). The biological properties of δVB are particularly attractive, as it possesses antioxidant, anti-inflammatory and anticancer activities. Here, we investigated the possible synergism between δVB and the structurally related γBB, to date unexplored, by testing the in vitro anticancer activity in head and neck squamous cell carcinoma cell lines, FaDu, UM-SCC-17A and Cal 27. Among cell lines tested, results indicated that betaines showed the highest effect in reducing Cal 27 cell proliferation up to 72 h (p < 0.01). This effect was enhanced when betaines were administered in combination (δVB plus γBB) (p < 0.001). Inhibition of cell growth by δVB plus γBB involved reactive oxygen species (ROS) accumulation, upregulation of sirtuin 1 (SIRT1), and apoptosis (p < 0.001). SIRT1 gene silencing by small interfering RNA decreased the apoptotic effect of δVB plus γBB by modulating downstream procaspase-3 and cyclin B1 (p < 0.05). These findings might have important implications for novel prevention strategies for tongue squamous cell carcinoma by targeting SIRT1 with naturally occurring betaines.

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Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines

Cited by 15 publications

References 46 publications

SurvODE: Extrapolating Gene Expression Distribution for Early Cancer Identification

SurvODE: Extrapolating Gene Expression Distribution for Early Cancer Identification

The Roles of Sirtuin Family Proteins in Cancer Progression

Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27

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